{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:18:03Z","timestamp":1787008683301,"version":"build-2736575974"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR 241"],"award-info":[{"award-number":["TRR 241"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["375876048"],"award-info":[{"award-number":["375876048"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Pain is a cardinal symptom in inflammatory bowel disease [IBD]. An important structure in the transduction of pain signalling is the myenteric plexus [MP]. Nevertheless, IBD-associated infiltration of the MP by immune cells lacks in-depth characterisation. Herein, we decipher intra- and periganglionic immune cell infiltrations in Crohn\u00b4s disease [CD] and ulcerative colitis [UC] and provide a comparison with murine models of colitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Full wall specimens of surgical colon resections served to examine immune cell populations by either conventional immuno-histochemistry or immunofluorescence followed by either bright field or confocal microscopy. Results were compared with equivalent examinations in various murine models of intestinal inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Whereas the MP morphology was not significantly altered in IBD, we identified intraganglionic IBD-specific B cell- and monocyte-dominant cell infiltrations in CD. In contrast, UC-MPs were infiltrated by CD8+ T cells and revealed a higher extent of ganglionic cell apoptosis. With regard to the murine models of intestinal inflammation, the chronic dextran sulphate sodium [DSS]-induced colitis model reflected CD [and to a lesser extent UC] best, as it also showed increased monocytic infiltration as well as a modest B cell and CD8+ T cell infiltration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In CD, MPs were infiltrated by B cells and monocytes. In UC, mostly CD8+ cytotoxic T cells were found. The chronic DSS-induced colitis in the mouse model reflected best the MP-immune cell infiltrations representative for IBD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjad122","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T16:45:19Z","timestamp":1691685919000},"page":"121-133","source":"Crossref","is-referenced-by-count":26,"title":["Myenteric Plexus Immune Cell Infiltrations and Neurotransmitter Expression in Crohn\u2019s Disease and Ulcerative Colitis"],"prefix":"10.1093","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6816-0014","authenticated-orcid":false,"given":"Jakob J","family":"Wiese","sequence":"first","affiliation":[{"name":"Medizinische Klinik m. S. Gastroenterologie, Infektiologie und Rheumatologie, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhakankha","family":"Manna","sequence":"additional","affiliation":[{"name":"Medizinische Klinik m. S. Gastroenterologie, Infektiologie und Rheumatologie, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja A","family":"K\u00fchl","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, iPATH.Berlin , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Fasc\u00ec","sequence":"additional","affiliation":[{"name":"Medizinische Klinik m. S. Gastroenterologie, Infektiologie und Rheumatologie, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sefer","family":"Elezkurtaj","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Sonnenberg","sequence":"additional","affiliation":[{"name":"Medizinische Klinik m. S. Gastroenterologie, Infektiologie und Rheumatologie, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin","family":"Bubeck","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Erlangen, Faculty of Medicine , Erlangen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja","family":"Atreya","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Erlangen, Faculty of Medicine , Erlangen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Erlangen, Faculty of Medicine , Erlangen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Weixler","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein- und Viszeralchirurgie, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, Berlin Institute of Health , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0055-958X","authenticated-orcid":false,"given":"Britta","family":"Siegmund","sequence":"additional","affiliation":[{"name":"Medizinische Klinik m. S. Gastroenterologie, Infektiologie und Rheumatologie, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay V","family":"Patankar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Erlangen, Faculty of Medicine , Erlangen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4522-7482","authenticated-orcid":false,"given":"Magdalena S","family":"Pr\u00fc\u00df","sequence":"additional","affiliation":[{"name":"Medizinische Klinik m. S. Gastroenterologie, Infektiologie und Rheumatologie, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Berlin , Germany"},{"name":"Berlin Institute of Health at Charit\u00e9 \u2013 Universit\u00e4tsmedizin, \u2013 Berlin, BIH Biomedical Innovation Academy, BIH, Charit\u00e9 Clinician Scientist Program , 10178 Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schumann","sequence":"additional","affiliation":[{"name":"Medizinische Klinik m. S. Gastroenterologie, Infektiologie und Rheumatologie, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Berlin , Germany"},{"name":"Berlin Institute of Health at Charit\u00e9 \u2013 Universit\u00e4tsmedizin, \u2013 Berlin, BIH Biomedical Innovation Academy, BIH, Charit\u00e9 Clinician Scientist Program , 10178 Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,11]]},"reference":[{"key":"2024012713305799200_CIT0001","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jcmgh.2017.03.007","article-title":"Mend your fences: The epithelial barrier and its relationship with mucosal immunity in inflammatory bowel disease","volume":"4","author":"Martini","year":"2017","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"2024012713305799200_CIT0002","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1056\/NEJMra2002697","article-title":"Pathophysiology of inflammatory bowel diseases","volume":"383","author":"Chang","year":"2020","journal-title":"N Engl J Med"},{"key":"2024012713305799200_CIT0003","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1097\/MIB.0000000000000170","article-title":"Pain management in patients with inflammatory bowel disease: Translational approaches from bench to bedside","volume":"20","author":"Srinath","year":"2014","journal-title":"Inflamm Bowel Dis"},{"key":"2024012713305799200_CIT0004","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/nrgastro.2012.32","article-title":"The enteric nervous system and neurogastroenterology","volume":"9","author":"Furness","year":"2012","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2024012713305799200_CIT0005","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.immuni.2017.05.011","article-title":"The enteric network: Interactions between the immune and nervous systems of the gut","volume":"46","author":"Yoo","year":"2017","journal-title":"Immunity"},{"key":"2024012713305799200_CIT0006","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1053\/j.gastro.2019.04.034","article-title":"Extrinsic primary afferent neurons link visceral pain to colon motility through a spinal reflex in mice","volume":"157","author":"Smith-Edwards","year":"2019","journal-title":"Gastroenterology"},{"key":"2024012713305799200_CIT0007","doi-asserted-by":"crossref","first-page":"G1056","DOI":"10.1152\/ajpgi.00319.2016","article-title":"Spinal afferent nerve endings in visceral organs: Recent advances","volume":"311","author":"Spencer","year":"2016","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2024012713305799200_CIT0008","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nature08652","article-title":"High-performance genetically targetable optical neural silencing by light-driven proton pumps","volume":"463","author":"Chow","year":"2010","journal-title":"Nature"},{"key":"2024012713305799200_CIT0009","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1097\/j.pain.0000000000002110","article-title":"Optogenetic inhibition of the colon epithelium reduces hypersensitivity in a mouse model of inflammatory bowel disease","volume":"162","author":"Najjar","year":"2021","journal-title":"Pain"},{"key":"2024012713305799200_CIT0010","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/0304-3940(91)90484-B","article-title":"Identification of myenteric neurons which project to the mucosa of the guinea-pig small intestine","volume":"129","author":"Song","year":"1991","journal-title":"Neurosci Lett"},{"key":"2024012713305799200_CIT0011","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrgastro.2014.103","article-title":"Neuroplasticity and dysfunction after gastrointestinal inflammation","volume":"11","author":"Brierley","year":"2014","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2024012713305799200_CIT0012","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0163-7258(88)90029-0","article-title":"Antidromic vasodilatation and neurogenic inflammation","volume":"37","author":"Chahl","year":"1988","journal-title":"Pharmacol