{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T14:23:39Z","timestamp":1793715819370,"version":"4.6.1"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T00:00:00Z","timestamp":1587772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Broad Medical Research Program at the Crohn\u2019s & Colitis Foundation","award":["514634"],"award-info":[{"award-number":["514634"]}]},{"name":"Crohn\u2019s and Colitis Foundation and European Research Council"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Intestinal microbiota dysbiosis is implicated in Crohn\u2019s disease [CD] and may play an important role in triggering postoperative disease recurrence [POR]. We prospectively studied faecal and mucosal microbial recolonisation following ileocaecal resection to identify the predictive value of recurrence-related microbiota.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Mucosal and\/or faecal samples from 121 CD patients undergoing ileocaecal resection were collected at predefined time points before and after surgery. Ileal biopsies were collected from 39 healthy controls. POR was defined by a Rutgeerts score\u2005\u2265i2b. The microbiota was evaluated by 16S rRNA sequencing. Prediction analysis was performed using C5.0 and Random Forest algorithms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mucosa-associated microbiota in CD patients was characterised by a depletion of butyrate-producing species (false discovery rate [FDR]\u2005&amp;lt;0.01) and enrichment of Proteobacteria [FDR\u2005=\u20050.009] and Akkermansia spp. [FDR\u2005=\u20050.02]. Following resection, a mucosal enrichment of Lachnospiraceae [FDR\u2005&amp;lt;0.001] was seen in all patients but in POR patients, also Fusobacteriaceae [FDR\u2005&amp;lt;0.001] increased compared with baseline. Patients without POR showed a decrease of Streptococcaceae [FDR\u2005=\u20050.003] and Actinomycineae [FDR\u2005=\u20050.06]. The mucosa-associated microbiota profile had good discriminative power to predict POR, and was superior to clinical risk factors. At Month 6, patients experiencing POR had a higher abundance of taxa belonging to Negativicutes [FDR\u2005=\u20050.04] and Fusobacteria [FDR\u2005=\u20050.04] compared with patients without POR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Microbiota recolonisation after ileocaecal resection is different between recurrence and non-recurrence patients, with Fusobacteria as the most prominent player driving early POR. These bacteria involved in the early recolonisation and POR represent a promising therapeutic strategy in the prevention of disease recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjaa081","type":"journal-article","created":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T19:10:17Z","timestamp":1587669017000},"page":"1535-1546","source":"Crossref","is-referenced-by-count":56,"title":["Early Postoperative Endoscopic Recurrence in Crohn\u2019s Disease Is Characterised by Distinct Microbiota Recolonisation"],"prefix":"10.1093","volume":"14","author":[{"given":"Kathleen","family":"Machiels","sequence":"first","affiliation":[{"name":"Department of Chronic Diseases Metabolism and Ageing, KU Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Pozuelo del R\u00edo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Vall d\u2019Hebron Research Institute, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Martinez-De la Torre","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Vall d\u2019Hebron Research Institute, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Vall d\u2019Hebron Research Institute, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vict\u00f2ria","family":"Pascal Andreu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Vall d\u2019Hebron Research Institute, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Sabino","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases Metabolism and Ageing, KU Leuven, Leuven, Belgium"},{"name":"Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Santiago","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Vall d\u2019Hebron Research Institute, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Campos","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Vall d\u2019Hebron Research Institute, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Wolthuis","sequence":"additional","affiliation":[{"name":"Department of Abdominal Surgery, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"D\u2019Hoore","sequence":"additional","affiliation":[{"name":"Department of Abdominal Surgery, University Hospitals Leuven, Leuven, 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