{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:25:59Z","timestamp":1773296759945,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>Faecal incontinence is an important complaint reported by patients with Crohn\u2019s disease [CD] and it is associated with several disease-related mechanisms, including anorectal functional disorders. This study aimed to assess the anorectal function and clinical characteristics to identify parameters associated with faecal incontinence in CD patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This is a cross-sectional study of 104 patients with CD, aged 18 years or older, from a referral centre between August 2019 and May 2021. Patients responded to a specific questionnaire, and underwent medical record review, proctological examination and anorectal functional assessment with anorectal manometry.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 104 patients, 49% were incontinent. Patients with incontinence had a lower mean resting pressure [43.5 vs 53.1 mmHg; p\u2005=\u20050.038], lower mean squeeze pressure [62.1 vs 94.1 mmHg; p\u2005=\u20050.036] and lower maximum rectal capacity [140 vs 180 mL; p\u2005&amp;lt;\u20050.001]. Faecal incontinence was also associated with disease activity [p\u2005&amp;lt;\u20050.001], loose stools [p\u2005=\u20050.02], perianal disease [p\u2005=\u20050.006], previous anoperineal surgery [p\u2005=\u20050.048] and number of anorectal surgeries [p\u2005=\u20050.036].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This is the largest reported study describing manometric findings of Crohn\u2019s disease patients with and without faecal incontinence. Our results identified an association between faecal incontinence and functional disorders, in addition to clinical features in these patients. Functional assessment with anorectal manometry may help choose the best treatment for faecal incontinence in patients with CD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjad048","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T15:34:05Z","timestamp":1679585645000},"page":"1252-1261","source":"Crossref","is-referenced-by-count":8,"title":["Anorectal Function and Clinical Characteristics Associated with Faecal Incontinence in Patients with Crohn\u2019s Disease"],"prefix":"10.1093","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0303-9926","authenticated-orcid":false,"given":"Lina Maria G\u00f3es","family":"de Codes","sequence":"first","affiliation":[{"name":"Medicine and Health Science Postgraduate Program, Universidade Federal da Bahia, Salvador, Brazil; Department of Surgery, Hospital Universit\u00e1rio Professor Edgard Santos , Salvador , 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