{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:37:23Z","timestamp":1791837443515,"version":"4.3.4"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Litwin IBD Pioneers"},{"name":"Crohn\u2019s and Colitis Foundation and Alberta\u2019s Collaboration of Excellence for Nutrition in Digestive Diseases"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Crohn\u2019s disease [CD] is associated with alterations in gut microbial composition and function. The present controlled-intervention study investigated the relationship between patterns of dietary intake and baseline gut microbiota in CD patients in remission and examined the effects of a dietary intervention in patients consuming a non-diversified diet [NDD].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty outpatients with quiescent CD were recruited in Calgary, Alberta, Canada. Based on 3-day food records, patients consuming a lower plant-based and higher red and processed meat-based diet were assigned to the NDD group [n\u2005=\u200515] and received a 12-week structured dietary intervention; all other patients were assigned to the diversified diet [DD] control group [n\u2005=\u200525] and received conventional management. Faecal microbiota composition, short chain fatty acids [SCFAs] and calprotectin were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At baseline the NDD and DD groups had a different faecal microbial beta-diversity [p\u2005=\u20050.003, permutational multivariate analysis of variance]. The NDD group had lower Faecalibacterium and higher Escherichia\/Shigella relative abundances compared to the DD group [3.3\u2005\u00b1\u20055.4% vs. 8.5\u2005\u00b1\u200510.6%; 6.9\u2005\u00b1\u200512.2% vs. 1.6\u2005\u00b1\u20054.4%; p\u2005\u2264\u20050.03, analysis of covariance]. These two genera showed a strong negative correlation [rs = \u22120.60, q\u2005=\u20050.0002]. Faecal butyrate showed a positive correlation with Faecalibacterium [rs = 0.52, q\u2005=\u20050.002], and an inhibitory relationship with Escherichia\/Shigella abundance [four-parameter sigmoidal model, R = \u22120.83; rs = \u22120.44, q\u2005=\u20050.01], respectively. After the 12 weeks of dietary intervention, no difference in microbial beta-diversity between the two groups was observed [p\u2005=\u20050.43]. The NDD group demonstrated an increase in Faecalibacterium [p\u2005&amp;lt;\u20050.05, generalized estimated equation model], and resembled the DD group at the end of the intervention [p\u2005=\u20050.84, t-test with permutation]. We did not find an association of diet with faecal SCFAs or calprotectin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dietary patterns are associated with specific gut microbial compositions in CD patients in remission. A diet intervention in patients consuming a NDD modifies gut microbial composition to resemble that seen in patients consuming a DD. These results show that diet is important in shaping the microbial dysbiosis signature in CD towards a balanced community.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjaa084","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T15:10:28Z","timestamp":1587481828000},"page":"1547-1557","source":"Crossref","is-referenced-by-count":80,"title":["A Diversified Dietary Pattern Is Associated With a Balanced Gut Microbial Composition of Faecalibacterium and Escherichia\/Shigella in Patients With Crohn\u2019s Disease in Remission"],"prefix":"10.1093","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6977-4309","authenticated-orcid":false,"given":"Zhengxiao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Alberta, Edmonton, AB, 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