{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:27:42Z","timestamp":1793212062058,"version":"4.5.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Accurate tools to distinguish Crohn\u2019s disease [CD] from cryptoglandular disease in patients with perianal fistulas without detectable luminal inflammation on ileocolonoscopy and abdominal enterography (isolated perianal fistulas [IPF]) are lacking. We assessed the ability of video capsule endoscopy [VCE] to detect luminal inflammation in patients with IPF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We studied consecutive adults [&amp;gt;17 years] with IPF who were evaluated by VCE after a negative ileocolonoscopy and abdominal enterography between 2013 and 2022. We defined luminal CD by VCE as diffuse erythema, three or more aphthous ulcers, or a Lewis score greater than 135. We compared rates of intestinal inflammation in this cohort with age- and sex-matched controls without perianal fistulas, who underwent VCE for other indications. We excluded persons with pre-existing inflammatory bowel disease [IBD] and exposure to non-steroidal anti-inflammatory drugs or immunosuppressive treatments.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 45 patients with IPF underwent VCE without complications. Twelve patients [26%] met our definition of luminal CD. Luminal CD was more common in patients with IPF than in controls [26% vs 3%; p\u2005&amp;lt;0.01]. Among patients with IPF, male sex (OR [odds ratio], 9.2; 95% confidence interval [CI] [1.1-79.4]), smoking (OR, 4.5; 95% CI [0.9-21.2]), abscess (OR, 6.3; 95% CI [1.5-26.8]), rectal enhancement on magnetic resonance imaging [MRI] (OR, 9.0; 95% CI [0.8-99.3]), and positive antimicrobial serology (OR, 7.1; 95% CI, [0.7-70.0]) were more common in those with a positive VCE study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>VCE detected small intestinal inflammation suggestive of luminal CD in approximately one-quarter of patients with IPF. Larger studies are required to validate these findings.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjad078","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T04:41:53Z","timestamp":1682570513000},"page":"1624-1630","source":"Crossref","is-referenced-by-count":12,"title":["Video Capsule Endoscopy can Identify Occult Luminal Crohn\u2019s Disease in Patients with Isolated Perianal Fistulas"],"prefix":"10.1093","volume":"17","author":[{"given":"Jeffrey D","family":"McCurdy","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Ottawa , Ottawa, ON , Canada"},{"name":"Ottawa Hospital Research Institute , Ottawa, ON , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ottawa , Ottawa, ON , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Parlow","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ottawa , Ottawa, ON , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne M","family":"Dawkins","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ottawa , Ottawa, ON , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurmun","family":"Brar","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ottawa , Ottawa, ON , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ottawa , Ottawa, ON , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nav","family":"Saloojee","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ottawa , Ottawa, ON , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Murthy","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ottawa , Ottawa, ON , Canada"},{"name":"Ottawa Hospital Research Institute , Ottawa, ON , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Kenshil","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ottawa , Ottawa, ON , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blair","family":"Macdonald","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute , Ottawa, ON , Canada"},{"name":"Department of Medical Imaging, University of Ottawa , Ottawa, ON , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Sabri","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute , Ottawa, ON , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Husein","family":"Moloo","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute , Ottawa, ON , Canada"},{"name":"Department of Surgery, University of Ottawa , Ottawa, ON , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9085-6085","authenticated-orcid":false,"given":"Richmond","family":"Sy","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ottawa , Ottawa, ON , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"key":"2023111012334219100_CIT0001","doi-asserted-by":"crossref","first-page":"300060520986669","DOI":"10.1177\/0300060520986669","article-title":"Current concepts in the pathogenesis of cryptoglandular perianal fistula","volume":"49","author":"W\u0142odarczyk","year":"2021","journal-title":"J Int Med 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