Ther"},{"key":"2024012713305799200_CIT0013","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/0306-4522(88)90064-4","article-title":"Local effector functions of capsaicin-sensitive sensory nerve endings: Involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides","volume":"24","author":"Holzer","year":"1988","journal-title":"Neuroscience"},{"key":"2024012713305799200_CIT0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0301-0082(94)E0017-B","article-title":"Tachykinins and calcitonin gene-related peptide [cgrp] as co-transmitters released from peripheral endings of sensory nerves","volume":"45","author":"Maggi","year":"1995","journal-title":"Prog Neurobiol"},{"key":"2024012713305799200_CIT0015","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00018-007-7148-1","article-title":"Tachykinins and their functions in the gastrointestinal tract","volume":"65","author":"Shimizu","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"2024012713305799200_CIT0016","doi-asserted-by":"crossref","first-page":"G949","DOI":"10.1152\/ajpgi.00493.2012","article-title":"Emerging neuropeptide targets in inflammation: Npy and vip","volume":"304","author":"Chandrasekharan","year":"2013","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2024012713305799200_CIT0017","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1053\/j.gastro.2017.06.051","article-title":"Vasoactive intestinal polypeptide and mast cells regulate increased passage of colonic bacteria in patients with irritable bowel syndrome","volume":"153","author":"Bednarska","year":"2017","journal-title":"Gastroenterology"},{"key":"2024012713305799200_CIT0018","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1016\/j.jpedsurg.2019.08.038","article-title":"Vasoactive intestinal peptide decreases inflammation and tight junction disruption in experimental necrotizing enterocolitis","volume":"54","author":"Seo","year":"2019","journal-title":"J Pediatr Surg"},{"key":"2024012713305799200_CIT0019","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00054725-199703000-00007","article-title":"Alterations in enteric nerve and smooth-muscle function in inflammatory bowel diseases","volume":"3","author":"Collins","year":"1997","journal-title":"Inflamm Bowel Dis"},{"key":"2024012713305799200_CIT0020","first-page":"335","article-title":"The myenteric plexus in chronic ulcerative colitis","volume":"97","author":"Storsteen","year":"1953","journal-title":"Surg Gynecol Obstet"},{"key":"2024012713305799200_CIT0021","first-page":"53","article-title":"Differentiation between crohn\u2019s disease and other inflammatory conditions by electron microscopy","volume":"201","author":"Dvorak","year":"1985","journal-title":"Ann Surg"},{"key":"2024012713305799200_CIT0022","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1136\/gut.40.6.767","article-title":"Neurochemical coding in the small intestine of patients with crohn\u2019s disease","volume":"40","author":"Belai","year":"1997","journal-title":"Gut"},{"key":"2024012713305799200_CIT0023","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.1365-2982.2001.00265.x","article-title":"Neurotransmitter coding of enteric neurones in the submucous plexus is changed in non-inflamed rectum of patients with crohn\u2019s disease","volume":"13","author":"Schneider","year":"2001","journal-title":"Neurogastroenterol Motil"},{"key":"2024012713305799200_CIT0024","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/j.1365-2982.2008.01146.x","article-title":"Enteric nervous system abnormalities in inflammatory bowel diseases","volume":"20","author":"Villanacci","year":"2008","journal-title":"Neurogastroenterol Motil"},{"key":"2024012713305799200_CIT0025","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.3390\/cells10081881","article-title":"Macrophage as a peripheral pain regulator","volume":"10","author":"Domoto","year":"2021","journal-title":"Cells"},{"key":"2024012713305799200_CIT0026","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.jcmgh.2021.07.003","article-title":"Evidence of a myenteric plexus barrier and its macrophage-dependent degradation during murine colitis: Implications in enteric neuroinflammation","volume":"12","author":"Dora","year":"2021","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"2024012713305799200_CIT0027","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cell.2018.07.048","article-title":"Self-maintaining gut macrophages are essential for intestinal homeostasis","volume":"175","author":"De Schepper","year":"2018","journal-title":"Cell"},{"key":"2024012713305799200_CIT0028","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/s12974-016-0735-z","article-title":"Adoptive