{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:15:56Z","timestamp":1793103356715,"version":"4.5.0"},"reference-count":170,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>Inflammatory bowel disease [IBD] comprises an immune-mediated group of chronic gastrointestinal disorders. Patients with IBD may experience extraintestinal manifestations, such as hepatobiliary complications. This meta-analysis aims to assess the prevalence of different hepatic manifestations in IBD patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>For this systematic review and meta-analysis, PubMed, Scopus, Web of Science, and Embase were searched until July 20, 2022, by specifying keywords for IBD, hepatic manifestations, and study type. Full texts of cohort studies in English that examined the prevalence of different hepatic manifestations were included in this study. The primary outcome was the overall prevalence of hepatic manifestations in IBD patients. For the statistical analysis, a proportion by random effect model meta-analysis was performed. The registration number for the protocol of this study in PROSPERO is CRD42022369595.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>From the 4421 articles retrieved from the primary search, 118 met the inclusion criteria and were included in the final analysis. After a pooled analysis of 1 729 128 patients, the overall prevalence of hepatic manifestations was 3.49% (95% confidence interval [CI]: 3.31\u20133.68%; I2: 99.55%). The pooled prevalence of non-alcoholic fatty liver disease in 228 216 patients was 26.1% [95% CI: 22.1\u201330.2%; I2: 99.018%]. After pooled analysis of 9642 patients, the prevalence of primary sclerosing cholangitis was 1.67% [95% CI: 1.47\u20131.88%; I2: 99.10%]. The pooled prevalence of biliary stones was 4.1% [95% CI: 3.6\u20134.7%; I2: 97.43%]. Autoimmune hepatitis (0.51% [95% CI: 0.26\u20130.75%]; I2: 85.36%) and portal vein thrombosis (0.21% [95% CI: 0.08\u20130.33%]; I2: 97.95%) are considered as rare manifestations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study summarizes the prevalence and importance of different hepatic manifestations in IBD patients. These findings are crucial for the management of extraintestinal manifestations, especially hepatic manifestations, in IBD patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjad157","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T13:26:52Z","timestamp":1694438812000},"page":"360-374","source":"Crossref","is-referenced-by-count":17,"title":["Prevalence of Hepatobiliary Manifestations in Inflammatory Bowel Disease: A GRADE Assessed Systematic Review and Meta-Analysis of more than 1.7 Million Patients"],"prefix":"10.1093","volume":"18","author":[{"given":"Alireza","family":"Beheshti Maal","sequence":"first","affiliation":[{"name":"Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences , Tehran , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Amin","family":"Shahrbaf","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR , Tehran , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahareh","family":"Sadri","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR , Tehran , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikoo","family":"Hossein-Khannazer","sequence":"additional","affiliation":[{"name":"Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences , Tehran , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Ali","family":"Mansournia","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences , Tehran , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massoud","family":"Vosough","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR , Tehran , Iran"},{"name":"Experimental Cancer Medicine, Institution for Laboratory Medicine, Karolinska Institute, Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,11]]},"reference":[{"key":"2024030118332374800_CIT0001","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.suc.2019.08.001","article-title":"Inflammatory bowel disease presentation and diagnosis","volume":"99","author":"Flynn","year":"2019","journal-title":"Surg Clin North Am"},{"key":"2024030118332374800_CIT0002","doi-asserted-by":"crossref","first-page":"113","DOI":"10.25122\/jml-2018-0075","article-title":"A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease","volume":"12","author":"Seyedian","year":"2019","journal-title":"J Med Life"},{"key":"2024030118332374800_CIT0003","doi-asserted-by":"crossref","first-page":"159","DOI":"10.5217\/ir.2021.00115","article-title":"Update on the epidemiology of inflammatory bowel disease in Asia: where are we now","volume":"20","author":"Park","year":"2022","journal-title":"Intest Res"},{"key":"2024030118332374800_CIT0004","doi-asserted-by":"crossref","first-page":"551","DOI":"10.3389\/fimmu.2015.00551","article-title":"Inflammatory bowel disease: genetics, epigenetics, and pathogenesis","volume":"6","author":"Loddo","year":"2015","journal-title":"Front Immunol"},{"key":"2024030118332374800_CIT0005","first-page":"235","article-title":"Extraintestinal manifestations of inflammatory bowel disease","volume":"7","author":"Levine","year":"2011","journal-title":"Gastroenterol Hepatol [N Y]"},{"key":"2024030118332374800_CIT0006","volume-title":"Extraintestinal Manifestations of Inflammatory Bowel Disease.","author":"Malik","year":"2022"},{"key":"2024030118332374800_CIT0007","first-page":"31","article-title":"Cutaneous manifestations in inflammatory bowel disease","volume":"20","author":"Ungureanu","year":"2020","journal-title":"Exp Ther Med"},{"key":"2024030118332374800_CIT0008","doi-asserted-by":"crossref","first-page":"7327","DOI":"10.3748\/wjg.v19.i42.7327","article-title":"Hepatobiliary manifestations in inflammatory bowel disease: the gut, the drugs and the liver","volume":"19","author":"Rojas-Feria","year":"2013","journal-title":"World J Gastroenterol"},{"key":"2024030118332374800_CIT0009","doi-asserted-by":"crossref","first-page":"5359","DOI":"10.3390\/jcm10225359","article-title":"Liver pathology in children with diagnosed inflammatory bowel disease\u2014a single center experience","volume":"10","author":"Daniluk","year":"2021","journal-title":"J Clin Med"},{"key":"2024030118332374800_CIT0010","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"2024030118332374800_CIT0011","doi-asserted-by":"crossref","first-page":"8623","DOI":"10.3390\/ijerph18168623","article-title":"Selecting risk of bias tools for observational studies for a systematic review of anthropometric measurements and dental caries among children","volume":"18","author":"Mamikutty","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"2024030118332374800_CIT0012","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"key":"2024030118332374800_CIT0013","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.jclinepi.2014.03.003","article-title":"In meta-analyses of proportion studies, funnel plots were found to be an inaccurate method of assessing publication bias","volume":"67","author":"Hunter","year":"2014","journal-title":"J Clin Epidemiol"},{"key":"2024030118332374800_CIT0014","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/XEB.0000000000000141","article-title":"A new improved graphical and quantitative method for detecting bias in