{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T23:14:12Z","timestamp":1784848452301,"version":"3.55.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100007028","name":"Leona M. and Harry B. Helmsley Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Given the paucity of population-based data on the association between inflammatory bowel diseases [IBD], coeliac disease [CeD], and coeliac autoimmunity [CeA] we aimed to study the associations in a nationwide study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using health administrative data for all four health maintenance organisations in Israel, covering 98% of the population, we explored the prevalence of CeD in children and adults with IBD versus non-IBD matched controls. CeD was defined by three ICD-9 codes and CeA by positivity for tissue transglutaminase antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 34 375 IBD patients (56% Crohn\u2019s disease [CD] and 44% ulcerative colitis [UC]) were compared with 93 603 non-IBD controls. Among IBD patients, 319 [0.93%] had CeD versus 294 [0.31%] non-IBD controls (odds ratio [OR]\u2005=\u20052.97, 95% confidence interval [CI] 2.54-3.48; p\u2005&amp;lt;0.001). CeA was identified in 575 [1.67%] IBD patients vs 158 [0.17%] controls [OR\u2005=\u200510.06, 95% CI 8.43-12; p\u2005&amp;lt;0.001]. The prevalence of CeD was higher in paediatric-onset IBD (87\/5243 [1.66%]) than adult-onset IBD (232\/29 132 [0.79%]; p\u2005&amp;lt;0.001). CD patients had a higher prevalence of CeD (229\/19 264 [1.19%]) than UC patients (90\/15 111 [0.56%]; OR\u2005=\u20052.01, 95% CI 1.57-2.56; p\u2005&amp;lt;0.001). The diagnosis of CeD preceded the diagnosis of IBD in 241\/319 cases [76%]. The time to treatment escalation was shorter in patients with both IBD and CeD than in patients with IBD without CeD [p\u2005=\u20050.017].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CeD and CeA are more prevalent in IBD patients, especially in paediatric-onset IBD and in CD. The diagnosis of CeD usually precedes that of IBD. Having CeD is associated with more intensified treatment for IBD.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjac176","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T22:00:56Z","timestamp":1668549656000},"page":"700-705","source":"Crossref","is-referenced-by-count":10,"title":["The Association of Inflammatory Bowel Disease with Coeliac Disease and Coeliac Autoimmunity in Children and Adults: A Nationwide Study from the epi-IIRN"],"prefix":"10.1093","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5519-8259","authenticated-orcid":false,"given":"Michal","family":"Kori","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology, Kaplan Medical Center , Rehovot , Israel"},{"name":"Faculty of Medicine, Hebrew University of Jerusalem , Jerusalem , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonatan","family":"Zamir","sequence":"additional","affiliation":[{"name":"Department of Industrial Engineering & Management, Azrieli College of Engineering Jerusalem , Jerusalem , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami Or","family":"Yermiyahu","sequence":"additional","affiliation":[{"name":"Department of Industrial Engineering & Management, Azrieli College of Engineering Jerusalem , Jerusalem , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inessa","family":"Ainbinder","sequence":"additional","affiliation":[{"name":"Department of Industrial Engineering & Management, Azrieli College of Engineering Jerusalem , Jerusalem , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Daichman","sequence":"additional","affiliation":[{"name":"Sami Shamoon College of Engineering , Beer Sheva , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavriel David","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Industrial Engineering & Management, Azrieli College of Engineering Jerusalem , Jerusalem , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiska","family":"Loewenberg Weisband","sequence":"additional","affiliation":[{"name":"Clalit Health Services, Clalit Research Institute , Tel-Aviv , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shira","family":"Greenfeld","sequence":"additional","affiliation":[{"name":"Clalit Health Services, Clalit Research Institute , Tel-Aviv , Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University , Israel"},{"name":"Maccabi Health Services , Tel-Aviv , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Revital","family":"Kariv","sequence":"additional","affiliation":[{"name":"Meuhedet Health Services , Tel-Aviv , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natan","family":"Lederman","sequence":"additional","affiliation":[{"name":"Leumit Health Services , Tel-Aviv , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eran","family":"Matz","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Rabin Medical Center , Petah Tikva , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raanan","family":"Shamir","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children\u2019s Medical Center of Israel , Petach Tikva , Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Dotan","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel Aviv University , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Turner","sequence":"additional","affiliation":[{"name":"Juliet Keidan Institute of Pediatric Gastroenterology, Hebrew University of Jerusalem , Jerusalem , 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