{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T07:31:20Z","timestamp":1793431880989,"version":"4.5.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Multiple chronic ulcers of small intestine are mainly ascribed to Crohn\u2019s disease. Among possible differential diagnoses are chronic ulcers of small bowel caused by abnormal activation of the prostaglandin pathway either in the archetypal but uncommon non-steroidal anti-inflammatory drug [NSAID]-induced enteropathy, or in rare monogenic disorders due to PLA2G4A and SLCO2A1 mutations. SLCO2A1 variants are responsible for CEAS [chronic enteropathy associated with SLCO2A1], a syndrome which was exclusively reported in patients of Asian origin. Herein, we report the case of two French female siblings, P1 and P2, with CEAS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case report<\/jats:title>\n                  <jats:p>P1 underwent iterative bowel resections [removing 1 m of small bowel in total] for recurrent strictures and perforations. Her sister P2 had a tight duodenal stricture which required partial duodenectomy. Next-generation sequencing was performed on P1\u2019s DNA and identified two compound heterozygous variants in exon 12 in SLCO2A1, which were also present in P2.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>CEAS can be detected within the European population and raises the question of its incidence and recognition outside Asia. Presence of intractable recurrent ulcerations of the small intestine, mimicking Crohn\u2019s disease with concentric strictures, should motivate a genetic search for SLCO2A1 mutations, particularly in the context of family history or consanguinity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjac181","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T07:43:30Z","timestamp":1670399010000},"page":"816-820","source":"Crossref","is-referenced-by-count":18,"title":["Crohn-like Disease Affecting Small Bowel Due to Monogenic <i>SLCO2A1<\/i> Mutations: First Cases of Chronic Enteropathy Associated with <i>SLCO2A1<\/i> Gene [CEAS] in France"],"prefix":"10.1093","volume":"17","author":[{"given":"Annick","family":"Hamon","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Beaujon Hospital, University of Paris , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Cazals-Hatem","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beaujon Hospital, University of Paris , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Stefanescu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Beaujon Hospital, University of Paris , Paris , France"},{"name":"Groupe Hospitalier Ambroise Par\u00e9 \u2013 Hartmann, Institut des MICI , Neuilly sur Seine , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Uzzan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Mondor Hospital, University of Paris , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Treton","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Beaujon Hospital, University of Paris , Paris , France"},{"name":"Groupe Hospitalier Ambroise Par\u00e9 \u2013 Hartmann, Institut des MICI , Neuilly sur Seine , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Sauvanet","sequence":"additional","affiliation":[{"name":"Department of Hepato-biliary Surgery, Beaujon Hospital, University of Paris , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9553-9727","authenticated-orcid":false,"given":"Yves","family":"Panis","sequence":"additional","affiliation":[{"name":"Department of Hepato-biliary Surgery, Beaujon Hospital, University of Paris , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Monsinjon","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Beaujon Hospital , Paris , 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