meta-analysis","volume":"16","author":"Furuya-Kanamori","year":"2018","journal-title":"Int J Evid Based Healthc"},{"key":"2024030118332374800_CIT0015","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1007\/BF02234596","article-title":"Flow cytometric and histologic evaluation in a large cohort of patients with ulcerative colitis: correlation with clinical characteristics and impact on surveillance","volume":"44","author":"Holzmann","year":"2001","journal-title":"Dis Colon Rectum"},{"key":"2024030118332374800_CIT0016","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/00004836-200110000-00008","article-title":"Primary sclerosing cholangitis in patients with inflammatory bowel disease in Turkey","volume":"33","author":"Parlak","year":"2001","journal-title":"J Clin Gastroenterol"},{"key":"2024030118332374800_CIT0017","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.3748\/wjg.v9.i10.2300","article-title":"Association of extraintestinal manifestations of inflammatory bowel disease in a province of western Hungary with disease phenotype: results of a 25-year follow-up study","volume":"9","author":"Lakatos","year":"2003","journal-title":"World J Gastroenterol"},{"key":"2024030118332374800_CIT0018","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/00004836-200305000-00012","article-title":"Sonographic prevalence of liver steatosis and biliary tract stones in patients with inflammatory bowel disease: study of 511 subjects at a single center","volume":"36","author":"Bargiggia","year":"2003","journal-title":"J Clin Gastroenterol"},{"key":"2024030118332374800_CIT0019","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/s00384-004-0598-0","article-title":"Sonographic detection of perihepatic lymphadenopathy is an indicator for primary sclerosing cholangitis in patients with inflammatory bowel disease","volume":"19","author":"Hirche","year":"2004","journal-title":"Int J Colorectal Dis"},{"key":"2024030118332374800_CIT0020","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1136\/gut.2004.046615","article-title":"PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis","volume":"54","author":"Loftus Jr","year":"2005","journal-title":"Gut"},{"key":"2024030118332374800_CIT0021","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.3748\/wjg.v11.i17.2630","article-title":"Epidemiological characteristics of inflammatory bowel disease in North-Eastern Poland","volume":"11","author":"Wiercinska-Drapalo","year":"2005","journal-title":"World J Gastroenterol"},{"key":"2024030118332374800_CIT0022","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1111\/j.1440-1746.2005.03905.x","article-title":"Inflammatory bowel disease in Iran: a review of 457 cases","volume":"20","author":"Aghazadeh","year":"2005","journal-title":"J Gastroenterol Hepatol"},{"key":"2024030118332374800_CIT0023","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1572-0241.2006.00947.x","article-title":"Abnormal hepatic biochemistries in patients with inflammatory bowel disease","volume":"102","author":"Mendes","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"2024030118332374800_CIT0024","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1002\/hep.21537","article-title":"Incidence and risk factors for gallstones in patients with inflammatory bowel disease: a large case-control study","volume":"45","author":"Parente","year":"2007","journal-title":"Hepatology"},{"key":"2024030118332374800_CIT0025","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/01.meg.0000243883.47938.aa","article-title":"Relationship between clinical features of Crohn\u2019s disease and the risk of developing extraintestinal manifestations","volume":"19","author":"Barreiro-de Acosta","year":"2007","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2024030118332374800_CIT0026","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1080\/00365520701800266","article-title":"Histopathology of liver biopsies from a thiopurine-naive inflammatory bowel disease cohort: prevalence of nodular regenerative hyperplasia","volume":"43","author":"De Boer","year":"2008","journal-title":"Scand J Gastroenterol"},{"key":"2024030118332374800_CIT0027","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/ibd.20529","article-title":"Prevalence of penetrating disease and extraintestinal manifestations of Crohn\u2019s disease detected with CT enterography","volume":"14","author":"Bruining","year":"2008","journal-title":"Inflamm Bowel Dis"},{"key":"2024030118332374800_CIT0028","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/ibd.20604","article-title":"Development of extraintestinal manifestations in pediatric patients with inflammatory bowel disease","volume":"15","author":"Jose","year":"2009","journal-title":"Inflamm Bowel Dis"},{"key":"2024030118332374800_CIT0029","first-page":"454","article-title":"Epidemiologic characteristics of 500 patients with inflammatory bowel disease in Iran studied from 2004 through 2007","volume":"12","author":"Vahedi","year":"2009","journal-title":"Arch Iran Med"},{"key":"2024030118332374800_CIT0030","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s10654-009-9365-4","article-title":"Incidence and prognosis of cholangiocarcinoma in Danish patients with and without inflammatory bowel disease: a national cohort study, 1978-2003","volume":"24","author":"Erichsen","year":"2009","journal-title":"Eur J Epidemiol"},{"key":"2024030118332374800_CIT0031","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1038\/ajg.2009.343","article-title":"Risk factors for abnormal liver function tests in patients with ileal pouch-anal anastomosis for underlying inflammatory bowel disease","volume":"104","author":"Navaneethan","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"2024030118332374800_CIT0032","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/MPG.0b013e3181ca4db4","article-title":"Extraintestinal manifestations of pediatric inflammatory bowel disease and their relation to disease type and severity","volume":"51","author":"Dotson","year":"2010","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2024030118332374800_CIT0033","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1007\/s10620-010-1236-z","article-title":"Incidence and risk of intestinal and extra-intestinal complications in medicaid patients with inflammatory bowel disease: a 5-year population-based study","volume":"55","author":"Arora","year":"2010","journal-title":"Dig Dis Sci"},{"key":"2024030118332374800_CIT0034","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S1665-2681(19)31615-1","article-title":"Prevalence and factors associated with the presence of abnormal function liver tests in patients with ulcerative colitis","volume":"9","author":"Yamamoto-Furusho","year":"2010","journal-title":"Ann Hepatol"},{"key":"2024030118332374800_CIT0035","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1002\/ibd.21569","article-title":"Clinical characteristics of ulcerative colitis associated with primary sclerosing cholangitis in Korea","volume":"17","author":"Ye","year":"2011","journal-title":"Inflamm Bowel Dis"},{"key":"2024030118332374800_CIT0036","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/ajg.2010.343","article-title":"Frequency and risk factors for extraintestinal manifestations in the Swiss inflammatory bowel disease