{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T10:50:29Z","timestamp":1793875829378,"version":"4.7.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Deutsche Forschungs-gemeinschaft","award":["375876048\u2014TRR241 (B04)"],"award-info":[{"award-number":["375876048\u2014TRR241 (B04)"]}]},{"name":"ZIM\/BMWi grant","award":["ZF4010106MD9"],"award-info":[{"award-number":["ZF4010106MD9"]}]},{"name":"the iIMMUNE_ACS","award":["01EO2105"],"award-info":[{"award-number":["01EO2105"]}]},{"name":"the iIMMUNE_ACS","award":["BMBF"],"award-info":[{"award-number":["BMBF"]}]},{"name":"Interdisciplinary Center for Clinical Research (IZKF) of the University Erlangen-N\u00fcrnberg","award":["J63"],"award-info":[{"award-number":["J63"]}]},{"name":"Interdisciplinary Center for Clinical Research (IZKF) of the University Erlangen-N\u00fcrnberg","award":["J68"],"award-info":[{"award-number":["J68"]}]},{"name":"IZKF of the University Erlangen-N\u00fcrnberg"},{"name":"YAEL Foundation and Hannelore and Helmut Greve Foundation"},{"name":"Deutsche Forschungs-gemeinschaft","award":["Nr. 290522633"],"award-info":[{"award-number":["Nr. 290522633"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recently, autoantibodies directed against the epithelial adhesion protein integrin \u03b1V\u03b26 have been identified that are strongly associated with ulcerative colitis (UC). We aimed to elucidate whether anti-integrin \u03b1V\u03b26 (anti-\u03b1V\u03b26) is present in primary sclerosing cholangitis (PSC), its associated inflammatory bowel disease, or other cholestatic liver diseases and their persistence after proctocolectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We detected anti-\u03b1V\u03b26 by an enzyme-linked immunosorbent assay in sera collected at 2 German tertiary centers, including healthy controls (N\u2005=\u200562), UC (N\u2005=\u200536), Crohn\u2019s disease (CD, N\u2005=\u200565), PSC-inflammatory bowel diseases (IBD) (78 samples from N\u2005=\u200541 patients), PSC without IBD (PSC, 41 samples from N\u2005=\u200518 patients), primary biliary cholangitis (PBC, N\u2005=\u200524), autoimmune hepatitis (AIH, N\u2005=\u200532), secondary sclerosing cholangitis (SSC, N\u2005=\u200512), and metabolic dysfunction-associated steatotic liver disease (MASLD, N\u2005=\u200524). In addition, sera after proctocolectomy were studied (44 samples\/N\u2005=\u200510 patients). Immunofluorescent analyses were performed in tissue samples from liver, large bile duct from surgical resections, and colon of PSC patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Anti-\u03b1V\u03b26 occurred in 91% of UC, 17% of CD, 73% of PSC-IBD, 39% of PSC, 4% of PBC, 14% of AIH, and 0% of healthy controls, SSC, or MASLD. Integrin \u03b1V\u03b26 is selectively expressed in disease-associated epithelia of both bile duct and colon. Anti-\u03b1V\u03b26 levels correlate moderately with intestinal disease activity in PSC-IBD, but only weakly with biliary disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Anti-\u03b1V\u03b26 frequently occurs in patients suffering from PSC, especially in PSC-IBD. Anti-\u03b1V\u03b26 levels positively correlate to IBD activity in PSC-IBD, but may also occur in the absence of clinically manifest IBD in PSC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjae131","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T20:26:02Z","timestamp":1724963162000},"source":"Crossref","is-referenced-by-count":13,"title":["Integrin \u03b1V\u03b26: Autoantigen and Driver of Epithelial Remodeling in Colon and Bile Ducts in Primary Sclerosing Cholangitis and Inflammatory Bowel Disease"],"prefix":"10.1093","volume":"19","author":[{"given":"Dominik","family":"Roth","sequence":"first","affiliation":[{"name":"Department of Medicine 1, Gastroenterology, Pneumology and Endocrinology, Friedrich Alexander University Erlangen-N\u00fcrnberg, Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam M","family":"D\u00fcll","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, Gastroenterology, Pneumology and Endocrinology, Friedrich Alexander University Erlangen-N\u00fcrnberg, Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]},{"name":"Deutsches Zentrum f\u00fcr Immuntherapie (DZI), Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg and Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwig J","family":"Horst","sequence":"additional","affiliation":[{"name":"Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aylin","family":"Lindemann","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, Gastroenterology, Pneumology and Endocrinology, Friedrich Alexander University Erlangen-N\u00fcrnberg, Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xenia","family":"Malzer","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, Gastroenterology, Pneumology and Endocrinology, Friedrich Alexander University Erlangen-N\u00fcrnberg, Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1672-7234","authenticated-orcid":false,"given":"Kristina","family":"Koop","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, Gastroenterology, Pneumology and Endocrinology, Friedrich Alexander University Erlangen-N\u00fcrnberg, Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0888-2784","authenticated-orcid":false,"given":"Sebastian","family":"Zundler","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, Gastroenterology, Pneumology and Endocrinology, Friedrich Alexander University