{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:18:04Z","timestamp":1787008684920,"version":"build-2736575974"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T00:00:00Z","timestamp":1613260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"K23 Career Development","award":["K23KD111995-01A1"],"award-info":[{"award-number":["K23KD111995-01A1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Incidentally diagnosed terminal ileitis [IDTI] has been reported among asymptomatic persons undergoing non-diagnostic colonoscopy. The purpose of our study was to determine the prevalence and long-term outcomes of asymptomatic terminal ileitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a systematic review using three biomedical databases [Medline, Embase, and Web of Science] and relevant scientific meeting abstracts. We identified observational studies that reported the prevalence of IDTI in adults undergoing screening or polyp surveillance colonoscopy and\/or the long-term outcomes of such lesions. A random-effects meta-analysis was conducted to determine the pooled prevalence rate of IDTI. The progression of IDTI to overt Crohn\u2019s disease [CD] was also described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 2388 eligible studies, 1784 were screened after excluding duplicates, 84 were reviewed in full text, and 14 studies were eligible for inclusion. Seven studies reported the prevalence of IDTI in 44 398 persons undergoing non-diagnostic colonoscopy, six studies reported follow-up data, and one study reported both types of data. The pooled prevalence rate of IDTI was 1.6% (95% confidence interval [CI] 0.1\u201321.8%) with significant heterogeneity [I2\u2005=\u200599.7]. Among patients who had undergone non-diagnostic colonoscopy and had follow-up data [range 13\u201384 months reported in five studies], progression to overt CD was rare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IDTI is not uncommon on non-diagnostic colonoscopies. Based on limited data, the rate of its progression to overt CD seems low, and watchful waiting is likely a reasonable strategy. Further long-term follow-up studies are needed to inform the natural history of incidental terminal ileitis, factors that predict progression to CD, and therapeutic implications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjab030","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T22:35:20Z","timestamp":1612910120000},"page":"1455-1463","source":"Crossref","is-referenced-by-count":21,"title":["Prevalence and Progression of Incidental Terminal Ileitis on Non-diagnostic Colonoscopy: A Systematic Review and Meta-analysis"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4729-1485","authenticated-orcid":false,"given":"Manasi","family":"Agrawal","sequence":"first","affiliation":[{"name":"Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario Bento-","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hospital and University Center of Coimbra, Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Walsh","sequence":"additional","affiliation":[{"name":"Levy Library, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1536-8436","authenticated-orcid":false,"given":"Neeraj","family":"Narula","sequence":"additional","affiliation":[{"name":"Department of Medicine [Division of Gastroenterology] and Farncombe Family Digestive Health Research Institute; McMaster University, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6472-249X","authenticated-orcid":false,"given":"Jean-Frederic","family":"Colombel","sequence":"additional","affiliation":[{"name":"Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan C","family":"Ungaro","sequence":"additional","affiliation":[{"name":"Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,2,14]]},"reference":[{"key":"2021092515421728400_CIT0001","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1001\/jama.2016.5989","article-title":"Screening for colorectal Cancer: US preventive services task force recommendation statement","volume":"315","author":"Bibbins-Domingo","year":"2016","journal-title":"JAMA"},{"key":"2021092515421728400_CIT0002","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3322\/caac.21457","article-title":"Colorectal cancer screening for average-risk adults: 2018 guideline update from the American Cancer Society","volume":"68","author":"Wolf","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"2021092515421728400_CIT0003","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1053\/j.gastro.2012.06.001","article-title":"Guidelines for colonoscopy surveillance after screening and polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer","volume":"143","author":"Lieberman","year":"2012","journal-title":"Gastroenterology"},{"key":"2021092515421728400_CIT0004","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1002\/cncr.28794","article-title":"Estimating the magnitude of colorectal cancers prevented during the era of screening: 1976 to 2009","volume":"120","author":"Yang","year":"2014","journal-title":"Cancer"},{"key":"2021092515421728400_CIT0005","doi-asserted-by":"crossref","first-page":"l6090","DOI":"10.1136\/bmj.l6090","article-title":"Variation in post-colonoscopy colorectal cancer across colonoscopy providers in English National Health Service: population based cohort study","volume":"367","author":"Burr","year":"2019","journal-title":"BMJ"},{"key":"2021092515421728400_CIT0006","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1136\/gutjnl-2018-317124","article-title":"Participation and yield of a population-based colorectal cancer screening programme in China","volume":"68","author":"Chen","year":"2019","journal-title":"Gut"},{"key":"2021092515421728400_CIT0007","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews 2020","author":"Page","year":"2020"},{"key":"2021092515421728400_CIT0008","year":"2020"},{"key":"2021092515421728400_CIT0009"},{"key":"2021092515421728400_CIT0010","author":"Ryan"},{"key":"2021092515421728400_CIT0011","author":"Wells"},{"key":"2021092515421728400_CIT0012","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/1471-2458-13-154","article-title":"Are healthcare workers\u2019 intentions to vaccinate related to their knowledge, beliefs and attitudes? A systematic review","volume":"13","author":"Herzog","year":"2013","journal-title":"BMC Public Health"},{"key":"2021092515421728400_CIT0013","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.cgh.2017.11.006","article-title":"Characteristics and progression of preclinical inflammatory bowel disease","volume":"16","author":"Rodr\u00edguez-Lago","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2021092515421728400_CIT0014","first-page":"1441","article-title":"Diagnostic