cohort","volume":"106","author":"Vavricka","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"2024030118332374800_CIT0037","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jcma.2012.02.017","article-title":"Long-term follow-up of ulcerative colitis in Taiwan","volume":"75","author":"Wei","year":"2012","journal-title":"J Chin Med Assoc"},{"key":"2024030118332374800_CIT0038","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.crohns.2012.10.008","article-title":"Clinical presentation of venous thromboembolism in inflammatory bowel disease","volume":"7","author":"Papay","year":"2013","journal-title":"J Crohns Colitis"},{"key":"2024030118332374800_CIT0039","doi-asserted-by":"crossref","first-page":"e279","DOI":"10.1016\/j.crohns.2012.10.015","article-title":"Risk factors of non-alcoholic fatty liver disease in patients with inflammatory bowel disease","volume":"7","author":"Sourianarayanane","year":"2013","journal-title":"J Crohns Colitis"},{"key":"2024030118332374800_CIT0040","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1097\/MPG.0b013e3182801e43","article-title":"Venous thrombotic events in hospitalized children and adolescents with inflammatory bowel disease","volume":"56","author":"Nylund","year":"2013","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2024030118332374800_CIT0041","doi-asserted-by":"crossref","first-page":"17463","DOI":"10.3748\/wjg.v20.i46.17463","article-title":"Extraintestinal manifestations in a large series of Italian inflammatory bowel disease patients","volume":"20","author":"Zippi","year":"2014","journal-title":"World J Gastroenterol"},{"key":"2024030118332374800_CIT0042","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000363228","article-title":"Extraintestinal manifestations of inflammatory bowel disease and the influence of smoking","volume":"90","author":"Roberts","year":"2014","journal-title":"Digestion"},{"key":"2024030118332374800_CIT0043","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4137\/CGast.S13125","article-title":"Liver function test abnormalities in patients with inflammatory bowel diseases: a hospital-based survey","volume":"7","author":"Cappello","year":"2014","journal-title":"Clin Med Insights Gastroenterol"},{"key":"2024030118332374800_CIT0044","doi-asserted-by":"crossref","first-page":"12269","DOI":"10.3748\/wjg.v20.i34.12269","article-title":"Smoking increases the risk of extraintestinal manifestations in Crohn\u2019s disease","volume":"20","author":"Ott","year":"2014","journal-title":"World J Gastroenterol"},{"key":"2024030118332374800_CIT0045","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1097\/MIB.0000000000000558","article-title":"Abnormal liver biochemistry is common in pediatric inflammatory bowel disease: prevalence and associations","volume":"21","author":"Valentino","year":"2015","journal-title":"Inflamm Bowel Dis"},{"key":"2024030118332374800_CIT0046","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1111\/jgh.12947","article-title":"Appearance of hepatobiliary diseases in a population-based cohort with inflammatory bowel diseases (Inflammatory Bowel Disease Cohort of the Uppsala Region)","volume":"30","author":"R\u00f6nnblom","year":"2015","journal-title":"J Gastroenterol Hepatol"},{"key":"2024030118332374800_CIT0047","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1097\/MIB.0000000000000429","article-title":"Chronological order of appearance of extraintestinal manifestations relative to the time of IBD diagnosis in the swiss inflammatory bowel disease cohort","volume":"21","author":"Vavricka","year":"2015","journal-title":"Inflamm Bowel Dis"},{"key":"2024030118332374800_CIT0048","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3109\/00365521.2014.991752","article-title":"Extraintestinal manifestations in Crohn\u2019s disease and ulcerative colitis: results from a prospective, population-based European inception cohort","volume":"50","author":"Isene","year":"2015","journal-title":"Scand J Gastroenterol"},{"key":"2024030118332374800_CIT0049","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s12664-015-0598-8","article-title":"Extraintestinal manifestations in inflammatory bowel disease: prevalence and predictors in Indian patients","volume":"34","author":"Bandyopadhyay","year":"2015","journal-title":"Indian J Gastroenterol"},{"key":"2024030118332374800_CIT0050","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s12664-015-0538-7","article-title":"Extraintestinal manifestations of inflammatory bowel disease and intestinal tuberculosis: frequency and relation with disease phenotype","volume":"34","author":"Singh","year":"2015","journal-title":"Indian J Gastroenterol"},{"key":"2024030118332374800_CIT0051","first-page":"200","article-title":"Frequency and risk factors of primary sclerosing cholangitis among patients with inflammatory bowel disease in North-East of Iran","volume":"8","author":"Khorashad","year":"2015","journal-title":"Gastroenterol Hepatol Bed Bench"},{"key":"2024030118332374800_CIT0052","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1177\/1708538114541799","article-title":"The increasing incidence of thromboembolic events among hospitalized patients with inflammatory bowel disease","volume":"23","author":"Kuy","year":"2015","journal-title":"Vascular"},{"key":"2024030118332374800_CIT0053","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1097\/MEG.0000000000000350","article-title":"Liver steatosis is a risk factor for hepatotoxicity in patients with inflammatory bowel disease under immunosuppressive treatment","volume":"27","author":"Schr\u00f6der","year":"2015","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2024030118332374800_CIT0054","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/MPG.0000000000001078","article-title":"Clinical features and risk factors of autoimmune liver involvement in pediatric inflammatory bowel disease","volume":"63","author":"Bramuzzo","year":"2016","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2024030118332374800_CIT0055","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1007\/s10620-016-4195-1","article-title":"Extra-gastrointestinal manifestations of inflammatory bowel disease may be less common than previously reported","volume":"61","author":"Card","year":"2016","journal-title":"Dig Dis Sci"},{"key":"2024030118332374800_CIT0056","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1097\/MIB.0000000000000832","article-title":"Incidence and predictors of nonalcoholic fatty liver disease by serum biomarkers in patients with inflammatory bowel disease","volume":"22","author":"Bessissow","year":"2016","journal-title":"Inflamm Bowel Dis"},{"key":"2024030118332374800_CIT0057","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1097\/MIB.0000000000000587","article-title":"Multiyear patterns of serum inflammatory biomarkers and risk of colorectal neoplasia in patients with ulcerative colitis","volume":"22","author":"Koutroubakis","year":"2016","journal-title":"Inflamm Bowel Dis"},{"key":"2024030118332374800_CIT0058","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/ecco-jcc\/jjv232","article-title":"Prevalence and characteristics of extra-intestinal manifestations in a large cohort of Greek patients with inflammatory bowel disease","volume":"10","author":"Karmiris","year":"2016","journal-title":"J Crohns