{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:56:58Z","timestamp":1790776618345,"version":"4.1.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>The aim of this systematic review was to assess the literature on the incidence and risk factors for colorectal cancer and anal cancer in patients with perianal Crohn\u2019s disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A systematic review of the literature was performed using PubMed, Embase and Google Scholar. A meta-analysis was then conducted using a random-effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five studies were included in the systematic review. Of the total patients, 26.5% had perianal Crohn\u2019s disease. The median follow-up was 6 years. In total, 127 cases of colorectal cancer were found [0.43% of the included Crohn\u2019s disease patients]. Perianal involvement was present in 50% of colorectal cancer patients [0.89% of the population]. Three of the studies specified the cancer to be rectal or anal, which were present in 68 and 24 cases [0.3% and 0.1% of patients], respectively. In a subgroup analysis of rectal and anal cancer, perianal involvement was most frequent in anal cancer, accounting for 46% of the cases. In the rectal cancer group, 37% had perianal involvement. The higher incidence of colorectal cancer in patients with perianal Crohn\u2019s disease was confirmed in a meta-analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Half of the patients with colorectal cancer and anal cancer were found to have perianal Crohn\u2019s disease. In patients with perianal involvement, there was a higher percentage of anal cancer compared with rectal cancer. These results support the theory that patients with perianal Crohn\u2019s disease are at increased risk for developing colorectal and anal cancer. Studies collecting more detailed data regarding patients and their cancers are needed to further specify the disease course.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjac143","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T19:05:28Z","timestamp":1663787128000},"page":"361-368","source":"Crossref","is-referenced-by-count":23,"title":["Perianal Crohn\u2019s Disease and the Development of Colorectal and Anal Cancer: A Systematic Review and Meta-analysis"],"prefix":"10.1093","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9839-8843","authenticated-orcid":false,"given":"Martha Pollen","family":"Johansen","sequence":"first","affiliation":[{"name":"Abdominalcenter K, Surgical Division, Copenhagen University Hospital \u2013 Bispebjerg and Frederiksberg , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads Damsgaard","family":"Wewer","sequence":"additional","affiliation":[{"name":"Gastrounit, 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