{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:27:23Z","timestamp":1793212043834,"version":"4.5.0"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100002661","name":"National Fund for Scientific Research","doi-asserted-by":"publisher","award":["40001034"],"award-info":[{"award-number":["40001034"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aim<\/jats:title>\n                  <jats:p>In view of their frequent onset during childbearing years, the impact of inflammatory bowel diseases [IBD] on reproductive health is of important concern to young women and to the IBD physician. This study aims to assess the fertility and assisted reproductive technologies outcomes in non-surgically treated IBD females.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A systematic review was conducted using MEDLINE, SCOPUS, and EMBASE [until March 2022] to identify studies assessing fertility and assisted reproductive technologies outcomes in women with non-operated IBD, compared with non-IBD patients. Two reviewers independently selected studies, assessed risk of bias, and extracted study data.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 14 studies encompassing 18 012 patients with ulcerative colitis [UC] and 14 353 patients with Crohn\u2019s disease [CD] were included for analysis. The fertility rate in UC patients and in the general population was comparable, but UC patients tended to have fewer children, mainly by choice. On the contrary, the fertility of CD patients appeared to be reduced. Although a deliberate component cannot be not excluded, the disease itself could affect fertility. Disease activity was associated with reduced fertility in both UC and CD patients. In CD, the colonic involvement of the disease and perianal damage could be associated with subfertility, but data are less consistent. According to the only study reporting the assisted reproductive technologies outcomes, pregnancy rates after in vitro fertilization in subfertile non-operated UC patients and non-IBD patients were similar.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>There is low-quality evidence from observational studies that patients with CD and relapsing UC may have impaired fertility. After assisted reproductive technologies, pregnancy rates of subfertile non-operated UC patients were similar to those of the general population, although this observation requires further scrutiny in larger studies that should include UC and CD patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjac170","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T05:02:31Z","timestamp":1667278951000},"page":"614-632","source":"Crossref","is-referenced-by-count":14,"title":["Fertility and Assisted Reproductive Technologies Outcomes of Women with Non-surgically Managed Inflammatory Bowel Diseases: A Systematic Review"],"prefix":"10.1093","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1859-7146","authenticated-orcid":false,"given":"Sophie","family":"Vieujean","sequence":"first","affiliation":[{"name":"Hepato-Gastroenterology and Digestive Oncology, University Hospital CHU of Li\u00e8ge , Li\u00e8ge , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"De Vos","sequence":"additional","affiliation":[{"name":"Centre for Reproductive Medicine, UZ Brussel , Brussels , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Paridaens","sequence":"additional","affiliation":[{"name":"Ferring International Center S.A , Saint-Prex , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurang S","family":"Daftary","sequence":"additional","affiliation":[{"name":"Ferring Pharmaceuticals A\/S \u2013 International PharmaScience Center , Kastrup , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Danese","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Endoscopy, IRCCS San Raffaele and Vita-Salute San Raffaele University , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Peyrin-Biroulet","sequence":"additional","affiliation":[{"name":"University of Lorraine, CHRU-Nancy, Department of Gastroenterology , F-54000 Nancy , France"},{"name":"University of Lorraine, Inserm, NGERE , F-54000 Nancy , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"2023041916522907000_CIT0001","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/S0140-6736(16)31711-1","article-title":"Crohn\u2019s disease","volume":"389","author":"Torres","year":"2017","journal-title":"Lancet"},{"key":"2023041916522907000_CIT0002","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet"},{"key":"2023041916522907000_CIT0003","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1093\/jcag\/gwy054","article-title":"The Impact of inflammatory bowel disease in Canada 2018: Epidemiology","volume":"2","author":"Kaplan","year":"2019","journal-title":"J Can Assoc Gastroenterol"},{"key":"2023041916522907000_CIT0004","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1159\/000442929","article-title":"Psychological stress and depression: risk factors for IBD?","volume":"34","author":"Bernstein","year":"2016","journal-title":"Dig Dis"},{"key":"2023041916522907000_CIT0005","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.fertnstert.2016.09.029","article-title":"Optimizing natural fertility: a committee opinion.","volume":"107","year":"2017","journal-title":"Fertil Steril"},{"key":"2023041916522907000_CIT0006","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1002\/art.30327","article-title":"Time to pregnancy among women with rheumatoid arthritis","volume":"63","author":"Jawaheer","year":"2011","journal-title":"Arthritis Rheum"},{"key":"2023041916522907000_CIT0007","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.cgh.2015.03.016","article-title":"In vitro fertilization in women with inflammatory bowel disease is as successful as in women from the general infertility population","volume":"13","author":"Oza","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2023041916522907000_CIT0008","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/ajg.2014.400","article-title":"In vitro fertilization is successful in women with ulcerative colitis and ileal pouch anal anastomosis","volume":"110","author":"Pabby","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"2023041916522907000_CIT0009","article-title":"European Crohn\u2019s and Colitis Guidelines on Sexuality, Fertility, Pregnancy, and Lactation","author":"Torres","year":"2022","journal-title":"J Crohns Colitis"},{"key":"2023041916522907000_CIT0010","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1136\/gut.2005.090316","article-title":"Higgins PDR. 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