Colitis"},{"key":"2024030118332374800_CIT0059","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1053\/j.gastro.2016.06.021","article-title":"Prevalence of sclerosing cholangitis detected by magnetic resonance cholangiography in patients with long-term inflammatory bowel disease","volume":"151","author":"Lunder","year":"2016","journal-title":"Gastroenterology"},{"key":"2024030118332374800_CIT0060","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/liv.12875","article-title":"Pyogenic liver abscess in patients with inflammatory bowel disease: a nationwide cohort study","volume":"36","author":"Lin","year":"2016","journal-title":"Liver Int"},{"key":"2024030118332374800_CIT0061","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1177\/2050640615627533","article-title":"Risk factors for complications in patients with ulcerative colitis","volume":"4","author":"Manser","year":"2016","journal-title":"United European Gastroenterol J"},{"key":"2024030118332374800_CIT0062","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1097\/MIB.0000000000001085","article-title":"Epidemiology and risk factors of nonalcoholic fatty liver disease among patients with inflammatory bowel disease","volume":"23","author":"Glassner","year":"2017","journal-title":"Inflamm Bowel Dis"},{"key":"2024030118332374800_CIT0063","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/MPG.0000000000001455","article-title":"Extraintestinal manifestations of pediatric inflammatory bowel disease: prevalence, presentation, and anti-TNF treatment","volume":"65","author":"Greuter","year":"2017","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2024030118332374800_CIT0064","doi-asserted-by":"crossref","first-page":"e7653","DOI":"10.1097\/MD.0000000000007653","article-title":"Gallstone prevalence and risk factors in patients with ulcerative colitis in Korean population","volume":"96","author":"Jeong","year":"2017","journal-title":"Medicine [Baltim]"},{"key":"2024030118332374800_CIT0065","first-page":"10633","article-title":"High incidence of non-alcoholic fatty liver disease in patients with Crohn\u2019s disease but not ulcerative colitis","volume":"10","author":"Li","year":"2017","journal-title":"Int J Clin Exp Path"},{"key":"2024030118332374800_CIT0066","doi-asserted-by":"crossref","first-page":"131","DOI":"10.5152\/tjg.2017.16562","article-title":"Hypergammaglobulinemia is a marker of extraintestinal manifestations in pediatric inflammatory bowel disease","volume":"28","author":"Matar","year":"2017","journal-title":"Turkish J Gastroenterol"},{"key":"2024030118332374800_CIT0067","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/apt.13940","article-title":"The impact of co-existing immune-mediated diseases on phenotype and outcomes in inflammatory bowel diseases","volume":"45","author":"Conway","year":"2017","journal-title":"Aliment Pharmacol Ther"},{"key":"2024030118332374800_CIT0068","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/jgh.13596","article-title":"Overall and cause-specific mortality in Korean patients with inflammatory bowel disease: a hospital-based cohort study","volume":"32","author":"Lee","year":"2017","journal-title":"J Gastroenterol Hepatol"},{"key":"2024030118332374800_CIT0069","doi-asserted-by":"crossref","first-page":"6137","DOI":"10.3748\/wjg.v23.i33.6137","article-title":"Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases","volume":"23","author":"Halling","year":"2017","journal-title":"World J Gastroenterol"},{"key":"2024030118332374800_CIT0070","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12876-017-0578-9","article-title":"Prevalence of paediatric inflammatory bowel disease in Sweden: a nationwide population-based register study","volume":"17","author":"Ludvigsson","year":"2017","journal-title":"BMC Gastroenterol"},{"key":"2024030118332374800_CIT0071","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/MEG.0000000000000747","article-title":"Primary sclerosing cholangitis in the Swiss Inflammatory Bowel Disease Cohort Study: prevalence, risk factors, and long-term follow-up","volume":"29","author":"Fraga","year":"2017","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2024030118332374800_CIT0072","doi-asserted-by":"crossref","first-page":"e0185193","DOI":"10.1371\/journal.pone.0185193","article-title":"Risk factors for gallstones and kidney stones in a cohort of patients with inflammatory bowel diseases","volume":"12","author":"Fagagnini","year":"2017","journal-title":"PLoS One"},{"key":"2024030118332374800_CIT0073","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1111\/hepr.12828","article-title":"Significance of non-alcoholic fatty liver disease in Crohn\u2019s disease: a retrospective cohort study","volume":"47","author":"Sagami","year":"2017","journal-title":"Hepatol Res"},{"key":"2024030118332374800_CIT0074","doi-asserted-by":"crossref","first-page":"171","DOI":"10.4103\/sjg.SJG_490_17","article-title":"Natural history and outcome of inflammatory bowel diseases in children in Saudi Arabia: a single-center experience","volume":"24","author":"Alreheili","year":"2018","journal-title":"Saudi J Gastroenterol"},{"key":"2024030118332374800_CIT0075","doi-asserted-by":"crossref","first-page":"e0206450","DOI":"10.1371\/journal.pone.0206450","article-title":"Non-alcoholic fatty liver disease in underweight patients with inflammatory bowel disease: a case-control study","volume":"13","author":"Adams","year":"2018","journal-title":"PLoS One"},{"key":"2024030118332374800_CIT0076","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.dld.2018.06.024","article-title":"Systematic screening for primary sclerosing cholangitis with magnetic resonance cholangiography in inflammatory bowel disease","volume":"50","author":"Belle","year":"2018","journal-title":"Dig Liver Dis"},{"key":"2024030118332374800_CIT0077","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1097\/MEG.0000000000001072","article-title":"Age at disease onset of inflammatory bowel disease is associated with later extraintestinal manifestations and complications","volume":"30","author":"Herzog","year":"2018","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2024030118332374800_CIT0078","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3390\/ijerph15030513","article-title":"Association between inflammatory bowel disease and cholelithiasis: a nationwide population-based cohort study","volume":"15","author":"Chen","year":"2018","journal-title":"Int J Environ Res Public Health"},{"key":"2024030118332374800_CIT0079","doi-asserted-by":"crossref","first-page":"e0209352","DOI":"10.1371\/journal.pone.0209352","article-title":"Clinical characteristics and outcomes of primary sclerosing cholangitis and ulcerative colitis in Japanese patients","volume":"13","author":"Kumagai","year":"2018","journal-title":"PLoS One"},{"key":"2024030118332374800_CIT0080","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/ecco-jcc\/jjy040","article-title":"Colectomy rates in ulcerative colitis are low and decreasing: 10-year follow-up data from the Swiss IBD cohort study","volume":"12","author":"Parragi","year":"2018","journal-title":"J Crohns Colitis"},{"key":"2024030118332374800_CIT0081","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1093\/ibd\/izy065","article-title":"Extraintestinal manifestations