{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:53:20Z","timestamp":1762300400189,"version":"3.37.3"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>Intestinal failure [IF] is a recognised complication of Crohn\u2019s disease [CD]. The aim of this study was to identify factors predicting the development and recurrence of CD in patients with IF [CD-IF], and their long-term outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a cohort study of adults with CD-IF admitted to a national UK IF reference centre between 2000 and 2021. Patients were followed from discharge with home parenteral nutrition [HPN] until death or February 28, 2021.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In all, 124 patients were included; 47 [37.9%] changed disease location and 55 [44.4%] changed disease behaviour between CD and CD-IF diagnosis, with increased upper gastrointestinal involvement [4.0% vs 22.6% patients], p\u2005&amp;lt;0.001. Following IF diagnosis, 29\/124 [23.4%] patients commenced CD prophylactic medical therapy; 18 [62.1%] had a history of stricturing or penetrating small bowel disease; and nine [31.0%] had ileocolonic phenotype brought back into continuity. The cumulative incidence of disease recurrence was 2.4% at 1 year, 16.3% at 5 years and 27.2% at 10 years; colon-in-continuity and prophylactic treatment were associated with an increased likelihood of disease recurrence. Catheter-related bloodstream infection [CRBSI] rate was 0.32 episodes\/1000 catheter days, with no association between medical therapy and CRBSI rate.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This is the largest series reporting disease behaviour and long-term outcomes in CD-IF and the first describing prophylactic therapy use. The incidence of disease recurrence was low. Immunosuppressive therapy appears to be safe in HPN-dependent patients with no increased risk of CRBSI. The management of CD-IF needs to be tailored to the patient\u2019s surgical disease history alongside disease phenotype.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjad105","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T18:56:36Z","timestamp":1688410596000},"page":"1910-1919","source":"Crossref","is-referenced-by-count":5,"title":["Disease Recurrence and Long-term Outcomes Following the Development of Intestinal Failure in Crohn\u2019s Disease: Over 20 Years of Experience from a National Reference Centre"],"prefix":"10.1093","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3448-9476","authenticated-orcid":false,"given":"Maja","family":"Kopczynska","sequence":"first","affiliation":[{"name":"Intestinal Failure Unit, Salford Royal NHS Foundation Trust , Salford , UK"},{"name":"School of Health Sciences, University of Manchester , Manchester , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Crooks","sequence":"additional","affiliation":[{"name":"Intestinal Failure Unit, Salford Royal NHS Foundation Trust , Salford , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liat","family":"Deutsch","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Liver Disease, Tel Aviv Sourasky Medical Centre, Tel Aviv University , Tel Aviv , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Conley","sequence":"additional","affiliation":[{"name":"Intestinal Failure Unit, Salford Royal NHS Foundation Trust , Salford , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Stansfield","sequence":"additional","affiliation":[{"name":"Intestinal Failure Unit, Salford Royal NHS Foundation Trust , Salford , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Bond","sequence":"additional","affiliation":[{"name":"Intestinal Failure Unit, Salford Royal NHS Foundation Trust , Salford , UK"},{"name":"School of Health Sciences, University of Manchester , Manchester , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4287-6978","authenticated-orcid":false,"given":"Mattias","family":"Soop","sequence":"additional","affiliation":[{"name":"Intestinal Failure Unit, Salford Royal NHS Foundation Trust , Salford , UK"},{"name":"Department of Inflammatory Bowel Disease and Intestinal Failure Surgery, Karolinska University Hospital , Stockholm , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon","family":"Carlson","sequence":"additional","affiliation":[{"name":"Intestinal Failure Unit, Salford Royal NHS Foundation Trust , Salford , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Lal","sequence":"additional","affiliation":[{"name":"Intestinal Failure Unit, Salford Royal NHS Foundation Trust , Salford , UK"},{"name":"School of Health Sciences, University of Manchester , Manchester , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"2024012001504995400_CIT0001","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1093\/ecco-jcc\/jjaa060","article-title":"Causes and prognosis of intestinal failure in Crohn\u2019s disease: an 18-year experience from a national centre","volume":"14","author":"Soop","year":"2020","journal-title":"J Crohns Colitis"},{"key":"2024012001504995400_CIT0002","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00535-013-0797-y","article-title":"Long-term incidence and characteristics of intestinal failure in Crohn\u2019s disease: a multicenter study","volume":"49","author":"Watanabe","year":"2014","journal-title":"J Gastroenterol"},{"key":"2024012001504995400_CIT0003","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.clnu.2014.08.017","article-title":"ESPEN endorsed recommendations. 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