{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T18:42:43Z","timestamp":1773513763393,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>An appendectomy for appendiceal inflammation has been suggested to ameliorate the clinical course of patients with ulcerative colitis [UC]. In contrast, for Crohn\u2019s disease [CD] an inverse association has been suggested with a higher incidence of CD and worse prognosis after appendectomy. The aim of this study was to analyse the clinical relevance of an inflamed appendix in CD patients undergoing ileocaecal resection [ICR].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>All consecutive patients undergoing primary ICR between 2007 and 2018 were considered for inclusion. Microscopic data of available appendiceal resection specimens [n\u2005=\u200599] were revised by a dedicated inflammatory bowel disease [IBD] pathologist and scored as inflamed or not inflamed. Eighteen patients had a previous appendectomy. Pathological findings were correlated with disease characteristics and recurrence rates [clinical, endoscopic, and intervention-related].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total 117 patients were included, 77 [65.8%] females, with a median age of 30 years (interquartile range [IQR] 24\u201343), and a median follow up of 102 months [IQR 76\u2013114]. Of patients without previous appendectomy [n\u2005=\u200599], 39% had an inflamed appendix. No significant differences in disease characteristics [eg, disease location, behaviour, time to surgery] or prognosis could be demonstrated between the two groups. In contrast, previous appendectomy [n\u2005=\u200518] was associated with penetrating disease and numerically shorter disease duration at the time of resection. Furthermore, a trend was seen towards a stronger association with postoperative recurrence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The current study could not confirm a different prognosis for CD patients with and without an inflamed appendix. In contrast, in patients with a previous appendectomy, a trend was seen towards increased postoperative recurrence, which might be related to the higher incidence of penetrating disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjad202","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T20:33:01Z","timestamp":1701462781000},"page":"812-817","source":"Crossref","is-referenced-by-count":6,"title":["The Clinical Relevance of an Inflamed Appendix in Crohn\u2019s Disease"],"prefix":"10.1093","volume":"18","author":[{"given":"Eline M L","family":"van der Does de Willebois","sequence":"first","affiliation":[{"name":"Department of Surgery, Amsterdam University Medical Center , AMC, Amsterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cagla","family":"Sari","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam University Medical Center , AMC, Amsterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aart","family":"Mookhoek","sequence":"additional","affiliation":[{"name":"Institute of Tissue Medicine and Pathology, University of Bern , Bern , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Joustra","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam University Medical Center , AMC, Amsterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"van Dieren","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam University Medical Center , AMC, Amsterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geert R","family":"D\u2019Haens","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam University Medical Center , AMC, Amsterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem A","family":"Bemelman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam University Medical Center , AMC, Amsterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9425-8683","authenticated-orcid":false,"given":"Christianne J","family":"Buskens","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam University Medical Center , AMC, Amsterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,12,1]]},"reference":[{"key":"2024060402061834100_CIT0001","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1046\/j.1365-2567.2003.01700.x","article-title":"Human secretory immunoglobulin A may contribute to biofilm formation in the gut","volume":"109","author":"Bollinger","year":"2003","journal-title":"Immunology"},{"key":"2024060402061834100_CIT0002","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/codi.15184","article-title":"A nationwide database study on colectomy and colorectal cancer in ulcerative colitis: what is the role of appendectomy","volume":"23","author":"Stellingwerf","year":"2021","journal-title":"Colorectal Dis"},{"key":"2024060402061834100_CIT0003","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1038\/ajg.2009.388","article-title":"Appendicectomy as a therapy for ulcerative proctitis","volume":"104","author":"Bolin","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"2024060402061834100_CIT0004","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/ajg.2015.301","article-title":"The Link between the appendix and ulcerative colitis: clinical relevance and potential immunological mechanisms","volume":"111","author":"Sahami","year":"2016","journal-title":"Am J Gastroenterol"},{"key":"2024060402061834100_CIT0005","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1002\/ueg2.12171","article-title":"High prevalence of ulcerative appendicitis in patients with ulcerative colitis","volume":"9","author":"Heuthorst","year":"2021","journal-title":"United European Gastroenterol J"},{"key":"2024060402061834100_CIT0006","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jcol.2017.12.004","article-title":"Appendectomy and Crohn\u2019s disease","volume":"39","author":"Loureiro","year":"2019","journal-title":"J Coloproctol"},{"key":"2024060402061834100_CIT0007","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1111\/j.1572-0241.2008.02118.x","article-title":"The risk of developing Crohn\u2019s disease after an appendectomy: a meta-analysis","volume":"103","author":"Kaplan","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"2024060402061834100_CIT0008","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/ajg.2009.579","article-title":"The