{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:20:58Z","timestamp":1788315658389,"version":"build-2803163510"},"reference-count":97,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inflammatory bowel diseases [IBD], which are associated with a high disease burden, are also reported to be accompanied by a high prevalence of psychiatric disorders. However, the literature on IBD and psychiatric disorders has not been reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This systematic review followed the PRISMA guidelines, and its protocol was registered at PROSPERO [ID: CRD42020214359]. PubMed, Embase and PsycINFO were consulted for the literature search. Studies reporting on diagnosed psychiatric disorders in IBD were included. Pooled prevalence rates were calculated using random effects meta-analyses. Study quality was assessed using the Newcastle\u2013Ottawa Scale [NOS].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty-nine studies were identified with an average cohort size of 60 114 patients. Pooled prevalence rates were: mood disorders, 10% (95% confidence interval [CI] = 7%; 15%); anxiety disorders, 12% [95% CI = 8%; 18%]; substance misuse, 3% [95% CI = 1%; 7%]; psychotic disorders, 2% [95% CI = 1%; 4%]; behavioural disorders, 1% [95% CI = 0%; 3%]; personality disorders, 3% [95% CI = 1%; 10%]; developmental disorders, 1% [95% CI = 0%; 3%]; and behavioural and emotional disorders with onset usually during childhood, 1% [95% CI = 1%; 3%]. All analyses had high statistical heterogeneity [I2 &amp;gt; 99%]. Seven studies reported an increased risk of suicide in IBD patients compared to controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prevalence of psychiatric comorbidities was high [11\u201382%] in patients with IBD and was higher than in the background population. Addressing mental health problems in patients with IBD can improve their adherence to treatment and the somatic disease course and, consequently, reduce morbidity and mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjac095","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T09:17:07Z","timestamp":1656667027000},"page":"1933-1945","source":"Crossref","is-referenced-by-count":38,"title":["Psychiatric Disorders in Adult and Paediatric Patients With Inflammatory Bowel Diseases \u2013 A Systematic Review and Meta-Analysis"],"prefix":"10.1093","volume":"16","author":[{"given":"Laura","family":"Arp","sequence":"first","affiliation":[{"name":"Gastrounit, Medical Section, Copenhagen University Hospital \u2013 Amager and Hvidovre , Hvidovre , Denmark"},{"name":"Copenhagen Centre for Inflammatory Bowel Disease in Children, Adolescent and Adults, Copenhagen University Hospital \u2013 Amager and Hvidovre , Hvidovre , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Jansson","sequence":"additional","affiliation":[{"name":"Copenhagen Centre for Inflammatory Bowel Disease in Children, Adolescent and Adults, Copenhagen University Hospital \u2013 Amager and Hvidovre , Hvidovre , Denmark"},{"name":"The Paediatric Department, Copenhagen University Hospital \u2013 Amager and Hvidovre , Hvidovre , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibeke","family":"Wewer","sequence":"additional","affiliation":[{"name":"Copenhagen Centre for Inflammatory Bowel Disease in Children, Adolescent and Adults, Copenhagen University Hospital \u2013 Amager and Hvidovre , Hvidovre , Denmark"},{"name":"The Paediatric Department, Copenhagen University Hospital \u2013 Amager and Hvidovre , Hvidovre , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Burisch","sequence":"additional","affiliation":[{"name":"Gastrounit, Medical Section, Copenhagen University Hospital \u2013 Amager and Hvidovre , Hvidovre , Denmark"},{"name":"Copenhagen Centre for Inflammatory Bowel Disease in Children, Adolescent and Adults, Copenhagen University Hospital \u2013 Amager and Hvidovre , Hvidovre , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,1]]},"reference":[{"key":"2022120518041211500_CIT0001","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S2468-1253(19)30333-4","article-title":"The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990-2017: a systematic analysis for the global burden of disease study 2017","volume":"5","author":"GBD 2017 Inflammatory Bowel Disease Collaborators","year":"2020","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2022120518041211500_CIT0002","first-page":"2296","article-title":"Low risk of unemployment, sick leave, and work disability among patients with inflammatory bowel disease: a 7-year follow-up study of a Danish inception cohort","volume":"21","author":"Vester-Andersen","year":"2015","journal-title":"Inflamm Bowel Dis"},{"key":"2022120518041211500_CIT0003","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1093\/jcag\/gwy053","article-title":"The impact of inflammatory bowel disease in Canada 2018: extra-intestinal diseases in Ibd","volume":"2","author":"Bernstein","year":"2019","journal-title":"J Can Assoc Gastroenterol"},{"key":"2022120518041211500_CIT0004","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/apt.12659","article-title":"Fatigue is highly associated with poor health-related quality of life, disability and depression in newly-diagnosed patients with inflammatory bowel disease, independent of disease activity","volume":"39","author":"Cohen","year":"2014","journal-title":"Aliment Pharmacol Therap"},{"key":"2022120518041211500_CIT0005","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/apt.14171","article-title":"Systematic review with meta-analysis: the impact of a depressive state on disease course in adult inflammatory bowel disease","volume":"46","author":"Alexakis","year":"2017","journal-title":"Aliment Pharmacol Therap"},{"key":"2022120518041211500_CIT0006","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1053\/j.gastro.2012.10.003","article-title":"Brain\u2013gut interactions in inflammatory bowel disease","volume":"144","author":"Bonaz","year":"2013","journal-title":"Gastroenterology"},{"key":"2022120518041211500_CIT0007","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.cgh.2015.12.045","article-title":"von K\u00e4nel R. 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