{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:32:30Z","timestamp":1740148350147,"version":"3.37.3"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>Post-inflammatory polyps [PIPs] are considered as indicators of previous episodes of severe inflammation and mucosal ulceration. Inflammatory bowel disease [IBD], namely Crohn\u2019s disease [CD] and ulcerative colitis [UC], exhibit a perpetuating, relapsing and remitting pattern, and PIPs are a frequent sequela of chronicity. The aim of this study was to determine whether a high PIP burden is associated with a more severe disease course in patients with IBD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a multinational, multicentre, retrospective study. IBD patients previously diagnosed with PIPs were retrieved from the endoscopic database of each centre. PIP burden was evaluated and associated with demographic and clinical data as well as factors indicating a more unfavourable disease course.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 504 IBD patients with PIPs were recruited [male: 61.9%]. The mean age at IBD diagnosis was 36.9 [\u00b116.8] years. Most patients [74.8%] were diagnosed with UC. A high PIP burden was present in 53.4% of patients. On multivariable Cox regression analysis, a high PIP burden was independently associated with treatment escalation (hazard ratio [HR] 1.35, 95% confidence interval [CI] 1.04\u20131.75; p\u2005=\u20050.024), hospitalization [HR 1.90; 95% CI 1.24\u20132.90; p\u2005=\u20050.003], need for surgery [HR 2.28; 95% CI 1.17\u20134.44, p\u2005=\u20050.02] and younger age at diagnosis [HR 0.99, 95% CI 0.98\u20130.99; p\u2005=\u20050.003].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>PIP burden was associated with a more severe outcome. Future prospective studies should focus on the characterization of PIP burden as to further risk stratify this patient cohort.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjac169","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T18:07:45Z","timestamp":1667412465000},"page":"489-496","source":"Crossref","is-referenced-by-count":1,"title":["Post-inflammatory Polyp Burden as a Prognostic Marker of Disease-outcome in Patients with Inflammatory Bowel Disease"],"prefix":"10.1093","volume":"17","author":[{"given":"Pierre","family":"Ellul","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Mater Dei hospital , Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Schembri","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Mater Dei hospital , Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Vella Baldacchino","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Mater Dei hospital , Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4913-7599","authenticated-orcid":false,"given":"Tamas","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Medicine, Szent-Gy\u00f6rgyi Albert Medical School, University of Szeged , Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamas","family":"Resal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Szent-Gy\u00f6rgyi Albert Medical School, University of Szeged , Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariangela","family":"Allocca","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy, IRCCS Hospital San Raffaele and University Vita-Salute San Raffaele , Milan , 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UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2226-0810","authenticated-orcid":false,"given":"Shellie","family":"Radford","sequence":"additional","affiliation":[{"name":"Nottingham University Hospitals NHS Trust , Nottingham , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8906-6908","authenticated-orcid":false,"given":"Gordon","family":"Moran","sequence":"additional","affiliation":[{"name":"Nottingham University Hospitals NHS Trust , Nottingham , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haidee","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Hull University Teaching Hospitals , Hull , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3670-6545","authenticated-orcid":false,"given":"Shaji","family":"Sebastian","sequence":"additional","affiliation":[{"name":"Hull University Teaching 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