{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:31:15Z","timestamp":1790184675728,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100021339","name":"Biocruces Bizkaia Health Research Institute","doi-asserted-by":"crossref","award":["INT-BC-2018-007"],"award-info":[{"award-number":["INT-BC-2018-007"]}],"id":[{"id":"10.13039\/501100021339","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Gobierno Vasco-Eusko Jaurlaritza","award":["2020222004"],"award-info":[{"award-number":["2020222004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and aims<\/jats:title>\n                  <jats:p>Crohn\u2019s disease [CD] can develop penetrating complications at any time during the disease course. Enterocutaneous fistulae [ECF] are disease-related complications with an important impact on quality of life. Our aim was to describe the outcomes of this complication, including its medical and\/or surgical management and their temporal trends. The primary endpoint was fistula closure, defined as the absence of drainage, with no new abscess or surgery, over the preceding 6 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Clinical information from all adult patients with CD and at least one ECF\u2014excluding perianal fistulae\u2014were identified from the prospectively-maintained ENEIDA registry. All additional information regarding treatment for this complication was retrospectively reviewed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 301 ECF in 286 patients [January 1970-September 2020] were analysed out of 30 088 records. These lesions were mostly located in the ileum [67%] and they had a median of one external opening [range 1-10]. After a median follow-up of 146 months (interquartile range [IQR], 69-233), 69% of patients underwent surgery. Fistula closure was achieved in 84%, mostly after surgery, and fistula recurrence was uncommon [13%]. Spontaneous and low-output fistulae were associated with higher closure rates (hazard ratio [HR] 1.51, 95% confidence interval [CI] 1.17-1.93, p\u2005=\u20050.001, and HR 1.49, 95% CI 1.07-2.06, p\u2005=\u20050.03, respectively); this was obtained more frequently with medical therapy since biologics have been available.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>ECF complicating CD are rare but entail a high burden of medical and surgical resources. Closure rates are high, usually after surgery, and fistula recurrence is uncommon. A significant proportion of patients receiving medical therapy can achieve fistula closure.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjac016","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T20:14:21Z","timestamp":1643141661000},"page":"1049-1058","source":"Crossref","is-referenced-by-count":7,"title":["Management and Long-term Outcomes of Crohn\u2019s Disease Complicated with Enterocutaneous Fistula: ECUFIT Study from GETECCU"],"prefix":"10.1093","volume":"16","author":[{"given":"Manuel","family":"Barreiro-de Acosta","sequence":"first","affiliation":[{"name":"Gastroenterology Department, Hospital Cl\u00ednico Universitario de Santiago, Santiago de Compostela , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabino","family":"Riestra","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Universitario Central de Asturias, Instituto de Investigaci\u00f3n Sanitaria del 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