{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T23:42:04Z","timestamp":1778024524463,"version":"3.51.4"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T00:00:00Z","timestamp":1705881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270543"],"award-info":[{"award-number":["82270543"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170573"],"award-info":[{"award-number":["82170573"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Project of Jinling Hospital","award":["22LCZLXJS28"],"award-info":[{"award-number":["22LCZLXJS28"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Azathioprine [AZA] effectively prevents postoperative endoscopic recurrence [ER] in Crohn\u2019s disease [CD]. However, the efficacy of AZA emerges after 3 months. Exclusive enteral nutrition [EEN] can maintain remission in CD. The present trial investigates whether AZA plus postoperative 3-month EEN is superior to AZA alone in preventing ER of CD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In total, 84 high-risk CD patients undergoing intestinal resection received AZA alone or AZA plus 3 months of EEN [AZA\u2005+\u2005EEN] postoperatively. The primary endpoint was the rate of ER at 12 months. Secondary endpoints included the rate of ER at 3 months, clinical recurrence [CR], CD activity index [CDAI] scores, faecal calprotectin [FC], and C-reactive protein [CRP]. Quality of life was assessed using Short Form-36 [SF-36] and the Inflammatory Bowel Disease Questionnaire [IBDQ].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients in the AZA\u2005+\u2005EEN group exhibited significantly lower rates of ER compared to the AZA group at both 12 months (33.3% [13\/39] vs 63.2% [24\/38], P\u2005=\u20050.009) and 3 months (8.6% [3\/35] vs 28.1% [9\/32], P\u2005=\u20050.037) post-surgery. The rates of CR between the two groups at 3 and 12 months were similar. CDAI scores, FC, albumin level, and CRP were all comparable between the two groups. Quality of life was significantly higher in the AZA group than in the AZA\u2005+\u2005EEN group at 3 months but became comparable from 5 to 12 months postoperatively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In high-risk CD patients, combining AZA with postoperative 3-month EEN reduces 1-year ER but may temporarily impact quality of life. Further large-scale, long-term studies are warranted.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial Number<\/jats:title>\n                  <jats:p>NCT05214430.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjae015","type":"journal-article","created":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T04:20:08Z","timestamp":1705724408000},"page":"1113-1121","source":"Crossref","is-referenced-by-count":11,"title":["Azathioprine Plus Exclusive Enteral Nutrition Versus Azathioprine Monotherapy for the Prevention of Postoperative Recurrence in Patients with Crohn\u2019s Disease: An Open-Label, Single-Centre, Randomized Controlled Trial"],"prefix":"10.1093","volume":"18","author":[{"given":"Ming","family":"Duan","sequence":"first","affiliation":[{"name":"Department of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing 210002 , 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Medical School , Nanjing 210002 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxiu","family":"Liu","sequence":"additional","affiliation":[{"name":"Data and Statistics Division, Department of Critical Care Medicine, Jinling Hospital, Nanjing Medical University , Nanjing 210002 , China"},{"name":"Department of Biostatistics, School of Public Health, Southern Medical University , Guangzhou, Guangdong 510515 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing 210002 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiming","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Colorectal and Proctology, Affiliated Hospital of Nanjing University of Chinese Medicine , Nanjing 210023 , 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