{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:32:10Z","timestamp":1779309130365,"version":"3.51.4"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100005881","name":"Ministry of Human Capacities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005881","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>The number of population-based studies in ulcerative colitis [UC] from Eastern Europe is limited. Our aim here was to analyse the incidence, prevalence, disease phenotype, treatment strategy, disease course and colectomy rates in a prospective population-based inception cohort including UC patients diagnosed between 2007 and 2018. The present study is a continuation of the Veszprem IBD cohort since 1977.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 467 UC patients were included [male\/female: 236\/231; median age at diagnosis: 36 years, IQR: 25\u201354 years]. Both in-hospital and outpatient records were collected and comprehensively reviewed. The mean length of follow-up was 8.34\u2005\u00b1\u20053.6 years. Demographic data were derived from the Hungarian Central Statistical Office.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean incidence rate was 11.02\/105 person-years in this 12-year period. Prevalence was 317.79\/105 persons in 2015. Disease extent at diagnosis was proctitis [E1] in 22.3%, left-sided colitis [E2] in 43.9% and extensive colitis [E3] in 33.8%. The probability of disease extent progression was 11.6% [SE: 1.8] after 5 years. The distribution of maximal therapeutic steps was 5-ASA in 46.9%, corticosteroids in 16.3%, immunosuppressives in 19.3% and biologicals in 16.5%. The probability of receiving biological therapy after diagnosis was 9.9% [SE: 1.4] at 3 years. The overall colectomy rate was 4.1% in the population. The probability of colectomy was 1.5% [SE: 0.6] at 1 year, 3.6% [SE: 0.9] at 5 years and 4.4% [SE: 1.0] at 10 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of UC was high in Hungary, similar to high-incidence areas in Western Europe. Treatment strategies are in line with the biological era. The probability of progressing to proximal disease, and the medium- and long-term colectomy rates were both lower compared with data from Western European centres.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjac142","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T11:46:38Z","timestamp":1663674398000},"page":"352-360","source":"Crossref","is-referenced-by-count":11,"title":["Epidemiology, Treatment Strategy, Natural Disease Course and Surgical Outcomes of Patients with Ulcerative Colitis in Western Hungary \u2013 A Population-based Study Between 2007 and 2018: Data from the Veszprem County Cohort"],"prefix":"10.1093","volume":"17","author":[{"given":"Zsuzsanna","family":"Kurti","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Oncology, Semmelweis University , Budapest , Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorant","family":"Gonczi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Oncology, Semmelweis University , Budapest , Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laszlo","family":"Lakatos","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Ferenc Csolnoky Hospital , Veszprem , Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra A","family":"Golovics","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hungarian Defence Forces Medical Centre , Budapest , Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tunde","family":"Pandur","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Grof Eszterhazy Hospital , Papa , Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyula","family":"David","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Ferenc Csolnoky Hospital , Veszprem , Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsuzsanna","family":"Erdelyi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Ferenc Csolnoky Hospital , Veszprem , Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istvan","family":"Szita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Ferenc Csolnoky Hospital , Veszprem , Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3948-6488","authenticated-orcid":false,"given":"Peter L","family":"Lakatos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Oncology, Semmelweis University , Budapest , Hungary"},{"name":"Division of Gastroenterology, McGill University Health Center , Montreal, Quebec , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,9,19]]},"reference":[{"key":"2023040316020473000_","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.gtc.2020.07.005","article-title":"Epidemiology and pathogenesis of ulcerative colitis","volume":"49","author":"Du","year":"2020","journal-title":"Gastroenterol Clin North Am"},{"key":"2023040316020473000_","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1053\/j.gastro.2011.10.001","article-title":"Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review","volume":"142","author":"Molodecky","year":"2012","journal-title":"Gastroenterology"},{"key":"2023040316020473000_","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/1751-2980.12449","article-title":"Epidemiology of inflammatory bowel diseases from west to east","volume":"18","author":"Vegh","year":"2017","journal-title":"J Dig Dis"},{"key":"2023040316020473000_","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3748\/wjg.v10.i3.404","article-title":"Striking elevation in incidence and prevalence of inflammatory bowel disease in a province of western Hungary between 1977\u20132001","volume":"10","author":"Lakatos","year":"2004","journal-title":"World J Gastroenterol"},{"key":"2023040316020473000_","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1002\/ibd.21607","article-title":"Incidence, disease phenotype at diagnosis, and early disease course in inflammatory bowel diseases in Western Hungary, 2002\u20132006","volume":"17","author":"Lakatos","year":"2011","journal-title":"Inflamm Bowel Dis"},{"key":"2023040316020473000_","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1136\/gutjnl-2013-304636","article-title":"EpiCom-group. East\u2013West gradient in the incidence of inflammatory bowel disease in Europe: the ECCO-EpiCom inception cohort","volume":"63","author":"Burisch","year":"2014","journal-title":"Gut"},{"key":"2023040316020473000_","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"2023040316020473000_","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/ecco-jcc\/jjy154","article-title":"Natural disease course of ulcerative colitis during the first five years of follow-up in a European