{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:18:21Z","timestamp":1790144301730,"version":"4.0.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Jessie and Thomas Tam Foundation"},{"name":"Abbvie Pharmaceuticals"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Elderly-onset inflammatory bowel disease [IBD], defined as age\u2005\u226560 at diagnosis, is increasing worldwide. We aimed to compare clinical characteristics and natural history of elderly-onset IBD patients with those of adult-onset IBD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with a confirmed diagnosis of IBD from 1981 to 2016 were identified from a territory-wide Hong Kong IBD registry involving 13 hospitals. Demographics, comorbidities, clinical features, and outcomes of elderly-onset IBD patients were compared with those of adult-onset IBD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 2413 patients were identified, of whom 270 [11.2%] had elderly-onset IBD. Median follow-up duration was 111 months (interquartile range [IQR]: 68\u2013165 months). Ratio of ulcerative colitis [UC]: Crohn\u2019s disease [CD] was higher in elderly-onset IBD than in adult-onset IBD patients [3.82:1 vs 1.39:1; p\u2005&amp;lt;0.001]. Elderly-onset CD had less perianal involvement [5.4% vs 25.4%; p\u2005&amp;lt;0.001] than adult-onset CD. Elderly-onset IBD patients had significantly lower cumulative use of immunomodulators [p\u2005=\u20050.001] and biologics [p\u2005=\u20050.04]. Elderly-onset IBD was associated with higher risks of: cytomegalovirus colitis (odds ratio [OR]: 3.07; 95% confidence interval [CI] 1.92\u20134.89; p\u2005&amp;lt;0.001); herpes zoster [OR: 2.42; 95% CI 1.22\u20134.80; p\u2005=\u20050.12]; and all cancer development [hazard ratio: 2.97; 95% CI 1.84\u20134.79; p\u2005&amp;lt;0.001]. They also had increased number of overall hospitalisations [OR: 1.14; 95% CI 1.09\u20131.20; p\u2005&amp;lt;0.001], infections-related hospitalisation [OR: 1.87; 95% CI 1.47\u20132.38; p\u2005&amp;lt;0.001], and IBD-related hospitalisation [OR: 1.09; 95% CI 1.04- 1.15; p\u2005=\u20050.001] compared with adult-onset IBD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Elderly-onset IBD was associated with increased risk of infections and cancer development, and increased infection- and IBD-related hospitalisations. Specific therapeutic strategies to target this special population are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjaa181","type":"journal-article","created":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T07:14:07Z","timestamp":1599290047000},"page":"401-408","source":"Crossref","is-referenced-by-count":52,"title":["Epidemiology and Natural History of Elderly-onset Inflammatory Bowel Disease: Results From a Territory-wide Hong Kong IBD Registry"],"prefix":"10.1093","volume":"15","author":[{"given":"Joyce Wing Yan","family":"Mak","sequence":"first","affiliation":[{"name":"Department of Medicine and Therapeutics, Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Lok Tung Ho","sequence":"additional","affiliation":[{"name":"Imperial College School of Medicine, London, 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Pamela Youde Nethersole Eastern Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven Woon Choy","family":"Tsang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Tseung Kwan O Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin Hok Shing","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Medicine and Geriatrics, Caritas Medical Centre, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kam Hon","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicine, North District Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belsy C Y","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Medicine and Geriatrics, Kwong Wah Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aric Josun","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai Hung","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Medicine, Yan Chai Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siew Chien","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"key":"2021031010463637500_CIT0001","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1053\/j.gastro.2011.10.001","article-title":"Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic 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