Erlangen-N\u00fcrnberg, Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]},{"name":"Deutsches Zentrum f\u00fcr Immuntherapie (DZI), Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg and Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Vetter","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, Gastroenterology, Pneumology and Endocrinology, Friedrich Alexander University Erlangen-N\u00fcrnberg, Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]},{"name":"Deutsches Zentrum f\u00fcr Immuntherapie (DZI), Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg and Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Jefremow","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, Gastroenterology, Pneumology and Endocrinology, Friedrich Alexander University Erlangen-N\u00fcrnberg, Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]},{"name":"Deutsches Zentrum f\u00fcr Immuntherapie (DZI), Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg and Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8556-8433","authenticated-orcid":false,"given":"Raja","family":"Atreya","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, Gastroenterology, Pneumology and Endocrinology, Friedrich Alexander University Erlangen-N\u00fcrnberg, Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]},{"name":"Deutsches Zentrum f\u00fcr Immuntherapie (DZI), Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg and Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Geppert","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander Universit\u00e4t Erlangen-N\u00fcrnberg , Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f6ren","family":"Weidemann","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University Medical Centre Hamburg-Eppendorf (UKE) , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian J","family":"Waldner","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, Gastroenterology, Pneumology and Endocrinology, Friedrich Alexander University Erlangen-N\u00fcrnberg, Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]},{"name":"Deutsches Zentrum f\u00fcr Immuntherapie (DZI), Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg and Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, Gastroenterology, Pneumology and Endocrinology, Friedrich Alexander University Erlangen-N\u00fcrnberg, Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]},{"name":"Deutsches Zentrum f\u00fcr Immuntherapie (DZI), Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg and Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]},{"name":"Institute of Biochemistry, Emil-Fischer-Zentrum, Friedrich-Alexander-University Erlangen-N\u00fcrnberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"G\u00fcnther","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, Gastroenterology, Pneumology and Endocrinology, Friedrich Alexander University Erlangen-N\u00fcrnberg, Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis E","family":"Munoz","sequence":"additional","affiliation":[{"name":"Deutsches Zentrum f\u00fcr Immuntherapie (DZI), Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg and Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]},{"name":"Department of Medicine 3,\u00a0Rheumatology and Immunology, Friedrich-Alexander University Erlangen-N\u00fcrnberg, Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Deutsches Zentrum f\u00fcr Immuntherapie (DZI), Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg and Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]},{"name":"Department of Medicine 3,\u00a0Rheumatology and Immunology, Friedrich-Alexander University Erlangen-N\u00fcrnberg, Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Scheffold","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Christian-Albrechts-Universit\u00e4t zu Kiel & Universit\u00e4tsklinik Schleswig-Holstein , Kiel ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus F","family":"Neurath","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, Gastroenterology, Pneumology and Endocrinology, Friedrich Alexander University Erlangen-N\u00fcrnberg, Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]},{"name":"Deutsches Zentrum f\u00fcr Immuntherapie (DZI), Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg and Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Siebler","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, Gastroenterology, Pneumology and Endocrinology, Friedrich Alexander University Erlangen-N\u00fcrnberg, Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]},{"name":"Deutsches Zentrum f\u00fcr Immuntherapie (DZI), Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg and Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Schramm","sequence":"additional","affiliation":[{"name":"Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas E","family":"Kremer","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, Gastroenterology, Pneumology and Endocrinology, Friedrich Alexander University Erlangen-N\u00fcrnberg, Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]},{"name":"Deutsches Zentrum f\u00fcr Immuntherapie (DZI), Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg and Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]},{"name":"Department of Hepatology and Gastroenterology, University Hospital Z\u00fcrich and University Z\u00fcrich , Z\u00fcrich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Leppkes","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, Gastroenterology, Pneumology