transfer of m2 macrophages reduces neuropathic pain via opioid peptides","volume":"13","author":"Pannell","year":"2016","journal-title":"J Neuroinflammation"},{"key":"2024012713305799200_CIT0029","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1136\/gutjnl-2011-300123","article-title":"Cell polarity-determining proteins par-3 and pp-1 are involved in epithelial tight junction defects in coeliac disease","volume":"61","author":"Schumann","year":"2012","journal-title":"Gut"},{"key":"2024012713305799200_CIT0030","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1136\/gut.2007.136366","article-title":"Mechanisms of epithelial translocation of the alpha[2]-gliadin-33mer in coeliac sprue","volume":"57","author":"Schumann","year":"2008","journal-title":"Gut"},{"key":"2024012713305799200_CIT0031","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/nprot.2017.044","article-title":"Chemically induced mouse models of acute and chronic intestinal inflammation","volume":"12","author":"Wirtz","year":"2017","journal-title":"Nat Protoc"},{"key":"2024012713305799200_CIT0032","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/978-1-61779-527-5_19","article-title":"T cell transfer model of colitis: a great tool to assess the contribution of t cells in chronic intestinal inflammation","volume":"844","author":"Eri","year":"2012","journal-title":"Methods Mol Biol"},{"key":"2024012713305799200_CIT0033","first-page":"4557","article-title":"A guide to histomorphological evaluation of intestinal inflammation in mouse models","volume":"7","author":"Erben","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"2024012713305799200_CIT0034","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41385-021-00450-2","article-title":"Stat1 coordinates intestinal epithelial cell death during gastrointestinal infection upstream of caspase-8","volume":"15","author":"Stolzer","year":"2022","journal-title":"Mucosal Immunol"},{"key":"2024012713305799200_CIT0035","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.imlet.2020.07.007","article-title":"Plasticity of monocyte development and monocyte fates","volume":"227","author":"Trzebanski","year":"2020","journal-title":"Immunol Lett"},{"key":"2024012713305799200_CIT0036","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1159\/000213532","article-title":"Age-induced nerve cell loss in the myenteric plexus of the small intestine in man","volume":"39","author":"de Souza","year":"1993","journal-title":"Gerontology"},{"key":"2024012713305799200_CIT0037","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000213852","article-title":"A preliminary investigation of the effects of aging on the nerve cell number in the myenteric ganglia of the human colon","volume":"43","author":"Gomes","year":"1997","journal-title":"Gerontology"},{"key":"2024012713305799200_CIT0038","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1046\/j.1365-2982.1998.00102.x","article-title":"Structural abnormalities of the nervous system in crohn\u2019s disease and ulcerative colitis","volume":"10","author":"Geboes","year":"1998","journal-title":"Neurogastroenterol Motil"},{"key":"2024012713305799200_CIT0039","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/scrt387","article-title":"Enteric nervous system abnormalities are present in human necrotizing enterocolitis: potential neurotransplantation therapy","volume":"4","author":"Zhou","year":"2013","journal-title":"Stem Cell Res Ther"},{"key":"2024012713305799200_CIT0040","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.autneu.2004.10.006","article-title":"Myenteric plexus injury and apoptosis in experimental colitis","volume":"117","author":"Boyer","year":"2005","journal-title":"Auton Neurosci"},{"key":"2024012713305799200_CIT0041","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/cne.20598","article-title":"Highly regionalized neuronal expression of monocyte chemoattractant protein-1 [mcp-1\/ccl2] in rat brain: evidence for its colocalization with neurotransmitters and neuropeptides","volume":"489","author":"Banisadr","year":"2005","journal-title":"J Comp Neurol"},{"key":"2024012713305799200_CIT0042","doi-asserted-by":"crossref","first-page":"C391","DOI":"10.1152\/ajpcell.00056.2007","article-title":"Mcp-1 targeting inhibits muscularis macrophage recruitment and intestinal smooth muscle dysfunction in colonic inflammation","volume":"294","author":"Hori","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"2024012713305799200_CIT0043","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3389\/fcimb.2018.00074","article-title":"Herpes simplex virus