population-based inception cohort-an Epi-IBD study","volume":"13","author":"Burisch","year":"2019","journal-title":"J Crohns Colitis"},{"key":"2023040316020473000_"},{"key":"2023040316020473000_"},{"key":"2023040316020473000_","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3109\/00365528909091339","article-title":"Classification of inflammatory bowel disease","volume":"24","author":"Lennard-Jones","year":"1989","journal-title":"Scand J Gastroenterol"},{"key":"2023040316020473000_","first-page":"287","article-title":"Crohn\u2019s disease-occurrence, course and prognosis. An epidemiologic cohort-study","volume":"44","author":"Munkholm","year":"1997","journal-title":"Dan Med Bull"},{"key":"2023040316020473000_","doi-asserted-by":"crossref","first-page":"5A","DOI":"10.1155\/2005\/269076","article-title":"Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology","volume":"19","author":"Silverberg","year":"2005","journal-title":"Can J Gastroenterol"},{"key":"2023040316020473000_","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/j.crohns.2014.06.004","article-title":"EpiCom-group. Incidence and initial disease course of inflammatory bowel diseases in 2011 in Europe and Australia: results of the 2011 ECCO-EpiCom inception cohort","volume":"8","author":"Vegh","year":"2014","journal-title":"J Crohns Colitis"},{"key":"2023040316020473000_","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.cgh.2016.10.039","article-title":"Incidence and prevalence of Crohn\u2019s disease and ulcerative colitis in Olmsted County, Minnesota from 1970 through 2010","volume":"15","author":"Shivashankar","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2023040316020473000_","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1093\/jcag\/gwy054","article-title":"The impact of inflammatory bowel disease in Canada 2018: epidemiology","volume":"2","author":"Kaplan","year":"2019","journal-title":"J Can Assoc Gastroenterol"},{"key":"2023040316020473000_","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.dld.2016.07.012","article-title":"Nationwide prevalence and drug treatment practices of inflammatory bowel diseases in Hungary: a population-based study based on the National Health Insurance Fund database","volume":"48","author":"Kurti","year":"2016","journal-title":"Dig Liver Dis"},{"key":"2023040316020473000_","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.3109\/00365521.2014.962605","article-title":"Prevalence of inflammatory bowel disease: estimates for 2010 and trends in Germany from a large insurance-based regional cohort","volume":"49","author":"Hein","year":"2014","journal-title":"Scand J Gastroenterol"},{"key":"2023040316020473000_","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.cgh.2017.06.016","article-title":"Natural history of adult ulcerative colitis in population-based cohorts: a systematic review","volume":"16","author":"Fumery","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2023040316020473000_","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.dld.2018.04.011","article-title":"Impact of age at diagnosis on natural history of patients with elderly-onset ulcerative colitis: a French population-based study","volume":"50","author":"Duricova","year":"2018","journal-title":"Dig Liver Dis"},{"key":"2023040316020473000_","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1136\/gutjnl-2012-303864","article-title":"Natural history of elderly-onset inflammatory bowel disease: a population-based cohort study","volume":"63","author":"Charpentier","year":"2014","journal-title":"Gut"},{"key":"2023040316020473000_","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/ajg.2014.45","article-title":"Disease course and surgery rates in inflammatory bowel disease: a population-based, 7-year follow-up study in the era of immunomodulating therapy","volume":"109","author":"Vester-Andersen","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"2023040316020473000_","doi-asserted-by":"crossref","first-page":"848","DOI":"10.3109\/00365521.2016.1140807","article-title":"Association of extraintestinal manifestations and anaemia with disease outcomes in patients with inflammatory bowel disease","volume":"51","author":"Vegh","year":"2016","journal-title":"Scand J Gastroenterol"},{"key":"2023040316020473000_","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/ecco-jcc\/jjv099","article-title":"Treatment steps, surgery, and hospitalization rates during the first year of follow-up in patients with inflammatory bowel diseases from the 2011 ECCO-Epicom Inception Cohort","volume":"9","author":"Vegh","year":"2015","journal-title":"J Crohns Colitis"},{"key":"2023040316020473000_","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1093\/ecco-jcc\/jjaa232","article-title":"Outcome of ulcerative colitis 20 years after diagnosis in a prospective population-based inception cohort from South-Eastern Norway, the IBSEN Study","volume":"15","author":"Monstad","year":"2021","journal-title":"J Crohns Colitis"},{"key":"2023040316020473000_","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1038\/ajg.2012.333","article-title":"Decreasing colectomy rates for ulcerative colitis: a population-based time trend study","volume":"107","author":"Kaplan","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"2023040316020473000_","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1097\/MIB.0000000000000787","article-title":"Disease course and colectomy rate of ulcerative colitis: a follow-up cohort study of a referral Center in Tuscany","volume":"22","author":"Manetti","year":"2016","journal-title":"Inflamm Bowel Dis"}],"container-title":["Journal of Crohn's and Colitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/advance-article-pdf\/doi\/10.1093\/ecco-jcc\/jjac142\/46525565\/jjac142.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/17\/3\/352\/49732436\/jjac142.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/17\/3\/352\/49732436\/jjac142.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T03:28:24Z","timestamp":1701055704000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article\/17\/3\/352\/6705518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,19]]},"references-count":27,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,9,19]]},"published-print":{"date-parts":[[2023,4,3]]}},"URL":"https:\/\/doi.org\/10.1093\/ecco-jcc\/jjac142","relation":{},"ISSN":["1873-9946","1876-4479"],"issn-type":[{"value":"1873-9946","type":"print"},{"value":"1876-4479","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,3,1]]},"published":{"date-parts":[[2022,9,19]]}}}