{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:15:06Z","timestamp":1791238506525,"version":"4.1.0"},"reference-count":157,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"European Society for Paediatric Gastroenterology Hepatology and Nutrition"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Inflammatory bowel disease [IBD] is often one of the most devastating and debilitating chronic gastrointestinal disorders in children and adolescents. The main objectives here were to systematically review the incidence and prevalence of paediatric IBD across all 51 European states.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We undertook a systematic review and meta-analysis based on PubMed, CINAHL, the Cochrane Library, searches of reference lists, grey literature and websites, covering the period from 1970 to 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Incidence rates for both paediatric Crohn\u2019s disease [CD] and ulcerative colitis [UC] were higher in northern Europe than in other European regions. There have been large increases in the incidence of both paediatric CD and UC over the last 50 years, which appear widespread across Europe. The largest increases for CD have been reported from Sweden, Wales, England, the Czech Republic, Denmark and Hungary, and for UC from the Czech Republic, Ireland, Sweden and Hungary. Incidence rates for paediatric CD have increased up to 9 or 10 per 100 000 population in parts of Europe, including Scandinavia, while rates for paediatric UC are often slightly lower than for CD. Prevalence reported for CD ranged from 8.2 per 100 000 to approximately 60 and, for UC, from 8.3 to approximately 30.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of paediatric IBD continues to increase throughout Europe. There is stronger evidence of a north\u2013south than an east\u2013west gradient in incidence across Europe. Further prospective studies are needed, preferably multinational and based on IBD registries, using standardized definitions, methodology and timescales.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjaa037","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T20:16:00Z","timestamp":1582834560000},"page":"1119-1148","source":"Crossref","is-referenced-by-count":104,"title":["A Systematic Review and Meta-analysis of Paediatric Inflammatory Bowel Disease Incidence and Prevalence Across Europe"],"prefix":"10.1093","volume":"14","author":[{"given":"S E","family":"Roberts","sequence":"first","affiliation":[{"name":"Medical School, Swansea University, Swansea, Wales, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Thorne","sequence":"additional","affiliation":[{"name":"Medical School, Swansea University, Swansea, Wales, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Thapar","sequence":"additional","affiliation":[{"name":"Neurogastroenterology and Motility Unit, Department of Gastroenterology, Great Ormond Street Hospital, London, UK"},{"name":"Stem Cells and Regenerative Medicine, UCL Great Ormond Street Institute of Child Health, London, UK"},{"name":"Prince Abdullah Ben Khalid Celiac Research Chair, College of Medicine, King Saud University, Riyadh, Saudi Arabia"},{"name":"Gastroenterology, Hepatology and Liver Transplant, Queensland Children\u2019s Hospital, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Broekaert","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University Children\u2019s Hospital, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Benninga","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, University of Amsterdam, Emma Children\u2019s Hospital, Department of Pediatric Gastroenterology, Hepatology and Nutrition, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Dolinsek","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Medical Center Maribor, Maribor, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Mas","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Gastroent\u00e9rologie, H\u00e9patologie, Nutrition, Diab\u00e9tologie et Maladies H\u00e9r\u00e9ditaires, du M\u00e9tabolisme, H\u00f4pital des Enfants, CHU de Toulouse, Toulouse, France"},{"name":"IRSD, Universit\u00e9 de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Miele","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science, Section of Pediatrics, University of Naples \u2018Federico II\u2019, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Orel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Nutrition, Children\u2019s Hospital, University Medical Centre, 1000 Ljubljana, Slovenia"},{"name":"Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Pienar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, \u2018Victor Babes\u2019 University of Medicine and Pharmacy, Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Ribes-Koninckx","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology & Nutrition, La FE University Hospital, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Thomson","sequence":"additional","affiliation":[{"name":"Centre for Paediatric Gastroenterology, Sheffield Children\u2019s Hospital, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Tzivinikos","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Al Jalila Children\u2019s Specialty Hospital, Dubai, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Morrison-Rees","sequence":"additional","affiliation":[{"name":"Medical School, Swansea University, Swansea, Wales, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"John","sequence":"additional","affiliation":[{"name":"Medical School, Swansea University, Swansea, Wales, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J G","family":"Williams","sequence":"additional","affiliation":[{"name":"Medical 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