{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:58:21Z","timestamp":1791838701328,"version":"4.3.4"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Medical Department I, University Medical Center Schleswig Holstein, Campus Kiel, Kiel, Germany"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Increased mortality from respiratory diseases was observed in epidemiological studies of patients with ulcerative colitis [UC] as a potentially underestimated extraintestinal manifestation. We therefore investigated the presence of pulmonary manifestations of inflammatory bowel disease [IBD] and the potential effect of tumour necrosis factor alpha [TNF-\u03b1] inhibitors on pulmonary function tests [PFT] in a prospective, longitudinal study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In all, 92 consecutive patients with IBD (49 Crohn\u00b4s disease [CD], 43 UC) and 20 healthy controls were recruited. Fifty patients with IBD were in remission, and 42 had active disease with 22 of these being examined before and 6 weeks after initiating anti-TNF therapy. Pulmonary function tests [PFT] were evaluated using the Medical Research Council [MRC] dyspnoea index and a standardized body plethysmography. IBD activity was assessed using Harvey-Bradshaw index for CD and partial Mayo score for UC. Data are presented as mean \u00b1 standard error of the mean [SEM].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with active IBD showed significant reduction of PFT. Forced expiration [Tiffeneau index] values [FEV1%] were significantly reduced in IBD patients with active disease [78.8 \u00b1 1.1] compared with remission [86.1 \u00b1 0.9; p = 0.0002] and with controls [87.3 \u00b1 1.3; p = 0.001]. Treatment with anti-TNF induced a significant relief in obstruction [p = 0.003 for FEV1% in comparison with baseline levels]. The level of pulmonary obstruction significantly correlated with clinical inflammation scores [HBI or Mayo].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions: Patients<\/jats:title>\n                    <jats:p>with active IBD present with significant obstructive abnormalities in their PFTs. Obstruction is related to inflammatory activity, with anti-TNF improving PFTs. Pulmonary obstruction and possibly chronic bronchopulmonary inflammation is an overlooked problem in active IBD that is probably obscured by intestinal symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjab024","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T00:35:19Z","timestamp":1612398919000},"page":"1339-1345","source":"Crossref","is-referenced-by-count":16,"title":["Subclinical Pulmonary Involvement in Active IBD Responds to Biologic Therapy"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5817-5589","authenticated-orcid":false,"given":"M","family":"Ellrichmann","sequence":"first","affiliation":[{"name":"Medical Department I, University Medical Center Schleswig Holstein, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Bethge","sequence":"additional","affiliation":[{"name":"Medical Department I, University Medical Center Schleswig Holstein, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Boesenkoetter","sequence":"additional","affiliation":[{"name":"Medical Department I, University Medical Center Schleswig Holstein, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Conrad","sequence":"additional","affiliation":[{"name":"Medical Department I, University Medical Center Schleswig Holstein, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Noth","sequence":"additional","affiliation":[{"name":"Medical Department I, University Medical Center Schleswig Holstein, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Bahmer","sequence":"additional","affiliation":[{"name":"Medical Department I, University Medical Center Schleswig Holstein, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Nikolaus","sequence":"additional","affiliation":[{"name":"Medical Department I, University Medical Center Schleswig Holstein, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Aden","sequence":"additional","affiliation":[{"name":"Medical Department I, University Medical Center Schleswig Holstein, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Zeissig","sequence":"additional","affiliation":[{"name":"Department of Medicine I, University Medical Center Dresden, and Center for Regenerative Therapies Dresden [CRTD], Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Medical Department I, University Medical Center Schleswig Holstein, Kiel, 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