{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:36:51Z","timestamp":1772138211909,"version":"3.50.1"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","award":["0059377"],"award-info":[{"award-number":["0059377"]}],"id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The natural history of Crohn\u2019s disease leading to intestinal failure is not well characterised. This study aims to describe the clinical course of Crohn\u2019s disease preceding intestinal failure and to compare disease course and burden between Crohn\u2019s disease patients with and without intestinal failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with Crohn\u2019s disease complicated by intestinal failure from Rigshospitalet, Copenhagen [n\u2005=\u2005182] and a nationwide Danish Crohn\u2019s disease cohort without intestinal failure [n\u2005=\u200522,845] were included. Using nationwide registries in Denmark, disease course was determined from hospitalisations, surgeries, and outpatient medications, and disease burden was determined from employment and mortality data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The 10-year cumulative incidence of intestinal failure following Crohn\u2019s disease diagnosis declined from 2.7% prior to 1980 to 0.2% after 2000. Compared with Crohn\u2019s disease patients without intestinal failure, those with intestinal failure experienced significantly longer duration of severe disease [50 vs 19 years per 100 patient-years, p\u2005&amp;lt;\u20050.01], secondary to greater corticosteroid use [71% vs 60%, p\u2005=\u20050.02], inpatient contacts [98% vs 55%, p\u2005&amp;lt;\u20050.01], and abdominal surgeries [99% vs 48%, p\u2005&amp;lt;\u20050.01]. However, exposure to biologics was not different between the two groups [20.4% vs 21%, p\u2005=\u20050.95], and duration on biologics was shorter in Crohn\u2019s disease patients with intestinal failure [2068 vs 4126 days per 100 patient-years, p\u2005=\u20050.02]. Standard mortality ratio in Crohn\u2019s disease patients with intestinal failure was 3.66 (97.5% confidence interval [CI] 2.79, 4.72].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with Crohn\u2019s disease complicated by intestinal failure experienced a more persistently severe preceding course of Crohn\u2019s disease but were not more likely to be treated with biological therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjae114","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T02:43:23Z","timestamp":1721702603000},"source":"Crossref","is-referenced-by-count":3,"title":["The Natural History of Crohn\u2019s Disease Leading to Intestinal Failure: A Longitudinal Cohort Study from 1973 to 2018"],"prefix":"10.1093","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4667-6263","authenticated-orcid":false,"given":"Tian Hong","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Intestinal Failure and Liver Diseases , Rigshospitalet, Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher Filtenborg","family":"Brandt","sequence":"additional","affiliation":[{"name":"Department of Intestinal Failure and Liver Diseases , Rigshospitalet, Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2148-4740","authenticated-orcid":false,"given":"Thomas","family":"Scheike","sequence":"additional","affiliation":[{"name":"Department of Public Health, Section of Biostatistics, University of Copenhagen , Copenhagen 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