{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:46:12Z","timestamp":1793400372127,"version":"4.5.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Endoscopic-post-operative-recurrence [ePOR] in Crohn\u2019s disease [CD] after ileocecal resection [ICR] is a major concern. We aimed to evaluate the effectiveness of early prophylaxis with biologics and to compare anti-tumour necrosis factor [anti-TNF] therapy to vedolizumab [VDZ] and ustekinumab [UST] in a real-world setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective multicentre study of CD-adults after curative ICR on early prophylaxis was undertaken. ePOR was defined as a Rutgeerts score [RS] \u2265 i2 or colonic-segmental-SES-CD \u2265 6. Multivariable logistic regression was used to evaluate risk factors, and inverse probability treatment weighting [IPTW] was applied to compare the effectiveness between agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 297 patients (53.9% males, age at diagnosis 24 years [19\u201332], age at ICR 34 years [26\u201343], 18.5% smokers, 27.6% biologic-na\u00efve, 65.7% anti-TNF experienced, 28.6% two or more biologics and 17.2% previous surgery). Overall, 224, 39 and 34 patients received anti-TNF, VDZ or UST, respectively. Patients treated with VDZ and UST were more biologic experienced with higher rates of previous surgery. ePOR rates within 1 year were 41.8%. ePOR rates by treatment groups were: anti-TNF 40.2%, VDZ 33% and UST 61.8%. Risk factors for ePOR at 1 year were: past-infliximab (adjusted odds ratio [adj.OR] = 1.73 [95% confidence interval, CI: 1.01\u20132.97]), past-adalimumab [adj.OR = 2.32 [95% CI: 1.35-4.01] and surgical aspects. After IPTW, the risk of ePOR within 1 year of VDZ vs anti-TNF or UST vs anti-TNF was comparable (OR = 0.55 [95% CI: 0.25\u20131.19], OR = 1.86 [95% CI: 0.79\u20134.38]), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Prevention of ePOR within 1 year after surgery was successful in ~60% of patients. Patients treated with VDZ or UST consisted of a more refractory group. After controlling for confounders, no differences in ePOR risk were seen between anti-TNF prophylaxis and other groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjac100","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T11:29:03Z","timestamp":1658921343000},"page":"1882-1892","source":"Crossref","is-referenced-by-count":59,"title":["Endoscopic Postoperative Recurrence in Crohn\u2019s Disease After Curative Ileocecal Resection with Early Prophylaxis by Anti-TNF, Vedolizumab or Ustekinumab: A Real-World Multicentre European Study"],"prefix":"10.1093","volume":"16","author":[{"given":"Henit","family":"Yanai","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Rabin Medical Center , Petah Tikva , Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kagramanova","sequence":"additional","affiliation":[{"name":"Moscow Clinical Scientific Centre named after. A.S. Loginov , Moscow , Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg","family":"Knyazev","sequence":"additional","affiliation":[{"name":"Moscow Clinical Scientific Centre named after. A.S. Loginov , Moscow , Russian Federation"},{"name":"State Scientific Centre of Coloproctology named after A.N. Ryzhyh , Moscow , Russian Federation"},{"name":"Research Institute of Health Organization and Medical Management , Moscow , Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Sabino","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospitals of Leuven , Leuven , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shana","family":"Haenen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospitals of Leuven , Leuven , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerassimos J","family":"Mantzaris","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, GHA \u2018Evaggelismos-Ophthalmiatreion Athinon-Polykliniki\u2019 , Athens , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Mountaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, GHA \u2018Evaggelismos-Ophthalmiatreion Athinon-Polykliniki\u2019 , Athens , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Armuzzi","sequence":"additional","affiliation":[{"name":"IBD Center, IRCCS Humanitas Research Hospital, Rozzano , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Pugliese","sequence":"additional","affiliation":[{"name":"CEMAD, IBD UNIT, Unit\u00e0 Operativa Complessa di Medicina Interna e Gastroenterologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario \u2018A. Gemelli\u2019 IRCCS , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Furfaro","sequence":"additional","affiliation":[{"name":"IBD Center, Humanitas Research Hospital-IRCCS , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5623-2968","authenticated-orcid":false,"given":"Gionata","family":"Fiorino","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2734-675X","authenticated-orcid":false,"given":"David","family":"Drobne","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical Faculty, University of Ljubljana , Ljubljana , Slovenia"},{"name":"Department of Gastroenterology, University Medical Centre Ljubljana , Ljubljana , 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