{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:03:02Z","timestamp":1794045782907,"version":"4.8.0"},"reference-count":383,"publisher":"Oxford University Press (OUP)","issue":"8","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03DE029258 and R56DK131277"],"award-info":[{"award-number":["R03DE029258 and R56DK131277"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010393","name":"University of Maryland School of Dentistry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010393","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Johns Hopkins School of Medicine to C.L.S"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>As the opposite ends of the orodigestive tract, the oral cavity and the intestine share anatomical, microbial, and immunological ties that have bidirectional health implications. A growing body of evidence suggests an interconnection between oral pathologies and inflammatory bowel disease [IBD], implying a shift from the traditional concept of independent diseases to a complex, reciprocal cycle. This review outlines the evidence supporting an \u2018oral\u2013gut\u2019 axis, marked by a higher prevalence of periodontitis and other oral conditions in IBD patients and vice versa. We present an in-depth examination of the interconnection between oral pathologies and IBD, highlighting the shared microbiological and immunological pathways, and proposing a \u2018multi-hit\u2019 hypothesis in the pathogenesis of periodontitis-mediated intestinal inflammation. Furthermore, the review underscores the critical need for a collaborative approach between dentists and gastroenterologists to provide holistic oral\u2013systemic healthcare.<\/jats:p>","DOI":"10.1093\/ecco-jcc\/jjae028","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T22:09:00Z","timestamp":1709158140000},"page":"1319-1341","source":"Crossref","is-referenced-by-count":71,"title":["Unravelling the Oral\u2013Gut Axis: Interconnection Between Periodontitis and Inflammatory Bowel Disease, Current Challenges, and Future Perspective"],"prefix":"10.1093","volume":"18","author":[{"given":"Himanshi","family":"Tanwar","sequence":"first","affiliation":[{"name":"Division of Periodontology, University of Maryland School of Dentistry , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeba Mercy","family":"Gnanasekaran","sequence":"additional","affiliation":[{"name":"Division of Periodontology, University of Maryland School of Dentistry , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devon","family":"Allison","sequence":"additional","affiliation":[{"name":"Division of Periodontology, University of Maryland School of Dentistry , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-shiang","family":"Chuang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The Forsyth Institute , Cambridge, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Aimetti","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, C.I.R. Dental School, University of Turin , Turin , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Baima","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, C.I.R. 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Rev"},{"key":"2024082420322219600_CIT0270","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1600-0757.1999.tb00162.x","article-title":"Virulence factors of Porphyromonas gingivalis","volume":"20","author":"Holt","year":"1999","journal-title":"Periodontology 2000"},{"key":"2024082420322219600_CIT0271","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1600-0765.1997.tb01392.x","article-title":"Porphyromonas gingivalis proteinases as virulence factors in the development of periodontitis","volume":"32","author":"Travis","year":"1997","journal-title":"J Periodontal Res"},{"key":"2024082420322219600_CIT0272","first-page":"25","article-title":"Role of Fusobacterium nucleatum in periodontal health and disease","volume":"13","author":"Signat","year":"2011","journal-title":"Curr Issues Mol Biol"},{"key":"2024082420322219600_CIT0273","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1128\/IAI.06276-11","article-title":"Fusobacterium nucleatum and 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