in vedolizumab and anti-TNF-treated patients with inflammatory bowel disease","volume":"24","author":"Dubinsky","year":"2018","journal-title":"Inflamm Bowel Dis"},{"key":"2024030118332374800_CIT0082","doi-asserted-by":"crossref","first-page":"44","DOI":"10.12998\/wjcc.v6.i4.44","article-title":"High prevalence of cholestasis, with increased conjugated bile acids in inflammatory bowel diseases patients","volume":"6","author":"Girardin","year":"2018","journal-title":"World J Clin Cases"},{"key":"2024030118332374800_CIT0083","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1093\/ibd\/izy128","article-title":"IRGM gene variants modify the relationship between visceral adipose tissue and NAFLD in patients with Crohn\u2019s disease","volume":"24","author":"Simon","year":"2018","journal-title":"Inflamm Bowel Dis"},{"key":"2024030118332374800_CIT0084","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/apt.14893","article-title":"Malignancy and mortality in paediatric-onset inflammatory bowel disease: a 3-year prospective, multinational study from the paediatric IBD Porto group of ESPGHAN","volume":"48","author":"Joosse","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"key":"2024030118332374800_CIT0085","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1093\/ibd\/izy051","article-title":"Nonalcoholic fatty liver disease in inflammatory bowel disease: prevalence and risk factors","volume":"24","author":"Principi","year":"2018","journal-title":"Inflamm Bowel Dis"},{"key":"2024030118332374800_CIT0086","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1093\/ecco-jcc\/jjy061","article-title":"Phenotype and clinical course of inflammatory bowel disease with co-existent celiac disease","volume":"12","author":"Tse","year":"2018","journal-title":"J Crohns Colitis"},{"key":"2024030118332374800_CIT0087","doi-asserted-by":"crossref","first-page":"e0200363","DOI":"10.1371\/journal.pone.0200363","article-title":"Prevalence of extraintestinal manifestations in Korean inflammatory bowel disease patients","volume":"13","author":"Yang","year":"2018","journal-title":"PLoS One"},{"key":"2024030118332374800_CIT0088","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/ecco-jcc\/jjy166","article-title":"The association of inflammatory bowel diseases with autoimmune disorders: a report from the epi-iirn","volume":"13","author":"Yehuda","year":"2019","journal-title":"J Crohns Colitis"},{"key":"2024030118332374800_CIT0089","doi-asserted-by":"crossref","first-page":"e7194","DOI":"10.7717\/peerj.7194","article-title":"Clinical outcomes and risk factors of secondary extraintestinal manifestation in ulcerative colitis: results of a multicenter and long-term follow-up retrospective study","volume":"7","author":"Xu","year":"2019","journal-title":"PeerJ"},{"key":"2024030118332374800_CIT0090","doi-asserted-by":"crossref","first-page":"139","DOI":"10.5152\/tjg.2018.18221","article-title":"Colorectal cancer and dysplasia risk of ulcerative colitis patients in a tertiary referral center in Turkey","volume":"30","author":"\u00dcnal","year":"2019","journal-title":"Turk J Gastroenterol"},{"key":"2024030118332374800_CIT0091","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/apt.15076","article-title":"Comorbid immune-mediated diseases in inflammatory bowel disease: a nation-wide population-based study","volume":"49","author":"Park","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"key":"2024030118332374800_CIT0092","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1016\/j.cgh.2019.02.045","article-title":"Crohn\u2019s disease is associated with an increased prevalence of nonalcoholic fatty liver disease: a cross-sectional study using magnetic resonance proton density fat fraction mapping","volume":"17","author":"McHenry","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2024030118332374800_CIT0093","doi-asserted-by":"crossref","first-page":"7604939","DOI":"10.1155\/2019\/7604939","article-title":"Frequency of hepatobiliary manifestations and concomitant liver disease in inflammatory bowel disease patients","volume":"2019","author":"Silva","year":"2019","journal-title":"Biomed Res Int"},{"key":"2024030118332374800_CIT0094","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1097\/MEG.0000000000001319","article-title":"Hepatic steatosis and patients with inflammatory bowel disease: when transient elastography makes the difference","volume":"31","author":"Arieira","year":"2019","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2024030118332374800_CIT0095","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12876-019-0967-3","article-title":"Hepatobiliary and pancreatic manifestations in inflammatory bowel diseases: a referral center study","volume":"19","author":"Fousekis","year":"2019","journal-title":"BMC Gastroenterol"},{"key":"2024030118332374800_CIT0096","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000495289","article-title":"The incidence and risk factors of venous thromboembolism in patients with inflammatory bowel disease: a prospective multicenter cohort study","volume":"100","author":"Ando","year":"2019","journal-title":"Digestion"},{"key":"2024030118332374800_CIT0097","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jpeds.2019.07.065","article-title":"Inflammatory bowel disease in children with elevated serum gamma glutamyltransferase levels","volume":"215","author":"Chandrakumar","year":"2019","journal-title":"J Pediatr"},{"key":"2024030118332374800_CIT0098","doi-asserted-by":"crossref","first-page":"5676","DOI":"10.3748\/wjg.v25.i37.5676","article-title":"Nonalcoholic fatty liver disease in patients with inflammatory bowel disease: beyond the natural history","volume":"25","author":"Magr\u00ec","year":"2019","journal-title":"World J Gastroenterol"},{"key":"2024030118332374800_CIT0099","doi-asserted-by":"crossref","first-page":"S173","DOI":"10.33549\/physiolres.934302","article-title":"Pathophysiology and risk factors for cholelithiasis in patients with Crohn\u2019s disease","volume":"68","author":"Sturdik","year":"2019","journal-title":"Physiol Res"},{"key":"2024030118332374800_CIT0100","doi-asserted-by":"crossref","first-page":"68","DOI":"10.5472\/marumj.570907","article-title":"Prevalence of fatty liver disease in patients with inflammatory bowel disease: a transient elastography study on the basis of a controlled attenuation parameter","volume":"32","author":"Kani","year":"2019","journal-title":"Marmara Med Journal"},{"key":"2024030118332374800_CIT0101","first-page":"283","article-title":"Prevalence of non-alcoholic fatty liver disease on computed tomography in patients with inflammatory bowel disease visiting an emergency department","volume":"32","author":"Likhitsup","year":"2019","journal-title":"Ann Gastroenterol"},{"key":"2024030118332374800_CIT0102","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/ibd\/izy200","article-title":"Screening for nonalcoholic fatty liver disease in inflammatory bowel diseases: a cohort study using transient elastography","volume":"25","author":"Saroli Palumbo","year":"2019","journal-title":"Inflamm Bowel Dis"},{"key":"2024030118332374800_CIT0103","doi-asserted-by":"crossref","first-page":"107","DOI":"10.23736\/S0026-4806.19.06389-4","article-title":"Autoimmune diseases in first- And second-degree