natural history of adult Crohn\u2019s disease in population-based cohorts","volume":"105","author":"Peyrin-Biroulet","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"2024060402061834100_CIT0009","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/ecco-jcc\/jjw169","article-title":"rd European evidence-based consensus on the diagnosis and management of Crohn\u2019s disease: Part 2: surgical management and special situations","volume":"11","author":"Gionchetti","year":"2017","journal-title":"J Crohns Colitis"},{"key":"2024060402061834100_CIT0010","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1002\/bjs.10595","article-title":"Short- and medium-term outcomes following primary ileocaecal resection for Crohn\u2019s disease in two specialist centres","volume":"104","author":"de Buck van Overstraeten","year":"2017","journal-title":"Br J Surg"},{"key":"2024060402061834100_CIT0011","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1093\/ibd\/izz290","article-title":"The predictive value of inflammation at ileocecal resection margins for postoperative Crohn\u2019s recurrence: a cohort study","volume":"26","author":"Wasmann","year":"2020","journal-title":"Inflamm Bowel Dis"},{"key":"2024060402061834100_CIT0012","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1463-1318.2005.00903.x","article-title":"A comparison of segmental vs subtotal\/total colectomy for colonic Crohn\u2019s disease: a meta-analysis","volume":"8","author":"Tekkis","year":"2006","journal-title":"Colorectal Dis"},{"key":"2024060402061834100_CIT0013","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00384-018-2995-9","article-title":"Surgical recurrence in Crohn\u2019s disease: a comparison between different types of bowel resections","volume":"33","author":"Aaltonen","year":"2018","journal-title":"Int J Colorectal Dis"},{"key":"2024060402061834100_CIT0014","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.ijsu.2014.07.013","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology [STROBE] Statement: guidelines for reporting observational studies","volume":"12","author":"von Elm","year":"2014","journal-title":"Int J Surg"},{"key":"2024060402061834100_CIT0015","doi-asserted-by":"crossref","first-page":"e555","DOI":"10.1097\/MEG.0000000000002145","article-title":"Changes in disease behaviour and location and factor analysis in patients with Crohn\u2019s disease undergoing repeated resections","volume":"33","author":"Li","year":"2021","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2024060402061834100_CIT0016","volume-title":"Anatomy, Abdomen and Pelvis","author":"Hodge","year":"2023"},{"key":"2024060402061834100_CIT0017","first-page":"540","article-title":"The aetiology of appendicitis","volume":"39","author":"Larner","year":"1988","journal-title":"Br J Hosp Med"},{"key":"2024060402061834100_CIT0018","first-page":"63","article-title":"Obstruction of appendix vermiformis causing acute appendicitis an experimental study in the rabbit","volume":"148","author":"Pieper","year":"1982","journal-title":"Acta Chir Scand"},{"key":"2024060402061834100_CIT0019","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/S0140-6736(15)00275-5","article-title":"Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management","volume":"386","author":"Bhangu","year":"2015","journal-title":"Lancet"},{"key":"2024060402061834100_CIT0020","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1001\/jama.1932.02740680019005","article-title":"Regional ileitis: a pathologic and clinical entity","volume":"99","author":"Crohn","year":"1932","journal-title":"JAMA"},{"key":"2024060402061834100_CIT0021","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1055\/s-0042-1743589","article-title":"Role of the mesentery in Crohn\u2019s terminal ileitis","volume":"35","author":"Becker","year":"2022","journal-title":"Clin Colon Rectal Surg"},{"key":"2024060402061834100_CIT0022","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S2468-1253(21)00179-5","article-title":"Update on the mesentery: structure, function, and role in disease","volume":"7","author":"Coffey","year":"2022","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2024060402061834100_CIT0023","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1053\/gast.2003.50021","article-title":"Appendectomy is followed by increased risk of Crohn\u2019s disease","volume":"124","author":"Andersson","year":"2003","journal-title":"Gastroenterology"},{"key":"2024060402061834100_CIT0024","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1007\/s00268-012-1749-z","article-title":"Examining a common disease with unknown etiology: trends in epidemiology and surgical management of appendicitis in California, 1995-2009","volume":"36","author":"Anderson","year":"2012","journal-title":"World J Surg"},{"key":"2024060402061834100_CIT0025","doi-asserted-by":"crossref","first-page":"693","DOI":"10.4240\/wjgs.v8.i10.693","article-title":"Acute appendicitis: epidemiology, treatment and outcomes: analysis of 16544 consecutive cases","volume":"8","author":"Ceresoli","year":"2016","journal-title":"World J Gastrointest Surg"}],"container-title":["Journal of Crohn's and Colitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/advance-article-pdf\/doi\/10.1093\/ecco-jcc\/jjad202\/54463321\/jjad202.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/18\/6\/812\/58069537\/jjad202.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/18\/6\/812\/58069537\/jjad202.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T02:06:57Z","timestamp":1717466817000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article\/18\/6\/812\/7457535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,1]]},"references-count":25,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,12,1]]},"published-print":{"date-parts":[[2024,6,3]]}},"URL":"https:\/\/doi.org\/10.1093\/ecco-jcc\/jjad202","relation":{},"ISSN":["1873-9946","1876-4479"],"issn-type":[{"value":"1873-9946","type":"print"},{"value":"1876-4479","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,6,1]]},"published":{"date-parts":[[2023,12,1]]}}}