{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:59:58Z","timestamp":1793743198509,"version":"4.6.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Although ulcerative proctitis [UP] can dramatically impair quality of life, treatment efficacy has been poorly investigated in UP as it was historically excluded from phase 2\/3 randomised controlled trials in ulcerative colitis. Our aim was to assess the effectiveness and safety of tofacitinib for the treatment of UP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a retrospective, multicentre study in 17 GETAID centres, including consecutive patients with UP treated with tofacitinib. The primary endpoint was steroid-free remission between Week 8 and Week 14, defined as a partial Mayo score of 2 [and no individual subscore above 1]. Secondary outcomes included clinical response and steroid-free remission after induction and at 1 year.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>All the 35 enrolled patients previously received anti-tumour necrosis factor [TNF] therapy and 88.6% were exposed to at least two lines of biologics. At baseline, the median partial Mayo score was 7 (intequartile range [IQR] [5.5-7]). After induction [W8-W14], 42.9% and 60.0% of patients achieved steroid-free remission and clinical response, respectively. At 1 year, the steroid-free clinical remission and clinical response rates were 39.4% and 45.5%, respectively, and 51.2% [17\/33] were still receiving tofacitinib treatment. Survival without tofacitinib withdrawal was estimated at 50.4% (95% confidence interval [CI] [35.5-71.6]) at 1 year. Only a lower partial Mayo at baseline was independently associated with remission at induction (0dds ratio [OR]\u2005=\u20050.56 for an increase of 1, (95% CI [0.33-0.95], p\u2005=\u20050.03). Five [14.3%] adverse events were reported, with one leading to treatment withdrawal [septic shock secondary to cholecystitis].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Tofacitinib may offer a therapeutic option for patients with refractory UP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjad169","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T13:14:55Z","timestamp":1696511695000},"page":"424-430","source":"Crossref","is-referenced-by-count":13,"title":["Tofacitinib for Patients with Anti-TNF Refractory Ulcerative Proctitis: A Multicentre Cohort Study from the GETAID"],"prefix":"10.1093","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7761-2879","authenticated-orcid":false,"given":"Mathieu","family":"Uzzan","sequence":"first","affiliation":[{"name":"University of Lille, CHU Lille, Institute for Translational Research in Inflammation , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Nachury","sequence":"additional","affiliation":[{"name":"University of Lille, CHU Lille, Institute for Translational Research in Inflammation , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Nuzzo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hopital Beaujon , Universite de Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Amiot","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hopitaux Universitaires Bic\u00eatre, Universite Paris Est Creteil and Universite Paris Saclay, Centre for Research in Epidemiology and Population Health , Le Kremlin Bic\u00eatre , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Caron","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nancy University Hospital, and INSERM, NGERE, University of Lorraine , Nancy , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Benezech","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Centre Hospitalier Avignon , Avignon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6347-409X","authenticated-orcid":false,"given":"Anthony","family":"Buisson","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne, Service d\u2019H\u00e9pato-Gastroent\u00e9rologie , Clermont-Ferrand , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Bouguen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, CHU Renes , Renes , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Le Berre","sequence":"additional","affiliation":[{"name":"Institut des Maladies de l\u2019Appareil Digestif, H\u00e9pato-Gastro-Ent\u00e9rologie et Assistance Nutritionnelle,Nantes Universit\u00e9 , Nantes , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5490-4350","authenticated-orcid":false,"given":"Catherine","family":"Reenaers","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, CHU Li\u00e8ge, University of Li\u00e8ge , Li\u00e8ge , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Le Cosquer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Pancreatology, H\u00f4pital Rangueil, Universit\u00e9 Toulouse Paul Sabatier , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Savoye","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Rouen University Hospital, UMR 1073 University of Rouen Normandy , Rouen , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maeva","family":"Charkaoui","sequence":"additional","affiliation":[{"name":"Department of Hepatogastroenterology, Dijon University Hospital , Dijon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Vidon","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology. Hopital Intercommunal de Cr\u00e9teil , Cr\u00e9teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Guillo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital of Marseille Nord, University of Aix-Marseille , Marseille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2337-2902","authenticated-orcid":false,"given":"Mathurin","family":"Fumery","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Amiens University Hospital, and UMR I01, PERITOX, Jules Verne University of Picardy , Amiens , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Peyrin-Biroulet","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nancy University Hospital, and INSERM, NGERE, University of Lorraine , Nancy , 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