relatives of patients with inflammatory bowel diseases: a case-control survey in Israel","volume":"111","author":"Mari","year":"2020","journal-title":"Minerva Med"},{"key":"2024030118332374800_CIT0104","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1038\/s41390-019-0702-3","article-title":"Comorbidities in adolescents with inflammatory bowel disease: findings from a population-based cohort study","volume":"87","author":"Ghersin","year":"2020","journal-title":"Pediatr Res"},{"key":"2024030118332374800_CIT0105","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1093\/ibd\/izaa019","article-title":"Comparison of disease phenotypes and clinical characteristics among south Asian and white patients with inflammatory bowel disease at a tertiary referral center","volume":"26","author":"Bodiwala","year":"2020","journal-title":"Inflamm Bowel Dis"},{"key":"2024030118332374800_CIT0106","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1093\/ibd\/izz324","article-title":"Derivation and internal validation of a clinical prediction tool to predict nonalcoholic fatty liver disease in patients with Crohn\u2019s disease","volume":"26","author":"McHenry","year":"2020","journal-title":"Inflamm Bowel Dis"},{"key":"2024030118332374800_CIT0107","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1053\/j.gastro.2020.05.049","article-title":"Effects of primary sclerosing cholangitis on risks of cancer and death in people with inflammatory bowel disease, based on sex, race, and age","volume":"159","author":"Trivedi","year":"2020","journal-title":"Gastroenterology"},{"key":"2024030118332374800_CIT0108","first-page":"1","article-title":"Extraintestinal manifestations and other comorbidities in ulcerative colitis and Crohn disease: a Danish nationwide registry study 2003\u20132016","volume":"2","author":"Vadstrup","year":"2020","journal-title":"Crohns Colitis 360"},{"key":"2024030118332374800_CIT0109","doi-asserted-by":"crossref","first-page":"298","DOI":"10.2991\/jegh.k.200330.001","article-title":"Extraintestinal manifestations of inflammatory bowel disease in middle eastern patients","volume":"10","author":"Adam","year":"2020","journal-title":"J Epidemiol Glob Health"},{"key":"2024030118332374800_CIT0110","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4292\/wjgpt.v11.i3.48","article-title":"Hepatobiliary manifestations in children with inflammatory bowel disease: a single-center experience in a low\/middle income country","volume":"11","author":"El-Shabrawi","year":"2020","journal-title":"World J Gastrointest Pharmacol Ther"},{"key":"2024030118332374800_CIT0111","doi-asserted-by":"crossref","first-page":"7528","DOI":"10.3748\/wjg.v26.i47.7528","article-title":"Prevalence and associated factors of obesity in inflammatory bowel disease: a case-control study","volume":"26","author":"Losurdo","year":"2020","journal-title":"World J Gastroenterol"},{"key":"2024030118332374800_CIT0112","doi-asserted-by":"crossref","first-page":"7367","DOI":"10.3748\/wjg.v26.i46.7367","article-title":"Prevalence and risk factors of nonalcoholic fatty liver disease in patients with inflammatory bowel diseases: a cross-sectional and longitudinal analysis","volume":"26","author":"Hoffmann","year":"2020","journal-title":"World J Gastroenterol"},{"key":"2024030118332374800_CIT0113","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1159\/000506938","article-title":"Sarcopenia is a new risk factor of nonalcoholic fatty liver disease in patients with inflammatory bowel disease","volume":"38","author":"Kang","year":"2020","journal-title":"Dig Dis"},{"key":"2024030118332374800_CIT0114","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/SGA.0000000000000461","article-title":"Ulcerative colitis as an independent risk factor for hepatic steatosis","volume":"43","author":"Mancina","year":"2020","journal-title":"Gastroenterol Nurs"},{"key":"2024030118332374800_CIT0115","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1093\/ibd\/izz209","article-title":"Unique phenotypic characteristics and clinical course in patients with ulcerative colitis and primary sclerosing cholangitis: a multicenter US experience","volume":"26","author":"Wang","year":"2020","journal-title":"Inflamm Bowel Dis"},{"key":"2024030118332374800_CIT0116","doi-asserted-by":"crossref","first-page":"e0252286","DOI":"10.1371\/journal.pone.0252286","article-title":"Evaluation of non-alcoholic fatty liver disease in patients with inflammatory bowel disease using controlled attenuation parameter technology: a Taiwanese retrospective cohort study","volume":"16","author":"Yen","year":"2021","journal-title":"PLoS One"},{"key":"2024030118332374800_CIT0117","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1097\/MPG.0000000000003023","article-title":"Evaluation of nonalcoholic fatty liver disease in pediatric patients with inflammatory bowel disease","volume":"72","author":"Cohen","year":"2021","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2024030118332374800_CIT0118","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.dld.2020.06.046","article-title":"Extraintestinal manifestation of inflammatory bowel disease in Asian patients: a multinational study","volume":"53","author":"Park","year":"2021","journal-title":"Dig Liver Dis"},{"key":"2024030118332374800_CIT0119","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1007\/s10620-020-06424-x","article-title":"Extraintestinal manifestations in patients with inflammatory bowel disease: study based on the ENEIDA Registry","volume":"66","author":"Algaba","year":"2021","journal-title":"Dig Dis Sci"},{"key":"2024030118332374800_CIT0120","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1158\/1055-9965.EPI-20-1241","article-title":"Hepatobiliary cancer risk in patients with inflammatory bowel disease: a Scandinavian population-based cohort study","volume":"30","author":"Erichsen","year":"2021","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"2024030118332374800_CIT0121","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ibd\/izaa097","article-title":"Multidimensional impact of Mediterranean diet on IBD patients","volume":"27","author":"Chicco","year":"2021","journal-title":"Inflamm Bowel Dis"},{"key":"2024030118332374800_CIT0122","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1007\/s10620-020-06588-6","article-title":"Nonalcoholic fatty liver disease is common in IBD patients however progression to hepatic fibrosis by noninvasive markers is rare","volume":"66","author":"Ritaccio","year":"2021","journal-title":"Dig Dis Sci"},{"key":"2024030118332374800_CIT0123","doi-asserted-by":"crossref","first-page":"346","DOI":"10.15403\/jgld-3818","article-title":"Risk factors for extraintestinal manifestations in inflammatory bowel diseases-data from the Romanian National Registry","volume":"30","author":"S\u00eengeap","year":"2021","journal-title":"J Gastrointestin Liver Dis"},{"key":"2024030118332374800_CIT0124","doi-asserted-by":"crossref","first-page":"5984","DOI":"10.3390\/jcm10245984","article-title":"Temporal relationship of extraintestinal manifestations in inflammatory bowel disease","volume":"10","author":"Fedor","year":"2021","journal-title":"J Clin Med"},{"key":"2024030118332374800_CIT0125","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s10620-021-06969-5","article-title":"Association