{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T11:15:19Z","timestamp":1772795719968,"version":"3.50.1"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","award":["12A7822N"],"award-info":[{"award-number":["12A7822N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>Disability, an important aspect of disease burden in patients with inflammatory bowel disease [IBD], has been suggested as a valuable clinical endpoint. We aimed to investigate how disease acceptance and perceived control, two psychological predictors of subjective health, are associated with IBD-related disability.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this cross-sectional study, adult IBD patients from the University Hospitals Leuven received a survey with questions about clinical and demographic characteristics, disease acceptance and perceived control [Subjective Health Experience model questionnaire], and IBD-related disability [IBD Disk]. Multiple linear regressions assessed predictors of IBD-related disability in the total sample and in the subgroups of patients in clinical remission or with active disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In the total sample (N\u2005=\u20051250, 54.2% female, median [interquartile range: IQR] age 51 [39\u201361] years, 61.3% Crohn\u2019s disease, 34.9% active disease), adding the psychological predictors to the model resulted in an increased explained variance in IBD-related disability of 19% compared with a model with only demographic and clinical characteristics [R2adj 38% vs 19%, p\u2005&amp;lt;0.001]. The increase in explained variance was higher for patients in clinical remission [\u0394R2adj 20%, p\u2005&amp;lt;0.001] compared with patients with active disease [\u0394R2adj 10%, p\u2005&amp;lt;0.001]. Of these predictors, disease acceptance was most strongly associated with disability in the total sample [\u03b2\u2005=\u2005-0.44, p\u2005&amp;lt;0.001], as well as in both subgroups [\u03b2\u2005=\u2005-0.47, p\u2005&amp;lt;0.001 and \u03b2\u2005=\u2005-0.31, p\u2005&amp;lt;0.001 respectively]. Perceived control was not significantly associated with disability when accounting for all other predictors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Disease acceptance is strongly associated with IBD-related disability, supporting further research into disease acceptance as a treatment target.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjae025","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T17:13:44Z","timestamp":1709745224000},"page":"1025-1033","source":"Crossref","is-referenced-by-count":4,"title":["Disease Acceptance, but not Perceived Control, is Uniquely Associated with Inflammatory Bowel Disease-related Disability"],"prefix":"10.1093","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5373-4989","authenticated-orcid":false,"given":"Anouk","family":"Teugels","sequence":"first","affiliation":[{"name":"Research Group Health Psychology, KU Leuven , Leuven , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilse","family":"van den Eijnden","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, KU Leuven , Leuven , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bep","family":"Keersmaekers","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospitals Leuven , Leuven , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3898-7093","authenticated-orcid":false,"given":"Bram","family":"Verstockt","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospitals Leuven , Leuven , Belgium"},{"name":"Translational Research in Gastrointestinal Disorders, Department of Chronic Diseases and Metabolism, KU Leuven , Leuven , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Sabino","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospitals Leuven , Leuven , Belgium"},{"name":"Translational Research in Gastrointestinal Disorders, Department of Chronic Diseases and Metabolism, KU Leuven , Leuven , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9942-3019","authenticated-orcid":false,"given":"S\u00e9verine","family":"Vermeire","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospitals Leuven , Leuven , Belgium"},{"name":"Translational Research in Gastrointestinal Disorders, Department of Chronic Diseases and Metabolism, KU Leuven , Leuven , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2925-3955","authenticated-orcid":false,"given":"Livia","family":"Guadagnoli","sequence":"additional","affiliation":[{"name":"Laboratory for Brain-Gut Axis Studies, Translational Research Center for Gastrointestinal Disorders, KU Leuven , Leuven , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0048-774X","authenticated-orcid":false,"given":"Ilse","family":"Van Diest","sequence":"additional","affiliation":[{"name":"Research Group Health Psychology, KU Leuven , Leuven , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1492-0716","authenticated-orcid":false,"given":"Marc","family":"Ferrante","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospitals Leuven , Leuven , Belgium"},{"name":"Translational Research in 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