{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:29:17Z","timestamp":1790785757483,"version":"4.1.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Inflammatory bowel disease [IBD] is associated with an increased risk of developing lymphoma. Although recent data have clarified the epidemiology of lymphoma in IBD patients, the clinical and pathological characteristics of lymphoma in IBD remain poorly known.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients with IBD and lymphoma were retrospectively identified in the framework of a national collaborative study including the Groupe d\u2019\u00c9tude Th\u00e9rapeutique des Affections Inflammatoires du Tube Digestif [GETAID] and the Lymphoma Study Association [LYSA]. We characterized clinical and prognostic features for the three most frequent lymphoma subtypes occurring in IBD. We performed a multicentre case-control study. Controls [lymphoma de novo] were matched [5:1] to cases on gender, age at diagnosis, lymphoma subtype, year of diagnosis, and IPI\/FLIPI indexes. Overall survival and progression-free survival were compared between cases and controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 133 IBD patients with lymphoma were included [males\u2005=\u200562.4%, median age at lymphoma diagnosis\u2005=\u200549 years in males; 42 years in females]. Most had Crohn\u2019s disease [73.7%] and were exposed to thiopurines [59.4%]. The most frequent lymphoma subtypes were diffuse large B cell lymphoma [DLBCL, 45.1%], Hodgkin lymphoma [HL, 18.8%], and follicular lymphoma [FL, 10.5%]. When matched with 365 controls, prognosis was improved in IBD patients with DLBCL compared to controls [p\u2005=\u20050.0064, hazard ratio\u2005=\u20050.36] or similar [HL and FL].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Lymphomas occurring in IBD patients do not seem to have a worse outcome than in patients without IBD. Due to the rarity of this situation, such patients should be managed in expert centres.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjad177","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T10:54:22Z","timestamp":1697626462000},"page":"533-539","source":"Crossref","is-referenced-by-count":3,"title":["Lymphoma in Patients with Inflammatory Bowel Disease: A Multicentre Collaborative Study Between GETAID and LYSA"],"prefix":"10.1093","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6412-932X","authenticated-orcid":false,"given":"Marie","family":"Muller","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Nancy University Hospital, University of Lorraine , Nancy , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Bros\u00e9us","sequence":"additional","affiliation":[{"name":"University of Lorraine, Inserm U1256 \u00ab Nutrition \u2013 Genetics and exposure to environmental risks - NGERE \u00bb , F-54000, Nancy , France"},{"name":"University of Lorraine, CHRU-Nancy Hematology Laboratory, Laboratory Department , F-54000 Nancy , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Guilloteau","sequence":"additional","affiliation":[{"name":"Registre des hemopathies Malignes de C\u00f4te d\u2019Or, Inserm U1231, University of Burgundy and Dijon University Hospital , Dijon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Wasse","sequence":"additional","affiliation":[{"name":"Registre des hemopathies Malignes de C\u00f4te d\u2019Or, Inserm U1231, University of Burgundy and Dijon University Hospital , Dijon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Thi\u00e9blemont","sequence":"additional","affiliation":[{"name":"AP-HP, Saint-Louis Hospital, Hemato-oncology, University of Paris , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Nancey","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Claude Bernard Lyon 1, Hospices Civils de Lyon , CHU Lyon-Sud, Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Cadiot","sequence":"additional","affiliation":[{"name":"Department of Hepato-Gastro-Enterology, Reims University Hospital , Reims , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Amiot","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Henri Mondor University Hospital, AP-HP, Paris Est Cr\u00e9teil University , Cr\u00e9teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Laharie","sequence":"additional","affiliation":[{"name":"Department of Hepato-Gastro-Enterology, Bordeaux University Hospital , Pessac , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1859-7146","authenticated-orcid":false,"given":"Sophie","family":"Vieujean","sequence":"additional","affiliation":[{"name":"Department of Hepato-Gastroenterology, University Hospital CHU of Li\u00e8ge , Li\u00e8ge , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoram","family":"Bouhnik","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et Recherche M\u00e9dicale et Universit\u00e9 Paris Diderot, Paris H\u00f4pital Beaujon , AP-HP, Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00e9","family":"Martineau","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, H\u00f4pital Europ\u00e9en George Pompidou , AP-HP, Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Michiels","sequence":"additional","affiliation":[{"name":"Department of Hepato-Gastro-Enterology, Dijon University Hospital , Dijon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Hebuterne","sequence":"additional","affiliation":[{"name":"Department of Hepato-Gastro-Enterology, Nice University Hospital , Nice , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Savoye","sequence":"additional","affiliation":[{"name":"Department of Hepato-Gastro-Enterology, Rouen University Hospital , Rouen , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Franchimont","sequence":"additional","affiliation":[{"name":"Department of Hepato-Gastro-Enterology, Erasme University Hospital , Brussels , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Seksik","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique, AP-HP, H\u00f4pital Saint-Antoine, Department of Gastroenterology , F75012, Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Beaugerie","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique, AP-HP, H\u00f4pital Saint-Antoine, Department of Gastroenterology , F75012, Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Maynadi\u00e9","sequence":"additional","affiliation":[{"name":"Registre des hemopathies Malignes de C\u00f4te d\u2019Or, Inserm U1231, University of Burgundy and Dijon University Hospital , Dijon , 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