between portal vein thrombosis and pouchitis in patients with ulcerative colitis","volume":"67","author":"Syed","year":"2022","journal-title":"Dig Dis Sci"},{"key":"2024030118332374800_CIT0126","doi-asserted-by":"crossref","first-page":"82","DOI":"10.14740\/gr1509","article-title":"Burden and predictors of non-alcoholic fatty liver disease in a retrospective cohort of patients With Crohn\u2019s Disease","volume":"15","author":"Abomhya","year":"2022","journal-title":"Gastroenterology Res"},{"key":"2024030118332374800_CIT0127","doi-asserted-by":"crossref","first-page":"236","DOI":"10.5009\/gnl20337","article-title":"Clinical characteristics and long-term outcomes of pediatric ulcerative colitis: a single-center experience in Korea","volume":"16","author":"Jang","year":"2022","journal-title":"Gut Liver"},{"key":"2024030118332374800_CIT0128","doi-asserted-by":"crossref","first-page":"867293","DOI":"10.3389\/fmed.2022.867293","article-title":"Clinico-epidemiological characteristics of patients with inflammatory bowel disease in Egypt: a nationwide multicenter study","volume":"9","author":"Elbadry","year":"2022","journal-title":"Front Med"},{"key":"2024030118332374800_CIT0129","doi-asserted-by":"crossref","first-page":"103363","DOI":"10.1016\/j.amsu.2022.103363","article-title":"Extraintestinal manifestation of inflammatory bowel disease and associated factors in pediatric patients","volume":"75","author":"Rahmani","year":"2022","journal-title":"Ann Med Surg"},{"key":"2024030118332374800_CIT0130","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.3390\/jcm11092623","article-title":"Hepatic steatosis and fibrosis in chronic inflammatory bowel disease","volume":"11","author":"Veltkamp","year":"2022","journal-title":"J Clin Med"},{"key":"2024030118332374800_CIT0131","doi-asserted-by":"crossref","first-page":"823900","DOI":"10.3389\/fmed.2022.823900","article-title":"Immigrant IBD patients in Spain are younger, have more extraintestinal manifestations and use more biologics than native patients","volume":"9","author":"Guti\u00e9rrez","year":"2022","journal-title":"Front Med"},{"key":"2024030118332374800_CIT0132","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s12876-022-02238-5","article-title":"Prevalence and predictors of non-alcoholic liver disease on MRI among patients with Crohn\u2019s disease","volume":"22","author":"Hong","year":"2022","journal-title":"BMC Gastroenterol"},{"key":"2024030118332374800_CIT0133","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/apt.12794","article-title":"Systematic review: the epidemiology of the hepatobiliary manifestations in patients with inflammatory bowel disease","volume":"40","author":"Gizard","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"2024030118332374800_CIT0134","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1093\/ibd\/izz043","article-title":"Systematic review with meta-analysis: epidemiology of nonalcoholic fatty liver disease in patients with inflammatory bowel disease","volume":"25","author":"Zou","year":"2019","journal-title":"Inflamm Bowel Dis"},{"key":"2024030118332374800_CIT0135","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1093\/ibd\/izaa189","article-title":"Prevalence of nonalcoholic fatty liver disease in patients with inflammatory bowel disease: a systematic review and meta-analysis","volume":"27","author":"Lin","year":"2021","journal-title":"Inflamm Bowel Dis"},{"key":"2024030118332374800_CIT0136","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/apt.16879","article-title":"Prevalence of, and risk factors for, non-alcoholic fatty liver disease in patients with inflammatory bowel disease","volume":"55","author":"Zamani","year":"2022","journal-title":"Aliment Pharmacol Ther"},{"key":"2024030118332374800_CIT0137","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1053\/j.gastro.2021.08.032","article-title":"Prevalence of primary sclerosing cholangitis in patients with inflammatory bowel disease: a systematic review and meta-analysis","volume":"161","author":"Barberio","year":"2021","journal-title":"Gastroenterology"},{"key":"2024030118332374800_CIT0138","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/1751-2980.12286","article-title":"Is gallstone disease associated with inflammatory bowel diseases? a meta-analysis","volume":"16","author":"Zhang","year":"2015","journal-title":"J Dig Dis"},{"key":"2024030118332374800_CIT0139","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.12998\/wjcc.v8.i18.4075","article-title":"Primary sclerosing cholangitis and autoimmune hepatitis overlap syndrome associated with inflammatory bowel disease: a case report and systematic review","volume":"8","author":"Ballotin","year":"2020","journal-title":"World J Clin Cases"},{"key":"2024030118332374800_CIT0140","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1093\/ecco-jcc\/jjw080","article-title":"Amyloidosis in inflammatory bowel disease: a systematic review of epidemiology, clinical features, and treatment","volume":"10","author":"Tosca Cuquerella","year":"2016","journal-title":"J Crohns Colitis"},{"key":"2024030118332374800_CIT0141","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S2468-1253(19)30333-4","article-title":"The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"5","author":"GBD 2017 Inflammatory Bowel Disease Collaborators","year":"2020","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2024030118332374800_CIT0142","doi-asserted-by":"crossref","first-page":"6866","DOI":"10.3748\/wjg.v25.i47.6866","article-title":"Epidemiology of inflammatory bowel disease in South America: a systematic review","volume":"25","author":"Selvaratnam","year":"2019","journal-title":"World J Gastroenterol"},{"key":"2024030118332374800_CIT0143","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1093\/ecco-jcc\/jjab029","article-title":"The burden of inflammatory bowel disease in Europe in 2020","volume":"15","author":"Zhao","year":"2021","journal-title":"J Crohns Colitis"},{"key":"2024030118332374800_CIT0144","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.crohns.2012.04.010","article-title":"The \u2018hygiene hypothesis\u2019 in IBD","volume":"6","author":"Gearry","year":"2012","journal-title":"J Crohns Colitis"},{"key":"2024030118332374800_CIT0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/17474124.2022.2020647","article-title":"COVID-19 and hygiene hypothesis: increment of the inflammatory bowel diseases in next generation","volume":"16","author":"Shahrbaf","year":"2022","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"2024030118332374800_CIT0146","doi-asserted-by":"crossref","first-page":"e742","DOI":"10.3399\/bjgp13X674422","article-title":"The strength of primary care in Europe: an international comparative study","volume":"63","author":"Kringos","year":"2013","journal-title":"Br J Gen Pract"},{"key":"2024030118332374800_CIT0147","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1093\/ecco-jcc\/jjx013","article-title":"The EpiCom survey-registries across europe, epidemiological research and beyond","volume":"11","author":"Gordon","year":"2017","journal-title":"J Crohns Colitis"},{"key":"2024030118332374800_CIT0148","author":"World Bank"},{"key":"2024030118332374800_CIT0149","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S2468-1253(19)30358-9","article-title":"Global