{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:52:25Z","timestamp":1787165545938,"version":"build-2736575974"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003122","name":"Ferring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003122","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012276","name":"Tillotts Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012276","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Patients with longstanding inflammatory bowel disease [IBD] may be at an increased risk of death compared to the general population, especially elderly patients. The Inflammatory Bowel South-Eastern Norway [IBSEN] study has previously detected a small but not statistically significant increase in mortality 20 years after diagnosis. The aim of this study was to evaluate the overall and cause-specific mortality at 30 years of follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The IBSEN cohort included 519 incident patients with ulcerative colitis [UC] and 237 patients with Crohn\u2019s disease [CD] between 1990 and 1993, each matched with five controls. Death certificate data were obtained from the Norwegian Cause of Death Registry. The underlying causes of death were categorized into five groups: all cancers, gastrointestinal cancers, cardiovascular diseases, infections and all other causes. Hazard ratios [HRs] were modelled using Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was no statistically significant difference in the overall mortality rates. However, in patients with CD, male sex (HR = 1.65 [95% CI: 1.04\u20132.62]), onset after 40 years of age (HR = 1.72 [1.19\u20132.48]), colonic disease (HR = 1.57 [1.05\u20132.35]) and penetrating behaviour (HR = 3.3 [1.41\u20137.76]) were clinical factors associated with an increased mortality. IBD patients were at a higher risk of death due to cardiovascular disease: HR = 1.51 [1.10\u20132.08] for UC and 2.04 [1.11\u20133.77] for CD. When taking into account both the underlying and the immediate cause of death, infection was more frequent in patients with IBD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, all-cause mortality rates were similar between patients with IBD and controls. However, clinicians should remain alert to cardiovascular diseases and infections, particularly in specific subgroups of CD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjac156","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T16:37:43Z","timestamp":1665592663000},"page":"497-503","source":"Crossref","is-referenced-by-count":45,"title":["Mortality in Patients with Inflammatory Bowel Disease: Results from 30 Years of Follow-up in a Norwegian Inception Cohort (the IBSEN study)"],"prefix":"10.1093","volume":"17","author":[{"given":"Benoit","family":"Follin-Arbelet","sequence":"first","affiliation":[{"name":"Oslo University Hospital, Department of Gastroenterology , Oslo , Norway"},{"name":"University of Oslo, Institute of Clinical Medicine , Oslo , Norway"},{"name":"\u00d8stfold University College , Halden , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milada","family":"Cvancarova Sm\u00e5stuen","sequence":"additional","affiliation":[{"name":"Oslo University Hospital, Department of Gastroenterology , Oslo , Norway"},{"name":"Oslo Metropolitan University, Department of Public Health , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8istein","family":"Hovde","sequence":"additional","affiliation":[{"name":"University of Oslo, Institute of Clinical Medicine , Oslo , Norway"},{"name":"Innlandet Hospital Trust , Gj\u00f8vik , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars-Petter","family":"Jelsness-J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"\u00d8stfold University College , Halden , Norway"},{"name":"\u00d8stfold Hospital Trust , Halden , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn","family":"Moum","sequence":"additional","affiliation":[{"name":"Oslo University Hospital, Department of Gastroenterology , Oslo , Norway"},{"name":"University of 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