{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:32:52Z","timestamp":1790040772556,"version":"4.0.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"COVID-19 LINEA 1 REGIONE LOMBARDIA DG RICERCA","award":["PR-0375"],"award-info":[{"award-number":["PR-0375"]}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["SFB1181"],"award-info":[{"award-number":["SFB1181"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["SFB\/TRR241"],"award-info":[{"award-number":["SFB\/TRR241"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The German Research Council"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>A similar course of COVID-19 in patients with inflammatory bowel diseases [IBD] and in the general population has been reported. However, disease prevalence in IBD patients is presently unknown. In this prospective observational study, we aimed at determining SARS-CoV2 infection prevalence in IBD patients treated with biologic therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From IBD patients under biologic therapy and recruited from three different locations in Italy and Germany, 354 sera were evaluated for antibody presence by RBD ELISA. Control groups were: i] age-matched healthy subjects tested in the same time period in Milan, Italy; ii] healthy subjects collected in the pre-COVID era; iii] IBD patients under biologic therapy collected in the pre-COVID era.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight out of 354 patients tested positive for the anti-RBD-SARS-CoV2 IgG antibody [prevalence 2.3%]. The percentage of IgG-positive patients among those recruited from Milan was significantly higher than among those recruited from other locations [prevalence 5.4% vs 0.4%, p\u2005&amp;lt;0.005]. IgG-positive patients reported a significantly higher incidence of fever, anosmia, and ageusia, and were more likely to have entered into close contact with COVID-19-positive subjects before the study enrolment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Seroprevalence of SARS-CoV2 in IBD patients treated with biologic therapy reflects values measured in the local general population. Specific symptoms and contact history with SARS-CoV2-infected individuals strongly increase the likelihood of SARS-CoV2 seropositivity.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjaa237","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T05:52:48Z","timestamp":1605678768000},"page":"864-868","source":"Crossref","is-referenced-by-count":19,"title":["Seroprevalence of SARS-CoV2 in IBD Patients Treated with Biologic Therapy"],"prefix":"10.1093","volume":"15","author":[{"given":"Roberto","family":"Berte\u2019","sequence":"first","affiliation":[{"name":"Gastroenterology and Endoscopy Unit, Fondazione IRCCS C\u00e0 Granda, Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9068-3209","authenticated-orcid":false,"given":"Stefano","family":"Mazza","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit, Fondazione IRCCS C\u00e0 Granda, Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Rachele","family":"Stefanucci","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit, Fondazione IRCCS C\u00e0 Granda, Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Noviello","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit, Fondazione IRCCS C\u00e0 Granda, Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Costa","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit, Fondazione IRCCS C\u00e0 Granda, Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clorinda","family":"Ciafardini","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit, Fondazione IRCCS C\u00e0 Granda, Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Mileti","sequence":"additional","affiliation":[{"name":"European Institute of Oncology IRCCS, Department of Experimental Oncology, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Mapelli","sequence":"additional","affiliation":[{"name":"European Institute of Oncology IRCCS, Department of Experimental Oncology, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Pasqualato","sequence":"additional","affiliation":[{"name":"European Institute of Oncology IRCCS, Department of Experimental Oncology, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Pinto","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Duilio Casula Hospital, AOU Cagliari, Cagliari CA, Italy"},{"name":"Department of Medical Science and Public Health, University of Cagliari, Cagliari CA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnese","family":"Favale","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Duilio Casula Hospital, AOU Cagliari, Cagliari CA, Italy"},{"name":"Department of Medical Science and Public Health, University of Cagliari, Cagliari CA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Vecchi","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit, Fondazione IRCCS C\u00e0 Granda, Ospedale Maggiore Policlinico, Milan, Italy"},{"name":"Department of Pathophysiology and Transplantation, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus F","family":"Neurath","sequence":"additional","affiliation":[{"name":"Deutsches Zentrum fuer Immuntherapie [DZI], FAU Erlangen-Nuremberg and Universit\u00e4tsklinikum Erlangen, Ulmenweg, Germany"},{"name":"Department of Internal Medicine 1, FAU Erlangen-Nuremberg and Universit\u00e4tsklinikum Erlangen, Ulmenweg. 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