burden of inflammatory bowel disease","volume":"5","author":"Jairath","year":"2020","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2024030118332374800_CIT0150","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/ibd\/izab074","article-title":"Trends in U.S. health care spending on inflammatory bowel diseases, 1996-2016","volume":"28","author":"Singh","year":"2022","journal-title":"Inflamm Bowel Dis"},{"key":"2024030118332374800_CIT0151","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41575-020-00360-x","article-title":"The four epidemiological stages in the global evolution of inflammatory bowel disease","volume":"18","author":"Kaplan","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2024030118332374800_CIT0152","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1136\/archdischild-2017-313955","article-title":"Paediatric inflammatory bowel disease: improving early diagnosis","volume":"103","author":"Ashton","year":"2018","journal-title":"Arch Dis Child"},{"key":"2024030118332374800_CIT0153","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1053\/j.gastro.2021.12.282","article-title":"Twenty-first century trends in the global epidemiology of pediatric-onset inflammatory bowel disease: systematic review","volume":"162","author":"Kuenzig","year":"2022","journal-title":"Gastroenterology"},{"key":"2024030118332374800_CIT0154","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/cld.1046","article-title":"Hepatic manifestations of inflammatory bowel disease","volume":"17","author":"Patel","year":"2021","journal-title":"Clinical Liver Disease"},{"key":"2024030118332374800_CIT0155","doi-asserted-by":"crossref","first-page":"319","DOI":"10.4254\/wjh.v14.i2.319","article-title":"Hepatobiliary manifestations in inflammatory bowel disease: a practical approach","volume":"14","author":"N\u00fa\u00f1ez","year":"2022","journal-title":"World J Hepatol"},{"key":"2024030118332374800_CIT0156","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1093\/ibd\/izab199","article-title":"The impact of NAFLD on hospitalization outcomes in patients with inflammatory bowel diseases: nationwide analysis","volume":"28","author":"Noorian","year":"2021","journal-title":"Inflamm Bowel Dis"},{"key":"2024030118332374800_CIT0157","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1053\/j.gastro.2018.08.024","article-title":"Risk of hepatocellular cancer in patients with non-alcoholic fatty liver disease","volume":"155","author":"Kanwal","year":"2018","journal-title":"Gastroenterology"},{"key":"2024030118332374800_CIT0158","doi-asserted-by":"crossref","first-page":"912","DOI":"10.3390\/diagnostics10110912","article-title":"Complications of non-alcoholic fatty liver disease in extrahepatic organs","volume":"10","author":"Tomeno","year":"2020","journal-title":"Diagnostics [Basel]"},{"key":"2024030118332374800_CIT0159","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s12016-019-08764-7","article-title":"Cholangiocarcinoma in patients with primary sclerosing cholangitis (PSC): a comprehensive review","volume":"58","author":"Song","year":"2020","journal-title":"Clin Rev Allergy Immunol"},{"key":"2024030118332374800_CIT0160","first-page":"127","article-title":"Liver transplant in patients with primary sclerosing cholangitis","volume":"12","author":"Goldberg","year":"2016","journal-title":"Gastroenterol Hepatol [N Y]"},{"key":"2024030118332374800_CIT0161","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/MEG.0000000000000576","article-title":"Increased risk of colorectal neoplasia in patients with primary sclerosing cholangitis and inflammatory bowel disease: a meta-analysis of 16 observational studies","volume":"28","author":"Zheng","year":"2016","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2024030118332374800_CIT0162","doi-asserted-by":"crossref","first-page":"4548","DOI":"10.3748\/wjg.v23.i25.4548","article-title":"Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis","volume":"23","author":"Bajer","year":"2017","journal-title":"World J Gastroenterol"},{"key":"2024030118332374800_CIT0163","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/myc.13238","article-title":"Gut mycobiome: the probable determinative role of fungi in IBD patients","volume":"64","author":"Beheshti-Maal","year":"2021","journal-title":"Mycoses"},{"key":"2024030118332374800_CIT0164","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/17474124.2022.2031979","article-title":"PSC associated inflammatory bowel disease: a distinct entity","volume":"16","author":"Beheshti-Maal","year":"2022","journal-title":"Exp Rev Gastroenterol Hepatol"},{"key":"2024030118332374800_CIT0165","first-page":"e26121","article-title":"Prevalence of gallstones in ulcerative colitis and Crohn\u2019s Disease: a systematic review and meta-analysis","volume":"14","author":"Baig","year":"2022","journal-title":"Cureus"},{"key":"2024030118332374800_CIT0166","doi-asserted-by":"crossref","first-page":"564","DOI":"10.3389\/fphys.2020.00564","article-title":"IBD and bile acid absorption: focus on pre-clinical and clinical observations","volume":"11","author":"Fitzpatrick","year":"2020","journal-title":"Front Physiol"},{"key":"2024030118332374800_CIT0167","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.clinre.2011.10.007","article-title":"PSC, AIH and overlap syndrome in inflammatory bowel disease","volume":"36","author":"Trivedi","year":"2012","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"2024030118332374800_CIT0168","doi-asserted-by":"crossref","first-page":"185","DOI":"10.32074\/1591-951X-241","article-title":"Pathology of autoimmune hepatitis","volume":"113","author":"Covelli","year":"2021","journal-title":"Pathologica"},{"key":"2024030118332374800_CIT0169","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12959-015-0044-2","article-title":"Thrombosis in inflammatory bowel diseases: what\u2019s the link","volume":"13","author":"Giannotta","year":"2015","journal-title":"Thromb J"},{"key":"2024030118332374800_CIT0170","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1093\/ibd\/izac189","article-title":"Use of IBD drugs in patients with hepatobiliary comorbidities: tips and tricks","volume":"29","author":"Massironi","year":"2022","journal-title":"Inflamm Bowel Dis"}],"container-title":["Journal of Crohn's and Colitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/advance-article-pdf\/doi\/10.1093\/ecco-jcc\/jjad157\/52191312\/jjad157.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/18\/3\/360\/56814031\/jjad157.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/18\/3\/360\/56814031\/jjad157.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T18:35:04Z","timestamp":1709318104000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article\/18\/3\/360\/7268290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,11]]},"references-count":170,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,9,11]]},"published-print":{"date-parts":[[2024,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ecco-jcc\/jjad157","relation":{},"ISSN":["1873-9946","1876-4479"],"issn-type":[{"value":"1873-9946","type":"print"},{"value":"1876-4479","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3,1]]},"published":{"date-parts":[[2023,9,11]]}}}