{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T14:43:45Z","timestamp":1776869025634,"version":"3.51.2"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,8,11]],"date-time":"2011-08-11T00:00:00Z","timestamp":1313020800000},"content-version":"vor","delay-in-days":222,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>Nerve crush injury is a well\u2010established axonotmetic model in experimental regeneration studies to investigate the impact of various pharmacological treatments. <jats:italic>Hericium erinaceus<\/jats:italic> is a temperate mushroom but is now being cultivated in tropical Malaysia. In this study, we investigated the activity of aqueous extract of <jats:italic>H. erinaceus<\/jats:italic> fresh fruiting bodies in promoting functional recovery following an axonotmetic peroneal nerve injury in adult female Sprague\u2010Dawley rats by daily oral administration. The aim was to investigate the possible use of this mushroom in the treatment of injured nerve. Functional recovery was assessed in behavioral experiment by walking track analysis. Peroneal functional index (PFI) was determined before surgery and after surgery as rats showed signs of recovery. Histological examinations were performed on peroneal nerve by immunofluorescence staining and neuromuscular junction by combined silver\u2010cholinesterase stain. Analysis of PFI indicated that return of hind limb function occurred earlier in rats of aqueous extract or mecobalamin (positive control) group compared to negative control group. Regeneration of axons and reinnervation of motor endplates in extensor digitorum longus muscle in rats of aqueous extract or mecobalamin group developed better than in negative control group. These data suggest that daily oral administration of aqueous extract of <jats:italic>H. erinaceus<\/jats:italic> fresh fruiting bodies could promote the regeneration of injured rat peroneal nerve in the early stage of recovery.<\/jats:p>","DOI":"10.1093\/ecam\/neq062","type":"journal-article","created":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T01:48:02Z","timestamp":1274924882000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom <i>Hericium erinaceus<\/i> (Bull.: Fr) Pers. (Aphyllophoromycetideae)"],"prefix":"10.1155","volume":"2011","author":[{"given":"Kah-Hui","family":"Wong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murali","family":"Naidu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"David","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmood Ameen","family":"Abdulla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noorlidah","family":"Abdullah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umah Rani","family":"Kuppusamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikineswary","family":"Sabaratnam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8,11]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmod.2004.09.008"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123\u2010200207000\u201000031"},{"key":"e_1_2_7_3_2","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/0363-5023(94)90011-6","article-title":"Nerve transfer to biceps muscle using a part of ulnar nerve for C5-C6 avulsion of the brachial plexus: anatomical study and report of four cases","volume":"19","author":"Oberlin C.","year":"1994","journal-title":"Journal of Hand Surgery"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20108993(01)02395\u20102"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.5.1244"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/neh107"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1615\/IntJMedMushrooms.v1.i2.10"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1358\/dof.2008.033.02.1173290"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023963509393"},{"key":"e_1_2_7_10_2","unstructured":"MoldavanM. 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