{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:21:55Z","timestamp":1792794115529,"version":"4.5.0"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Grant Agency of Charles University","award":["166119"],"award-info":[{"award-number":["166119"]}],"id":[{"id":"https:\/\/ror.org\/024d6js02","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Institute of Virology and Bacteriology","award":["LX22NPO5103"],"award-info":[{"award-number":["LX22NPO5103"]}],"id":[{"id":"https:\/\/ror.org\/04xrjem68","id-type":"ROR","asserted-by":"crossref"}]},{"name":"European Union\u2014Next Generation","id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"crossref"}]},{"name":"conceptual development of research organization","award":["00064203"],"award-info":[{"award-number":["00064203"]}]},{"name":"Ministry of Health, the Czech Republic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Treatment with anti-tumour necrosis factor \u03b1 antibodies [anti-TNF] changes the dysbiotic faecal bacteriome in Crohn\u2019s disease [CD]. However, it is not known whether these changes are due to decreasing mucosal inflammatory activity or whether similar bacteriome reactions might be observed in gut-healthy subjects. Therefore, we explored changes in the faecal bacteriome and metabolome upon anti-TNF administration [and therapeutic response] in children with CD and contrasted those to anti-TNF-treated children with juvenile idiopathic arthritis [JIA].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Faecal samples collected longitudinally before and during anti-TNF therapy were analysed with regard to the bacteriome by massively parallel sequencing of the 16S rDNA [V4 region] and the faecal metabolome by 1H nuclear magnetic resonance imaging. The response to treatment by mucosal healing was assessed by the MINI index at 3 months after the treatment started. We also tested several representative gut bacterial strains for in vitro growth inhibition by infliximab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We analysed 530 stool samples from 121 children [CD 54, JIA 18, healthy 49]. Bacterial community composition changed on anti-TNF in CD: three members of the class Clostridia increased on anti-TNF, whereas the class Bacteroidia decreased. Among faecal metabolites, glucose and glycerol increased, whereas isoleucine and uracil decreased. Some of these changes differed by treatment response [mucosal healing] after anti-TNF. No significant changes in the bacteriome or metabolome were noted upon anti-TNF in JIA. Bacterial growth was not affected by infliximab in a disc diffusion test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that gut mucosal healing is responsible for the bacteriome and metabolome changes observed in CD, rather than any general effect of anti-TNF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjad126","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T08:27:25Z","timestamp":1690446445000},"page":"106-120","source":"Crossref","is-referenced-by-count":15,"title":["Faecal Bacteriome and Metabolome Profiles Associated with Decreased Mucosal Inflammatory Activity Upon Anti-TNF Therapy in Paediatric Crohn\u2019s Disease"],"prefix":"10.1093","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9813-5290","authenticated-orcid":false,"given":"Jakub","family":"Hurych","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, 2nd Faculty of Medicine, Charles University and Motol University Hospital , Prague, Czechia"},{"name":"Department of Paediatrics, 2nd Faculty of Medicine, Charles University and Motol University Hospital , Prague, Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Mascellani Bergo","sequence":"additional","affiliation":[{"name":"Department of Food Science, Faculty of Agrobiology, Food and Natural Resources, Czech Univesity of Life Sciences , Prague, Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tereza","family":"Lerchova","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, 2nd Faculty of Medicine, Charles University and Motol University Hospital , Prague, 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