yield of routine ileoscopy","volume":"90","author":"Zwas","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"2021092515421728400_CIT0015","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.dld.2010.08.004","article-title":"Ileal biopsy: clinical indications, endoscopic and histopathologic findings in 10,000 patients","volume":"43","author":"Melton","year":"2011","journal-title":"Dig Liver Dis"},{"key":"2021092515421728400_CIT0016","doi-asserted-by":"crossref","first-page":"S422","DOI":"10.1093\/ecco-jcc\/jju027.799","article-title":"Incidence of endoscopically and histologically confirmed ileal ulceration in a sequential cohort of patients undergoing screening colonoscopy as part of the UK Bowel Cancer Screening Programme","volume":"9","author":"McDonnell","year":"2015","journal-title":"J Crohns Colitis"},{"key":"2021092515421728400_CIT0017","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/MEG.0000000000001065","article-title":"Is ileocecal valve intubation essential for routine colonoscopic examination?","volume":"30","author":"Meral","year":"2018","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2021092515421728400_CIT0018","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1007\/s00464-008-9843-x","article-title":"Routine ileal intubation during screening colonoscopy: a useful maneuver?","volume":"22","author":"Kennedy","year":"2008","journal-title":"Surg Endosc"},{"key":"2021092515421728400_CIT0019","doi-asserted-by":"crossref","first-page":"S630","DOI":"10.1016\/S0016-5085(13)62335-5","article-title":"Incidental diagnosis of inflammatory bowel disease in a British bowel cancer screening cohort: a multi-centre study","volume":"144","author":"Butcher","year":"2013","journal-title":"Gastroenterology"},{"key":"2021092515421728400_CIT0020","doi-asserted-by":"crossref","article-title":"Prevalence of inflammatory bowel disease [IBD] in a colorectal cancer population screening program.","author":"Bezzio","DOI":"10.1055\/s-0039-1681785"},{"key":"2021092515421728400_CIT0021","doi-asserted-by":"crossref","first-page":"S768","DOI":"10.14309\/00000434-201510001-01809","article-title":"Terminal ileitis of unknown significance: long-term follow-up and outcomes in a single cohort of patients","volume":"110","author":"Siddiki","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"2021092515421728400_CIT0022","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1097\/PAS.0b013e3181ad25b6","article-title":"Isolated asymptomatic ileitis does not progress to overt Crohn disease on long-term follow-up despite features of chronicity in ileal biopsies","volume":"33","author":"Courville","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"2021092515421728400_CIT0023","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-230X-11-51","article-title":"Long-term follow-up of nonspecific small bowel ulcers with a benign course and no requirement for surgery: is this a distinct group?","volume":"11","author":"Wang","year":"2011","journal-title":"BMC Gastroenterol"},{"key":"2021092515421728400_CIT0024","first-page":"7","article-title":"The analysis of factors associated with progression of isolated terminal ileal lesions","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"key":"2021092515421728400_CIT0025","first-page":"552","article-title":"Long-term clinical outcome of isolated terminal ileal lesions","volume":"33","author":"Kang","year":"2018","journal-title":"J Gastroenterol Hepatol"},{"key":"2021092515421728400_CIT0026","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1093\/ibd\/17.supplement1.S31b","article-title":"Long follow-up of patients with isolated ileal erosions and its relationship with Crohn\u2019s disease","volume":"17","author":"Castano","year":"2011","journal-title":"Inflamm Bowel Dis"},{"key":"2021092515421728400_CIT0027","doi-asserted-by":"crossref","DOI":"10.1111\/jgh.14997","article-title":"Terminal ileum intubation is not associated with colonoscopy quality measures","author":"Leiman","year":"2020","journal-title":"J Gastroenterol Hepatol"},{"key":"2021092515421728400_CIT0028","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/01.mcg.0000210104.59370.66","article-title":"Asymptomatic ileitis: past, present, and future","volume":"40","author":"Greaves","year":"2006","journal-title":"J Clin Gastroenterol"},{"key":"2021092515421728400_CIT0029","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/BF02242995","article-title":"Clinically silent inflammatory gut lesions in undifferentiated spondyloarthropathies","volume":"13","author":"Altomonte","year":"1994","journal-title":"Clin Rheumatol"},{"key":"2021092515421728400_CIT0030","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/art.1780370105","article-title":"High frequency of silent inflammatory bowel disease in spondylarthropathy","volume":"37","author":"Leirisalo-Repo","year":"1994","journal-title":"Arthritis Rheum"},{"key":"2021092515421728400_CIT0031","doi-asserted-by":"crossref","first-page":"350","DOI":"10.7326\/0003-4819-156-5-201203060-00007","article-title":"Aspirin, nonsteroidal anti-inflammatory drug use, and risk for Crohn disease and ulcerative colitis: a cohort study","volume":"156","author":"Ananthakrishnan","year":"2012","journal-title":"Ann Intern Med"},{"key":"2021092515421728400_CIT0032","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/MCG.0000000000000421","article-title":"Role of nonsteroidal anti-inflammatory drugs in exacerbations of inflammatory bowel disease","volume":"50","author":"Long","year":"2016","journal-title":"J Clin Gastroenterol"}],"container-title":["Journal of Crohn's and Colitis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ecco-jcc\/advance-article-pdf\/doi\/10.1093\/ecco-jcc\/jjab030\/38852051\/jjab030.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/15\/9\/1455\/40440477\/jjab030.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/15\/9\/1455\/40440477\/jjab030.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T11:43:02Z","timestamp":1632570182000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article\/15\/9\/1455\/6134781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,14]]},"references-count":32,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,2,14]]},"published-print":{"date-parts":[[2021,9,25]]}},"URL":"https:\/\/doi.org\/10.1093\/ecco-jcc\/jjab030","relation":{},"ISSN":["1873-9946","1876-4479"],"issn-type":[{"value":"1873-9946","type":"print"},{"value":"1876-4479","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,9,1]]},"published":{"date-parts":[[2021,2,14]]}}}