{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:56:36Z","timestamp":1790650596420,"version":"4.1.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T00:00:00Z","timestamp":1602201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>As no population-based study has investigated the susceptibility and disease course of COVID-19 among patients with inflammatory bowel diseases [IBD], we aimed to investigate this topic in a population-based setting.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Two cohorts were investigated. First, a nationwide cohort of all IBD patients diagnosed with COVID-19 was prospectively followed to investigate the disease courses of both diseases. Second, within a population-based cohort of 2.6 million Danish citizens, we identified all individuals tested for SARS-CoV-2 to determine the occurrence of COVID-19 among patients with and without IBD and other immune-mediated inflammatory diseases [IMIDs].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Between January 28, 2020 and June 2, 2020, a total of 76 IBD patients with COVID-19 were identified in the national cohort and prospectively followed for 35 days (interquartile range [IQR]: 25\u201351). A large proportion [n\u2005=\u200519: 25%] required a COVID-19-related hospitalisation for 7 days [IQR: 2\u20138.5] which was associated with being 65 years or older (odds ratio [OR]\u2005=\u200523].80, 95% confidence interval [CI] 6.32\u201389.63, p\u2005&amp;lt;0.01) and presence of any non-IMID comorbidity [OR\u2005=\u20058.12, 95% CI 2.55\u201325.87, p\u2005&amp;lt;0.01], but not use of immunomodulators [p\u2005=\u20050.52] or biologic therapies [p\u2005=\u20050.14]. In the population-based study, 8476 of 231 601 [3.7%] residents tested positive for SARS-CoV-2; however, the occurrence was significantly lower among patients with IBD [62 of the 2486 patients\u2005=\u20052.5%, p\u2005&amp;lt;0.01] and other IMIDs [531 of 16 492 patients\u2005=\u20053.2%, p\u2005&amp;lt;0.01] as compared with patients without IMIDs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Patients with IMIDs, including IBD, had a significantly lower susceptibility to COVID-19 than patients without IMIDs, and neither immunosuppressive therapies nor IBD activity were associated with the disease course of COVID-19.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjaa205","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T19:15:37Z","timestamp":1601925337000},"page":"540-550","source":"Crossref","is-referenced-by-count":62,"title":["Prevalence and Outcomes of COVID-19 Among Patients With Inflammatory Bowel Disease\u2014A Danish Prospective Population-based Cohort Study"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0323-7030","authenticated-orcid":false,"given":"Mohamed","family":"Attauabi","sequence":"first","affiliation":[{"name":"Gastrounit, Medical Division, Hvidovre University Hospital, Hvidovre, Denmark"},{"name":"Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, University of Copenhagen, Hvidovre Hospital, Hvidovre, Denmark"},{"name":"Department of Gastroenterology and Hepatology, Herlev Hospital, University of Copenhagen, 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