type 1 infects enteric neurons and triggers gut dysfunction via macrophage recruitment","volume":"8","author":"Brun","year":"2018","journal-title":"Front Cell Infect Microbiol"},{"key":"2024012713305799200_CIT0044","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1136\/gut.2010.225482","article-title":"Randomised placebo-controlled trial of rituximab [anti-cd20] in active ulcerative colitis","volume":"60","author":"Leiper","year":"2011","journal-title":"Gut"},{"key":"2024012713305799200_CIT0045","first-page":"555","article-title":"The demyelinating potential of antibodies to myelin oligodendrocyte glycoprotein is related to their ability to fix complement","volume":"143","author":"Piddlesden","year":"1993","journal-title":"Am J Pathol"},{"key":"2024012713305799200_CIT0046","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1093\/brain\/aws105","article-title":"Functional identification of pathogenic autoantibody responses in patients with multiple sclerosis","volume":"135","author":"Elliott","year":"2012","journal-title":"Brain"},{"key":"2024012713305799200_CIT0047","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1002\/glia.22876","article-title":"Enteric glia express proteolipid protein 1 and are a transcriptionally unique population of glia in the mammalian nervous system","volume":"63","author":"Rao","year":"2015","journal-title":"Glia"},{"key":"2024012713305799200_CIT0048","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.molmed.2009.03.002","article-title":"Cd4 t cell differentiation and inflammatory bowel disease","volume":"15","author":"Zenewicz","year":"2009","journal-title":"Trends Mol Med"},{"key":"2024012713305799200_CIT0049","doi-asserted-by":"crossref","first-page":"738762","DOI":"10.3389\/fimmu.2021.738762","article-title":"New insights on cd8[+] t cells in inflammatory bowel disease and therapeutic approaches","volume":"12","author":"Casalegno Garduno","year":"2021","journal-title":"Front Immunol"},{"key":"2024012713305799200_CIT0050","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.tcb.2020.06.003","article-title":"The roles of cd8[+] t cell subsets in antitumor immunity","volume":"30","author":"St Paul","year":"2020","journal-title":"Trends Cell Biol"},{"key":"2024012713305799200_CIT0051","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1053\/j.gastro.2006.05.018","article-title":"Cd8+ cytotoxic t cells induce relapsing colitis in normal mice","volume":"131","author":"Nancey","year":"2006","journal-title":"Gastroenterology"},{"key":"2024012713305799200_CIT0052","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1093\/ecco-jcc\/jjv211","article-title":"Enrichment of circulating and mucosal cytotoxic cd8+ t cells is associated with postoperative endoscopic recurrence in patients with crohn\u2019s disease","volume":"10","author":"Boschetti","year":"2016","journal-title":"J Crohns Colitis"},{"key":"2024012713305799200_CIT0053","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.3389\/fimmu.2018.03116","article-title":"Pathogenic mechanisms associated with different clinical courses of multiple sclerosis","volume":"9","author":"Lassmann","year":"2018","journal-title":"Front Immunol"},{"key":"2024012713305799200_CIT0054","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/JLB.3MR0620-035R","article-title":"Neuroinflammation at single cell level: what is new","volume":"108","author":"Brandao","year":"2020","journal-title":"J Leukoc Biol"},{"key":"2024012713305799200_CIT0055","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1053\/gast.2002.37059","article-title":"Full-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome","volume":"123","author":"Tornblom","year":"2002","journal-title":"Gastroenterology"},{"key":"2024012713305799200_CIT0056","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1016\/S0002-9270(02)04359-9","article-title":"Clinical and morphofunctional features of idiopathic myenteric ganglionitis underlying severe intestinal motor dysfunction: a study of three cases","volume":"97","author":"De Giorgio","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"2024012713305799200_CIT0057","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev-physiol-020518-114525","article-title":"Visceral pain","volume":"81","author":"Grundy","year":"2019","journal-title":"Annu Rev Physiol"},{"key":"2024012713305799200_CIT0058","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fnins.2014.00023","article-title":"Calcitonin gene-related peptide is a key neurotransmitter in the neuro-immune axis","volume":"8","author":"Assas","year":"2014","journal-title":"Front