{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:00:36Z","timestamp":1789729236972,"version":"4.0.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100001295","name":"Pinkerton Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001295","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005155","name":"Azrieli Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>Several faecal microbial transplantation [FMT] approaches for ulcerative colitis [UC] have been investigated with conflicting results. We have recently published the clinical outcomes from the CRAFT UC Trial using FMT with the UC Exclusion Diet [UCED], compared with FMT alone. Here we aimed to compare the two FMT strategies in terms of microbial profile and function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Subjects recruited to the CRAFT UC study with available pre- and post-intervention faecal samples were included. Donors received diet conditioning for 14\u00a0days based on the UCED principles. Group 1 received single FMT by colonoscopy [Day 1] and enemas [Days 2 and 14] without donors\u2019 dietary conditioning [N\u00a0=\u00a011]. Group 2 received FMT but with donors\u2019 dietary pre-conditioning and UCED for the patients [N\u2005=\u200510]. Faecal samples were assessed by DNA shotgun metagenomic sequencing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Following diet conditioning, donors showed depletion in metabolic pathways involved in biosynthesis of sulphur-containing amino acids. Only Group 2 showed significant shifts towards the donors\u2019 microbial composition [ADONIS: R2\u2005=\u20050.15, p\u2005=\u20050.008] and significantly increased Eubacterium_sp_AF228LB post-intervention [\u03b2-coefficient 2.66, 95% confidence interval 2.1\u20133.3, q\u2005&amp;lt;\u20050.05] which was inversely correlated with faecal calprotectin [rho\u2005=\u2005\u22120.52, p\u2005=\u20050.035]. Moreover, pathways involved in gut inflammation and barrier function including branched chain amino acids were enriched post-intervention in Group 2 and were significantly inversely correlated with faecal calprotectin.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>FMT from diet conditioned donors followed by the UCED led to microbial alterations associated with favourable microbial profiles which correlated with decreased faecal calprotectin. Our findings support further exploration of the additive benefit of dietary intervention for both donors and patients undergoing FMT as a potential treatment of UC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjae062","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T07:01:01Z","timestamp":1715238061000},"source":"Crossref","is-referenced-by-count":5,"title":["Faecal Transplantation for Ulcerative Colitis From Diet Conditioned Donors Followed by Dietary Intervention Results in Favourable Gut Microbial Profile Compared to Faecal Transplantation Alone"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4172-6903","authenticated-orcid":false,"given":"Haim","family":"Leibovitzh","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tel Aviv Sourasky Medical Center , Tel Aviv , Israel"},{"name":"Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Sarbagili Shabat","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit, PIBD Research Center, Wolfson Medical Center , Holon , Israel"},{"name":"Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayal","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tel Aviv Sourasky Medical Center , Tel Aviv , Israel"},{"name":"Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3378-4932","authenticated-orcid":false,"given":"Eran","family":"Zittan","sequence":"additional","affiliation":[{"name":"Gastroenterology Institute, IBD Unit, Haemek Medical Center , Afula , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Chiara","family":"Mentella","sequence":"additional","affiliation":[{"name":"UOC di Nutrizione Clinica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Universit\u00e0 Cattolica del Sacro Cuore , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4396-1613","authenticated-orcid":false,"given":"Valentina","family":"Petito","sequence":"additional","affiliation":[{"name":"Cemad [CENTER for Digestive Disease], UOC Medicina Internae Gastroenterologia, Fondazione Policlinico \u2018A. 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