{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:15:33Z","timestamp":1790673333785,"version":"4.1.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Health","award":["DK125296, DK124274, and DK136829 to TCL, DK062413"],"award-info":[{"award-number":["DK125296, DK124274, and DK136829 to TCL, DK062413"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>Biomarkers that integrate genetic and environmental factors and predict outcome in complex immune diseases such as inflammatory bowel disease (IBD; including Crohn\u2019s disease [CD] and ulcerative colitis [UC]) are needed. We showed that morphological patterns of ileal Paneth cells (Paneth cell phenotype [PCP]; a surrogate for PC function) is one such cellular biomarker for CD. Given the shared features between CD and UC, we hypothesised that PCP is also associated with molecular\/genetic features and outcome in UC. Because PC density is highest in the ileum, we further hypothesised that PCP predicts outcome in UC subjects undergoing total colectomy and ileal pouch-anal anastomosis [IPAA].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Uninflamed ileal resection margins from UC subjects with colectomy and IPAA were used for PCP and transcriptomic analyses. PCP was defined using defensin 5 immunofluorescence. Genotyping was performed using Immunochip. UC transcriptomic and genotype associations of PCP were incorporated with data from CD subjects to identify common IBD-related pathways and genes that regulate PCP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The prevalence of abnormal ileal PCP was 27%, comparable to that seen in CD. Combined analysis of UC and CD subjects showed that abnormal PCP was associated with transcriptomic pathways of secretory granule maturation and polymorphisms in innate immunity genes. Abnormal ileal PCP at the time of colectomy was also associated with pouch complications including de novo CD in the pouch and time to first episode of pouchitis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Ileal PCP is biologically and clinically relevant in UC and can be used as a biomarker in IBD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjae105","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T16:53:45Z","timestamp":1719852825000},"page":"2010-2022","source":"Crossref","is-referenced-by-count":7,"title":["Ileal Paneth Cell Phenotype is a Cellular Biomarker for Pouch Complications in Ulcerative Colitis"],"prefix":"10.1093","volume":"18","author":[{"given":"Changqing","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9005-7750","authenticated-orcid":false,"given":"Talin","family":"Haritunians","sequence":"additional","affiliation":[{"name":"F. Widjaja Foundation Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center , Los Angeles, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas K","family":"Gremida","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine , St. Louis, MO ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Syal","sequence":"additional","affiliation":[{"name":"F. Widjaja Foundation Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center , Los Angeles, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janaki","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine , St. Louis, MO ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohong","family":"Yang","sequence":"additional","affiliation":[{"name":"F. Widjaja Foundation Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center , Los Angeles, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Ramos Del Aguila de Rivers","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine , St. Louis, MO ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad E","family":"Storer","sequence":"additional","affiliation":[{"name":"Department of Genetics, Washington University School of Medicine , St. Louis, MO ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Washington University School of Medicine , St. Louis, MO ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emebet","family":"Mengesha","sequence":"additional","affiliation":[{"name":"F. Widjaja Foundation Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center , Los Angeles, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Mujukian","sequence":"additional","affiliation":[{"name":"F. Widjaja Foundation Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center , Los Angeles, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Hanna","sequence":"additional","affiliation":[{"name":"F. Widjaja Foundation Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center , Los Angeles, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Fleshner","sequence":"additional","affiliation":[{"name":"F. Widjaja Foundation Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center , Los Angeles, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G","family":"Binion","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine , St. Louis, MO ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5810-0720","authenticated-orcid":false,"given":"Kelli L","family":"VanDussen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaddeus S","family":"Stappenbeck","sequence":"additional","affiliation":[{"name":"Department of Inflammation and Immunity, Cleveland Clinic Lerner Research Institute , Cleveland, OH ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D","family":"Head","sequence":"additional","affiliation":[{"name":"Department of Genetics, Washington University School of Medicine , St. Louis, MO ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A","family":"Ciorba","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine , St. Louis, MO ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dermot P B","family":"McGovern","sequence":"additional","affiliation":[{"name":"F. Widjaja Foundation Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center , Los Angeles, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ta-Chiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,2]]},"reference":[{"key":"2024121223382315100_CIT0001","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet"},{"key":"2024121223382315100_CIT0002","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/ajg.2014.110","article-title":"Toward a personalized medicine approach to the management of inflammatory bowel 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