{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T02:33:46Z","timestamp":1768876426231,"version":"3.49.0"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,3,13]],"date-time":"2011-03-13T00:00:00Z","timestamp":1299974400000},"content-version":"vor","delay-in-days":71,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Institutional Research Fund of Boseinstitute"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>Present study investigates the beneficial role of the aqueous extract of the fruits of <jats:italic>Pithecellobium dulce<\/jats:italic> (AEPD) against carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)\u2010induced hepatic injury using a murine model. AEPD has been found to possess free radical (DPPH, hydroxyl and superoxide) scavenging activity in cell\u2010free system. CCl<jats:sub>4<\/jats:sub> exposure increased the activities of various serum maker enzymes and intracellular reactive oxygen species (ROS) production. In line with these findings, we also observed that CCl<jats:sub>4<\/jats:sub> intoxication increased the lipid peroxidation and protein carbonylation accompanied by decreased intracellular antioxidant defense, activity of cytochrome P450 and CYP2E1 expression. DNA fragmentation and flow cytometric analyses revealed that CCl<jats:sub>4<\/jats:sub> exposure caused hepatic cell death mainly via the necrotic pathway. Treatment with AEPD both pre\u2010 and post\u2010toxin exposure protected the organ from CCl<jats:sub>4<\/jats:sub>\u2010induced hepatic damage. Histological findings also support our results. A well\u2010known antioxidant vitamin C was included in this study to compare the antioxidant potency of AEPD. Combining all, results suggest that AEPD protects murine liver against CCl<jats:sub>4<\/jats:sub>\u2010induced oxidative impairments probably via its antioxidative property.<\/jats:p>","DOI":"10.1093\/ecam\/neq065","type":"journal-article","created":{"date-parts":[[2010,6,22]],"date-time":"2010-06-22T00:54:57Z","timestamp":1277168097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Phytomedicinal Role of <i>Pithecellobium dulce<\/i> against CCl<sub>4<\/sub>\u2010mediated Hepatic Oxidative Impairments  and Necrotic Cell Death"],"prefix":"10.1155","volume":"2011","author":[{"given":"Prasenjit","family":"Manna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudip","family":"Bhattacharyya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joydeep","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyotirmoy","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parames C.","family":"Sil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,13]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1080\/713611034"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408690490911701"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coem.2004.03.008"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2005.pto_97103.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/S0021-9258(17)43327-8","article-title":"Oxygen- and carbon-centered free radical formation during carbon tetrachloride metabolism. 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