{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:34:57Z","timestamp":1792096497892,"version":"4.4.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Intestinal ultrasound [IUS] is widely accepted as a reliable tool to monitor Crohn\u2019s disease [CD]. Several IUS scores have been proposed, but none has been formally accepted by international organizations. Our aim here was to compare the available scores regarding their correlation with endoscopic activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consenting CD patients undergoing ileocolonoscopy at our Unit between September 2021 and February 2023 were included. Endoscopic activity was defined as SES-CD\u2005\u2265\u20053 or Rutgeerts score\u2005\u2265\u2005i2b for operated patients. IUS was performed within 6 weeks of endoscopy and scored with IBUS-SAS, BUSS, Simple-US and SUS-CD scores. All correlations were performed using Spearman\u2019s rank coefficient [rho = \u03c1]. Receiver operating characteristic [ROC] curves were compared with the Hanley and McNeil method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 73 CD patients, 45 [61.6%] presented endoscopic activity, of whom 22 were severe [30.1%]. All IUS scores showed a significant positive correlation with endoscopy [p\u2005&amp;lt;\u20050.0001], with IBUS-SAS ranking the highest [\u03c1\u2005=\u20050.87]. Similarly, IBUS-SAS was the most highly correlated with clinical activity [\u03c1\u2005=\u20050.58]. ROC analysis of IBUS-SAS for any endoscopic activity showed the highest area under the curve (0.95 [95% confidence interval 0.87\u20130.99]), with sensitivity of 82.2% and specificity of 100% for a cut-off value of 25.2. IBUS-SAS was statistically superior to all the other scores in detecting severe endoscopic activity [SES-CD\u2005\u2265\u20059 or Rutgeerts i4].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>All IUS scores provided solid correlation with endoscopy and clinical symptoms. IBUS-SAS outperformed the others due to a more granular description that might help in stratifying different levels of disease activity. Therefore, the use of IBUS-SAS in centres with well-founded expertise in IUS can be suggested.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjad068","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T13:25:21Z","timestamp":1680787521000},"page":"1387-1394","source":"Crossref","is-referenced-by-count":63,"title":["Correlation of Ultrasound Scores with Endoscopic Activity in Crohn\u2019s Disease: A Prospective Exploratory Study"],"prefix":"10.1093","volume":"17","author":[{"given":"Gabriele","family":"Dragoni","sequence":"first","affiliation":[{"name":"Gastroenterology Research Unit, Department of Experimental and Clinical Biomedical Sciences \u2018Mario Serio\u2019, University of Florence , Florence , Italy"},{"name":"IBD Referral Centre, Azienda Ospedaliero-Universitaria Careggi , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Gottin","sequence":"additional","affiliation":[{"name":"Gastroenterology Research Unit, Department of Experimental and Clinical Biomedical Sciences \u2018Mario Serio\u2019, University of Florence , Florence , Italy"},{"name":"IBD Referral Centre, Azienda Ospedaliero-Universitaria Careggi , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Innocenti","sequence":"additional","affiliation":[{"name":"Gastroenterology Research Unit, Department of Experimental and Clinical Biomedical Sciences \u2018Mario Serio\u2019, University of Florence , Florence , Italy"},{"name":"IBD Referral Centre, Azienda Ospedaliero-Universitaria Careggi , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica Nicola","family":"Lynch","sequence":"additional","affiliation":[{"name":"Gastroenterology Research Unit, Department of Experimental and Clinical Biomedical Sciences \u2018Mario Serio\u2019, University of Florence , Florence , Italy"},{"name":"IBD Referral Centre, Azienda Ospedaliero-Universitaria Careggi , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siro","family":"Bagnoli","sequence":"additional","affiliation":[{"name":"IBD Referral Centre, Azienda Ospedaliero-Universitaria Careggi , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Macr\u00ec","sequence":"additional","affiliation":[{"name":"IBD Referral Centre, Azienda Ospedaliero-Universitaria Careggi , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Giovanni","family":"Bonanomi","sequence":"additional","affiliation":[{"name":"IBD Referral Centre, Azienda Ospedaliero-Universitaria Careggi , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Orlandini","sequence":"additional","affiliation":[{"name":"IBD Referral Centre, Azienda Ospedaliero-Universitaria Careggi , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Rogai","sequence":"additional","affiliation":[{"name":"IBD Referral Centre, Azienda Ospedaliero-Universitaria Careggi , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Milani","sequence":"additional","affiliation":[{"name":"Gastroenterology Research Unit, Department of Experimental and Clinical Biomedical Sciences \u2018Mario Serio\u2019, University of Florence , Florence , Italy"},{"name":"IBD Referral Centre, Azienda Ospedaliero-Universitaria Careggi , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Galli","sequence":"additional","affiliation":[{"name":"Gastroenterology Research Unit, Department of Experimental and Clinical Biomedical Sciences \u2018Mario Serio\u2019, University of Florence , Florence , Italy"},{"name":"IBD Referral Centre, Azienda Ospedaliero-Universitaria Careggi , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Milla","sequence":"additional","affiliation":[{"name":"IBD Referral Centre, Azienda Ospedaliero-Universitaria Careggi , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosa","family":"Biagini","sequence":"additional","affiliation":[{"name":"Gastroenterology Research Unit, Department of Experimental and Clinical Biomedical Sciences \u2018Mario Serio\u2019, University of Florence , Florence , Italy"},{"name":"IBD Referral Centre, Azienda Ospedaliero-Universitaria Careggi , 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