{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:33:12Z","timestamp":1790299992233,"version":"4.1.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Danish Research Council"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>Reliable and easily accessible objective markers of disease activity to predict long-term treatment outcomes in severe ulcerative colitis [UC] are missing. We aimed to investigate if intestinal ultrasound [IUS] might predict long-term outcomes in hospitalised patients with severe UC, treated with intravenous [IV] corticosteroids.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Hospitalised patients with severe UC and IUS inflammation (bowel wall thickness [BWT]\u2005&amp;gt;\u20053.0 mm) starting IV corticosteroids were recruited at three university hospitals in Denmark. IUS was performed before treatment and 48\u2005\u00b1\u200524 h, 6\u2005\u00b1\u20051 days, and 3 months after treatment initiation. Time until colectomy or need for new interventions was registered together with Mayo score at 3 months and partial Mayo score [pMayo] at 12 months. Follow-up time was 12 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In the final analysis, 56 patients were included; 45 [80%] patients needed intervention, including nine colectomies, during the 12-month follow-up. After 48\u2005\u00b1\u200524 h, no patient with a BWT\u2005&amp;lt;\u20053 mm needed a colectomy, p\u2005=\u20050.04. BWT\u2005\u2265\u20054 mm showed an increased risk of colectomy {odds ratio 9.5 (95% confidence interval [CI] 1.5\u2013186), p\u2005=\u20050.03}, whereas a BWT\u2005\u2265\u20053 mm showed an increased risk of intervention (3.6 [1.1\u201312.5], p\u2005=\u20050.03). A BWT\u2005\u2265\u20054 mm resulted in a significantly shorter time until both colectomy, p\u2005=\u20050.03, and treatment intensification (mean days 75 [95% CI 24\u2013127] vs 176 [119\u2013233], p\u2005=\u20050.005). However, neither IUS parameters nor pMayo score, C-reactive protein [CRP], haemoglobin, or p-albumin could predict remission at 3 and 12 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>BWT, assessed at 48 h post intravenous corticosteroid initiation in patients hospitalised with severe UC, may identify patients with an increased risk of short- and long-term colectomy and predict a more aggressive short-term disease course.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjae101","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T06:24:25Z","timestamp":1719469465000},"page":"1976-1986","source":"Crossref","is-referenced-by-count":22,"title":["Early Intestinal Ultrasound in Severe Ulcerative Colitis Identifies Patients at Increased Risk of 1-Year Treatment Failure and Colectomy"],"prefix":"10.1093","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7792-9008","authenticated-orcid":false,"given":"Johan F K F","family":"Ilvemark","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Copenhagen University Hospital \u2013 Gentofte and Herlev , Herlev ,","place":["Denmark"]},{"name":"CIUS \u2013 Copenhagen Intestinal Ultrasound , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4928-4708","authenticated-orcid":false,"given":"Rune","family":"Wilkens","sequence":"additional","affiliation":[{"name":"CIUS \u2013 Copenhagen Intestinal Ultrasound , Copenhagen ,","place":["Denmark"]},{"name":"Digestive Disease Center, Copenhagen University Hospital \u2013 Bispebjerg and Frederiksberg , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Thielsen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Copenhagen University Hospital \u2013 Gentofte and Herlev , Herlev ,","place":["Denmark"]},{"name":"CIUS \u2013 Copenhagen Intestinal Ultrasound , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Dige","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology, Aarhus University Hospital , Aarhus ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5116-5716","authenticated-orcid":false,"given":"Trine","family":"Boysen","sequence":"additional","affiliation":[{"name":"CIUS \u2013 Copenhagen Intestinal Ultrasound , Copenhagen ,","place":["Denmark"]},{"name":"Gastrounit, Medical Division, Copenhagen University Hospital - Amager and Hvidovre , Hvidovre ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rn","family":"Brynskov","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Copenhagen University Hospital \u2013 Gentofte and Herlev , Herlev ,","place":["Denmark"]},{"name":"CIUS \u2013 Copenhagen Intestinal Ultrasound , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob T","family":"Bjerrum","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Copenhagen University Hospital \u2013 Gentofte and Herlev , Herlev ,","place":["Denmark"]},{"name":"CIUS \u2013 Copenhagen Intestinal Ultrasound , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3230-7966","authenticated-orcid":false,"given":"Jakob B","family":"Seidelin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Copenhagen University Hospital \u2013 Gentofte and Herlev , Herlev ,","place":["Denmark"]},{"name":"CIUS \u2013 Copenhagen Intestinal Ultrasound , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"2024121223381687200_CIT0001","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1093\/ecco-jcc\/jjy154","article-title":"Natural disease course of ulcerative colitis during the first five years of follow-up in a European population-based inception cohort: an Epi-IBD Study","volume":"13","author":"Burisch","year":"2019","journal-title":"J Crohns Colitis"},{"key":"2024121223381687200_CIT0002","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1093\/ecco-jcc\/jjab177","article-title":"ECCO guidelines on therapeutics in ulcerative colitis: surgical treatment","volume":"16","author":"Spinelli","year":"2022","journal-title":"J Crohns Colitis"},{"key":"2024121223381687200_CIT0003","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.crohns.2010.02.001","article-title":"The pattern and outcome of acute severe colitis","volume":"4","author":"Dinesen","year":"2010","journal-title":"J Crohns Colitis"},{"key":"2024121223381687200_CIT0004","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1093\/ecco-jcc\/jjaa265","article-title":"Predicting outcome in acute severe colitis: controversies in clinical practice in 2021","volume":"15","author":"Gupta","year":"2021","journal-title":"J Crohns Colitis"},{"key":"2024121223381687200_CIT0005","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.cgh.2018.06.031","article-title":"Effect of accelerated infliximab induction on short- and long-term outcomes of acute severe ulcerative colitis: a retrospective multicenter study and meta-analysis","volume":"17","author":"Nalagatla","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2024121223381687200_CIT0006","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1093\/ecco-jcc\/jjac083","article-title":"Early intestinal ultrasound predicts intravenous corticosteroid response in hospitalised patients with severe ulcerative colitis","volume":"16","author":"Ilvemark","year":"2022","journal-title":"J Crohns Colitis"},{"key":"2024121223381687200_CIT0007","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1093\/ecco-jcc\/jjab173","article-title":"Defining transabdominal intestinal ultrasound treatment response and remission in inflammatory bowel disease: systematic review and expert consensus statement","volume":"16","author":"Ilvemark","year":"2022","journal-title":"J Crohns Colitis"},{"key":"2024121223381687200_CIT0008","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1002\/ibd.20520","article-title":"Use of the noninvasive components of the Mayo score to assess clinical response in ulcerative colitis","volume":"14","author":"Lewis","year":"2008","journal-title":"Inflamm Bowel Dis"},{"key":"2024121223381687200_CIT0009","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1136\/bmj.2.4947.1041","article-title":"Cortisone in ulcerative colitis; final report on a therapeutic trial","volume":"2","author":"Truelove","year":"1955","journal-title":"Br Med J"},{"key":"2024121223381687200_CIT0010","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1093\/ecco-jcc\/jjx008","article-title":"Third European evidence-based consensus on diagnosis and management of ulcerative colitis. 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