{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:02:04Z","timestamp":1792443724227,"version":"4.5.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["EXC 2167-390884018"],"award-info":[{"award-number":["EXC 2167-390884018"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>Though colonoscopy plays a crucial role in assessing active ulcerative colitis [aUC], its scope is limited to the mucosal surface. Endoscopic ultrasound [EUS] coupled with contrast-enhancement [dCEUS] can precisely quantify bowel wall thickness and microvascular circulation, potentially enabling the quantitative evaluation of inflammation. We conducted a prospective, longitudinal study to assess therapy response using dCEUS in aUC patients undergoing treatment with adalimumab [ADA] or infliximab [IFX].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Thirty ADA- and 15 IFX-treated aUC patients were examined at baseline and at 2, 6, and 14 weeks of therapy and 48 weeks of follow-up. Bowel wall thickness [BWT] was measured by EUS in the rectum. Vascularity was quantified by dCEUS using rise time [RT] and time to peak [TTP]. Therapy response was defined after 14 weeks using the Mayo Score.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients with aUC displayed a mean BWT of 3.9\u2005\u00b1\u20050.9 mm. In case of response to ADA\/IFX a significant reduction in BWT was observed after 2 weeks [p\u2005=\u20050.04], whereas non-responders displayed no significant changes. The TTP was notably accelerated at baseline and significantly normalized by week 2 in responders [p\u2005=\u20050.001], while non-responders exhibited no significant alterations [p\u2005=\u20050.9]. At week 2, the endoscopic Mayo score did not exhibit any changes, thus failing to predict treatment responses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>dCEUS enables the early detection of therapy response in patients with aUC, which serves as a predictive marker for long-term clinical success. Therefore, dCEUS serves as a diagnostic tool for assessing the probability of future therapy success.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjae034","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T18:28:23Z","timestamp":1709922503000},"page":"1012-1024","source":"Crossref","is-referenced-by-count":11,"title":["Contrast-Enhanced Endoscopic Ultrasound Detects Early Therapy Response Following Anti-TNF Therapy in Patients with Ulcerative Colitis"],"prefix":"10.1093","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5817-5589","authenticated-orcid":false,"given":"Mark","family":"Ellrichmann","sequence":"first","affiliation":[{"name":"Interdisciplinary Endoscopy, Medical Department I, University Hospital Schleswig-Holstein , Campus Kiel, Kiel , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berenice","family":"Schulte","sequence":"additional","affiliation":[{"name":"Interdisciplinary Endoscopy, Medical Department I, University Hospital Schleswig-Holstein , Campus Kiel, Kiel , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio C","family":"Conrad","sequence":"additional","affiliation":[{"name":"Interdisciplinary Endoscopy, Medical Department I, University Hospital Schleswig-Holstein , Campus Kiel, Kiel , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Schoch","sequence":"additional","affiliation":[{"name":"Interdisciplinary Endoscopy, Medical Department I, University Hospital Schleswig-Holstein , Campus Kiel, Kiel , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Bethge","sequence":"additional","affiliation":[{"name":"Interdisciplinary Endoscopy, Medical Department I, University Hospital Schleswig-Holstein , Campus Kiel, Kiel , 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