{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:36:21Z","timestamp":1792841781715,"version":"4.5.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 DK062413"],"award-info":[{"award-number":["U01 DK062413"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Multiple factors are suggested to place Crohn\u2019s disease patients at risk of recurrence after ileocolic resection with conflicting associations. We aimed to identify clinical predictors of recurrence at first [early] and further [late] postoperative colonoscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Crohn\u2019s disease patients undergoing ileocolic resection were prospectively recruited at six North American centres. Clinical data were collected and endoscopic recurrence was defined as Rutgeerts score \u2265i2. A multivariable model was fitted to analyse variables independently associated with recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 365 patients undergoing 674 postoperative colonoscopies were included with a median age of 32 years, 189 [51.8%] were male, and 37 [10.1%] were non-Whites. Postoperatively, 133 [36.4%] used anti-tumour necrosis factor [anti-TNF] and 30 [8.2%] were smokers. At first colonoscopy, 109 [29.9%] had recurrence. Male gender (odds ratio [OR]\u2005=\u20051.95, 95% confidence interval [CI] 1.12\u20133.40), non-White ethnicity [OR\u2005=\u20052.48, 95% CI 1.09\u20135.63], longer interval between surgery and colonoscopy [OR\u2005=\u20051.09, 95% CI 1.002\u20131.18], and postoperative smoking [OR\u2005=\u20052.78, 95% CI 1.16\u20136.67] were associated with recurrence, while prophylactic anti-TNF reduced the risk [OR\u2005=\u20050.28, 95% CI 0.14\u20130.55]. Postoperative anti-TNF prophylaxis had a protective effect on anti-TNF experienced patients but not on anti-TNF na\u00efve patients. Among patients without recurrence at first colonoscopy, Rutgeerts score i1 was associated with subsequent recurrence [OR\u2005=\u20054.43, 95% CI 1.73\u201311.35].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We identified independent clinical predictors of early and late Crohn\u2019s disease postoperative endoscopic recurrence. Clinical factors traditionally used for risk stratification failed to predict recurrence and need to be revised.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjad186","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T13:32:25Z","timestamp":1700227945000},"page":"615-627","source":"Crossref","is-referenced-by-count":26,"title":["Clinical Predictors of Early and Late Endoscopic Recurrence Following Ileocolonic Resection in Crohn\u2019s Disease"],"prefix":"10.1093","volume":"18","author":[{"given":"Cristian","family":"Hern\u00e1ndez-Rocha","sequence":"first","affiliation":[{"name":"Zane Cohen Centre for Digestive Diseases, Lunenfeld-Tanenbaum Research Institute, Sinai Health System , Toronto, Ontario , Canada"},{"name":"Division of Gastroenterology, Mount Sinai Hospital, Sinai Health System, University of Toronto , Toronto, Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Walshe","sequence":"additional","affiliation":[{"name":"Zane Cohen Centre for Digestive Diseases, Lunenfeld-Tanenbaum Research Institute, Sinai Health System , Toronto, Ontario , Canada"},{"name":"Division of Gastroenterology, Mount Sinai Hospital, Sinai Health System, University of Toronto , Toronto, Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sondra","family":"Birch","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, University of Chicago , Chicago, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ksenija","family":"Sabic","sequence":"additional","affiliation":[{"name":"The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai , New York, NY , USA"},{"name":"Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ujunwa","family":"Korie","sequence":"additional","affiliation":[{"name":"The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai , New York, NY , USA"},{"name":"Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Chasteau","sequence":"additional","affiliation":[{"name":"Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vessela M","family":"Miladinova","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh , Pittsburgh, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B","family":"Sabol","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh , Pittsburgh, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emebet","family":"Mengesha","sequence":"additional","affiliation":[{"name":"F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center , Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Hanna","sequence":"additional","affiliation":[{"name":"F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center , Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeriya","family":"Pozdnyakova","sequence":"additional","affiliation":[{"name":"F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center , Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Johns Hopkins Medical Institutions , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Kohen","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Centre, Division of Gastroenterology, McGill University Health Centre , Montr\u00e9al, Quebec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Milgrom","sequence":"additional","affiliation":[{"name":"Zane Cohen Centre for Digestive Diseases, Lunenfeld-Tanenbaum Research Institute, Sinai Health System , Toronto, Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne M","family":"Stempak","sequence":"additional","affiliation":[{"name":"Zane Cohen Centre for Digestive Diseases, Lunenfeld-Tanenbaum Research Institute, Sinai Health System , Toronto, Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Bitton","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Centre, Division of Gastroenterology, McGill University Health Centre , Montr\u00e9al, Quebec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R","family":"Brant","sequence":"additional","affiliation":[{"name":"Crohn\u2019s and Colitis Center of New Jersey, Division of Gastroenterology and Hepatology, Department of Medicine, Rutgers Robert Wood Johnson Medical School , New Brunswick, NJ , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D","family":"Rioux","sequence":"additional","affiliation":[{"name":"Research Centre, Montreal Heart Institute , Montr\u00e9al, Quebec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dermot P B","family":"McGovern","sequence":"additional","affiliation":[{"name":"F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center , Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard H","family":"Duerr","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh , Pittsburgh, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy H","family":"Cho","sequence":"additional","affiliation":[{"name":"The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai , New York, NY , USA"},{"name":"Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil L","family":"Schumm","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, University of Chicago , Chicago, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S","family":"Silverberg","sequence":"additional","affiliation":[{"name":"Zane Cohen Centre for Digestive Diseases, Lunenfeld-Tanenbaum Research Institute, Sinai Health System , Toronto, Ontario , Canada"},{"name":"Division of Gastroenterology, Mount Sinai Hospital, Sinai Health System, University of Toronto , Toronto, Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Lazarev","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Johns Hopkins Medical Institutions , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,17]]},"reference":[{"key":"2024042313294008400_CIT0001","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1053\/j.gastro.2011.01.055","article-title":"Epidemiology and natural history of inflammatory bowel 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