Neurosci"},{"key":"2024012713305799200_CIT0059","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1002\/eji.201444553","article-title":"Neuroimmunological communication via CGRP promotes the development of a regulatory phenotype in TLR4-stimulated macrophages","volume":"44","author":"Baliu-Piqu\u00e9","year":"2014","journal-title":"Eur J Immunol"},{"key":"2024012713305799200_CIT0060","first-page":"657","article-title":"Calcitonin gene-related peptide mediates the protective effect of sensory nerves in a model of colonic injury","volume":"286","author":"Reinshagen","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"2024012713305799200_CIT0061","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.dld.2011.08.030","article-title":"Opposite effects of substance p and calcitonin gene-related peptide in oxazolone colitis","volume":"44","author":"Engel","year":"2012","journal-title":"Dig Liver Dis"},{"key":"2024012713305799200_CIT0062","first-page":"908","article-title":"Rectal substance p concentrations are increased in ulcerative colitis but not in crohn\u2019s disease","volume":"88","author":"Bernstein","year":"1993","journal-title":"Am J Gastroenterol"},{"key":"2024012713305799200_CIT0063","first-page":"176","article-title":"Immunocytochemical localization of vasoactive intestinal peptide and substance p in the colon from normal subjects and patients with inflammatory bowel disease","volume":"87","author":"Mazumdar","year":"1992","journal-title":"Am J Gastroenterol"},{"key":"2024012713305799200_CIT0064","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF00327774","article-title":"Nerve fibers immunoreactive for substance p and calcitonin gene-related peptide in the cervical spinal ventral roots of the mouse","volume":"277","author":"Kimura","year":"1994","journal-title":"Cell Tissue Res"},{"key":"2024012713305799200_CIT0065","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1111\/bph.13482","article-title":"5-ht3 receptors promote colonic inflammation via activation of substance p\/neurokinin-1 receptors in dextran sulphate sodium-induced murine colitis","volume":"173","author":"Utsumi","year":"2016","journal-title":"Br J Pharmacol"},{"key":"2024012713305799200_CIT0066","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1242\/dev.00433","article-title":"Gdnf availability determines enteric neuron number by controlling precursor proliferation","volume":"130","author":"Gianino","year":"2003","journal-title":"Development"},{"key":"2024012713305799200_CIT0067","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.bcp.2014.01.005","article-title":"Trpv4: new therapeutic target for inflammatory bowel diseases","volume":"89","author":"Vergnolle","year":"2014","journal-title":"Biochem Pharmacol"},{"key":"2024012713305799200_CIT0068","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1136\/gut.2009.192567","article-title":"Potentiation of trpv4 signalling by histamine and serotonin: an important mechanism for visceral hypersensitivity","volume":"59","author":"Cenac","year":"2010","journal-title":"Gut"},{"key":"2024012713305799200_CIT0069","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1053\/j.gastro.2008.05.024","article-title":"Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms","volume":"135","author":"Cenac","year":"2008","journal-title":"Gastroenterology"},{"key":"2024012713305799200_CIT0070","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.immuni.2018.04.021","article-title":"Trpv4 channel signaling in macrophages promotes gastrointestinal motility via direct effects on smooth muscle cells","volume":"49","author":"Luo","year":"2018","journal-title":"Immunity"}],"container-title":["Journal of Crohn's and Colitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/advance-article-pdf\/doi\/10.1093\/ecco-jcc\/jjad122\/53186831\/jjad122.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/18\/1\/121\/56432816\/jjad122.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/18\/1\/121\/56432816\/jjad122.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T08:32:16Z","timestamp":1706344336000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article\/18\/1\/121\/7241297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,11]]},"references-count":70,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,8,11]]},"published-print":{"date-parts":[[2024,1,27]]}},"URL":"https:\/\/doi.org\/10.1093\/ecco-jcc\/jjad122","relation":{},"ISSN":["1873-9946","1876-4479"],"issn-type":[{"value":"1873-9946","type":"print"},{"value":"1876-4479","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,1,1]]},"published":{"date-parts":[[2023,8,11]]}}}