{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T21:27:48Z","timestamp":1769549268702,"version":"3.49.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Japan Sciences Research Grant for Research on Intractable Diseases"},{"name":"Japan Ministry of Health, Labour and Welfare","award":["17933520"],"award-info":[{"award-number":["17933520"]}]},{"name":"Japan Ministry of Health, Labour and Welfare","award":["20316729"],"award-info":[{"award-number":["20316729"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>Many patients have endoscopic evidence of recurrent Crohn\u2019s disease [CD] at 1 year after intestinal resection. These lesions predict future clinical recurrence. We endoscopically evaluated postoperative anastomotic lesions in CD patients from a large cohort of postoperative CD patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrospectively enrolled CD patients who underwent surgical resection between 2008 and 2013 at 19 inflammatory bowel disease [IBD]-specialist institutions. The initial analyses included patients who underwent ileocolonoscopy ~1 year after intestinal resection. Follow-up analyses assessed any changes in the endoscopic findings over time. We evaluated the postoperative endoscopic findings, which were classified into four categories [no lesion, mild, intermediate, severe] at the sites of the anastomotic line and peri-anastomosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 267 CD patients underwent postoperative ileocolonoscopy. Postoperative anastomotic lesions were widely detected in index ileocolonoscopy [61.0%] and were more frequently detected in follow-up ileocolonoscopy [74.9%]. Endoscopic severity also increased. Patients with intermediate or severe peri-anastomotic or anastomotic line lesions at the index ileocolonoscopy required significantly more interventions, including endoscopic dilatation or surgery, than patients with mild lesions or no lesions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Frequent anastomotic lesions were observed at the postoperative index ileocolonoscopy. These gradually increased for subsequent ileocolonoscopy, even in the biologic era. Regarding lesions on the anastomotic line, intermediate lesions on the anastomotic line [e.g. irregular or deep ulcers] might be considered recurrent disease, and mild lesions [e.g. linear superficial ulcers] might be considered non-recurrent disease. Prospective studies are needed to resolve this issue, including treatment enhancement.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjad116","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T20:56:41Z","timestamp":1689368201000},"page":"1968-1979","source":"Crossref","is-referenced-by-count":8,"title":["Endoscopic Lesions of Postoperative Anastomotic Area in Patients With Crohn\u2019s Disease in the Biologic Era: A Japanese Multi-Centre Nationwide Cohort Study"],"prefix":"10.1093","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4262-9937","authenticated-orcid":false,"given":"Takeshi","family":"Ueda","sequence":"first","affiliation":[{"name":"Department of Surgery, Nara Medical University , Kashihara , Japan"},{"name":"Sai Gastroenterology and Proctology Clinic , Fujiidera , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumikazu","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Surgery, Nara Medical University , Kashihara , Japan"},{"name":"Division of Endoscopy, Nara Medical University Hospital , Kashihara , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Sugita","sequence":"additional","affiliation":[{"name":"Department of Inflammatory Bowel Disease, Yokohama Municipal Citizen\u2019s Hospital , Yokohama , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Ikeuchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Division of Inflammatory Bowel Disease Surgery, Hyogo Medical University , Nishinomiya , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kitaro","family":"Futami","sequence":"additional","affiliation":[{"name":"Department of Surgery, Fukuoka University Chikushi Hospital , Chikusino , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouhei","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Ooizumi Memorial Hospital , Shiroishi , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4489-4272","authenticated-orcid":false,"given":"Riichiro","family":"Nezu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Osaka Central Hospital , Osaka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Iijima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, and Department of Gastroenterology, Department of Gastroenterology, Osaka Police Hospital , Osaka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0825-6823","authenticated-orcid":false,"given":"Tsunekazu","family":"Mizushima","sequence":"additional","affiliation":[{"name":"Department of Therapeutics for Inflammatory Bowel Diseases, Osaka University Graduate School of Medicine , Osaka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2664-1984","authenticated-orcid":false,"given":"Michio","family":"Itabashi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Gastroenterology, Tokyo Women\u2019s Medical University , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tohoku University Graduate School of Medicine , Sendai , 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kento","family":"Takenaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Aichi Medical University School of Medicine , Nagakute , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Nagayama","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Jichi Medical University , Shimotsuke , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Jichi Medical University , Shimotsuke , 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Medicine, Chiba University , Chiba , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Endoscopy and Medicine, Hiroshima University Hospital , Hiroshima , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Endoscopy and Medicine, Hiroshima University Hospital , Hiroshima , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8040-4854","authenticated-orcid":false,"given":"Yoshiki","family":"Okita","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine , Tsu , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinari","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Center for Gastroenterology, Junshin Hospital , Kakogawa , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2073-4234","authenticated-orcid":false,"given":"Taku","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutaka","family":"Koganei","sequence":"additional","affiliation":[{"name":"Department of Inflammatory Bowel Disease, Yokohama Municipal Citizen\u2019s Hospital , Yokohama , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2934-1680","authenticated-orcid":false,"given":"Motoi","family":"Uchino","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Division of Inflammatory Bowel Disease Surgery, Hyogo Medical University , Nishinomiya , 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