{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:24:59Z","timestamp":1793262299403,"version":"4.5.0"},"reference-count":87,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>In this systematic review we summarise existing scoring indices for assessing disease activity and quality of life in perianal fistulising Crohn\u2019s disease [PFCD], and highlight gaps in the literature.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>MEDLINE, EMBASE, and CENTRAL were searched from August 24, 2022, to identify studies evaluating clinical, radiological, or patient-reported outcome measures [PROMS] in PFCD. The primary objective was to identify all available scoring indices and describe the operating properties of these indices.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 53 studies reported on the use of one clinical index [Perianal Disease Activity Index: PDAI], three PROMs, and 10 radiological indices; 25 studies evaluated the operating properties of these indices. The PDAI demonstrated content validity, construct validity, and responsiveness but criterion validity or reliability were not assessed. The Van Assche Index [VAI], modified VAI, and the Magnetic Resonance Index for Assessing Fistulas in Patients with CD [MAGNIFI-CD] were the most studied radiological indices. These indices demonstrated responsiveness and reliability. The VAI and MAGNIFI-CD demonstrated construct validity; criterion and content validity and feasibility have not been assessed. Among the three PROMs, the Crohn\u2019s Anal Fistula Quality of Life index demonstrated content and construct validity, inter-observer reliability, and responsiveness; criterion validity, intra-observer reliability, and feasibility have not been assessed for this index.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>There are no fully valid, reliable, and responsive clinical disease or radiological indices for PFCD. Although the radiological indices demonstrated responsiveness and reliability, well-defined cut-offs for response and remission are lacking. Future research should focus on establishing standardised definitions and thresholds for outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjad214","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T15:00:53Z","timestamp":1703170853000},"page":"836-850","source":"Crossref","is-referenced-by-count":29,"title":["Scoring Indices for Perianal Fistulising Crohn\u2019s Disease: A Systematic Review"],"prefix":"10.1093","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8281-3237","authenticated-orcid":false,"given":"Sudheer K","family":"Vuyyuru","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology, Schulich school of Medicine, Western University , London, ON , Canada"},{"name":"Alimentiv Inc. , 100 Dundas street, London, ON , 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University of Ljubljana, Department of Gastroenterology, University Medical Center Ljubljana , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K","family":"Macdonald","sequence":"additional","affiliation":[{"name":"Alimentiv Inc. , 100 Dundas street, London, ON , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7341-1351","authenticated-orcid":false,"given":"Silvio","family":"Danese","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele and University Vita-Salute San Raffaele , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Peyrin Biroulet","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nancy University Hospital , Vand\u0153uvre-l\u00e8s-Nancy , France"},{"name":"Inserm, NGERE, University of Lorraine , Nancy , France"},{"name":"INFINY Institute, Nancy University Hospital , Vand\u0153uvre-l\u00e8s-Nancy , France"},{"name":"FHU-CURE, Nancy University Hospital , Vand\u0153uvre-l\u00e8s-Nancy , France"},{"name":"Groupe Hospitalier Priv\u00e9 Ambroise Par\u00e9 - Hartmann, Paris IBD Center , Neuilly sur Seine , France"},{"name":"Division of Gastroenterology and Hepatology, McGill University Health Centre , Montreal, QC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4698-9948","authenticated-orcid":false,"given":"Christopher","family":"Ma","sequence":"additional","affiliation":[{"name":"Alimentiv Inc. , 100 Dundas street, London, ON , Canada"},{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, University of Calgary , Calgary, AB , Canada"},{"name":"Department of Community Health Sciences, Cumming School of Medicine, University of Calgary , Calgary, AB , 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