and Endocrinology, Friedrich Alexander University Erlangen-N\u00fcrnberg, Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]},{"name":"Deutsches Zentrum f\u00fcr Immuntherapie (DZI), Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg and Universit\u00e4tsklinikum Erlangen , Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"key":"2025021912245141100_CIT0001","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/S0140-6736(07)60751-X","article-title":"Inflammatory bowel disease: clinical aspects and established and evolving therapies","volume":"369","author":"Baumgart","year":"2007","journal-title":"Lancet"},{"key":"2025021912245141100_CIT0002","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/hep.1840010612","article-title":"Morphologic features of chronic hepatitis associated with primary sclerosing cholangitis and chronic ulcerative colitis","volume":"1","author":"Ludwig","year":"1981","journal-title":"Hepatology"},{"key":"2025021912245141100_CIT0003","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1056\/NEJMra1506330","article-title":"Primary sclerosing cholangitis","volume":"375","author":"Lazaridis","year":"2016","journal-title":"N Engl J Med"},{"key":"2025021912245141100_CIT0004","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1136\/gut.2004.046615","article-title":"PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis","volume":"54","author":"LoftusHarewood","year":"2005","journal-title":"Gut"},{"key":"2025021912245141100_CIT0005","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41580-019-0134-2","article-title":"Integrins as biomechanical sensors of the microenvironment","volume":"20","author":"Kechagia","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2025021912245141100_CIT0006","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.addr.2018.01.020","article-title":"Integrins in wound healing, fibrosis and tumor stroma: high potential targets for therapeutics and drug delivery","volume":"129","author":"Schnittert","year":"2018","journal-title":"Adv Drug Deliv Rev"},{"key":"2025021912245141100_CIT0007","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1513\/AnnalsATS.201406-245MG","article-title":"Epithelial-mesenchymal interactions in fibrosis and repair: transforming growth factor-beta activation by epithelial cells and fibroblasts","volume":"12","author":"Sheppard","year":"2015","journal-title":"Ann Am Thorac Soc"},{"key":"2025021912245141100_CIT0008","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/s41568-018-0038-z","article-title":"Every step of the way: integrins in cancer progression and metastasis","volume":"18","author":"Hamidi","year":"2018","journal-title":"Nat Rev Cancer"},{"key":"2025021912245141100_CIT0009","doi-asserted-by":"crossref","first-page":"891","DOI":"10.3389\/fimmu.2017.00891","article-title":"Anti-adhesion therapies in inflammatory bowel disease-molecular and clinical aspects","volume":"8","author":"Zundler","year":"2017","journal-title":"Front Immunol"},{"key":"2025021912245141100_CIT0010","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1242\/jcs.108.6.2241","article-title":"Expression of the Beta 6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling","volume":"108","author":"Breuss","year":"1995","journal-title":"J Cell Sci"},{"key":"2025021912245141100_CIT0011","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1053\/j.gastro.2021.02.019","article-title":"Identification of an anti-integrin alphavbeta6 autoantibody in patients with ulcerative colitis","volume":"160","author":"Kuwada","year":"2021","journal-title":"Gastroenterology"},{"key":"2025021912245141100_CIT0012","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1053\/j.gastro.2022.06.026","article-title":"Anti-integrin alphavbeta6 antibody as a diagnostic marker for pediatric patients with ulcerative colitis","volume":"163","author":"Muramoto","year":"2022","journal-title":"Gastroenterology"},{"key":"2025021912245141100_CIT0013","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.3390\/jcm11071881","article-title":"Measurement of serum IgG anti-integrin alphavbeta6 autoantibodies is a promising tool in the diagnosis of ulcerative colitis","author":"Rydell","year":"2022","journal-title":"J Clin Med"},{"key":"2025021912245141100_CIT0014","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1136\/gutjnl-2021-324725","article-title":"Neutrophils prevent rectal bleeding in ulcerative colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis","volume":"71","author":"Leppkes","year":"2022","journal-title":"Gut"},{"key":"2025021912245141100_CIT0015","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1007\/s00535-023-02006-6","article-title":"Anti-integrin alphavbeta6 autoantibodies in patients with primary sclerosing cholangitis","volume":"58","author":"Yoshida","year":"2023","journal-title":"J Gastroenterol"},{"key":"2025021912245141100_CIT0016","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.jhep.2023.12.023","article-title":"Single-cell and spatial transcriptomics characterisation of the immunological landscape in the healthy and PSC human liver","volume":"80","author":"Andrews","year":"2024","journal-title":"J Hepatol"},{"key":"2025021912245141100_CIT0017","first-page":"74","article-title":"Colitis-ulcerosa-assoziierte anti-Integrin-\u03b1V","volume":"61","author":"Dominik Roth","year":"2023","journal-title":"Z Gastroenterol."},{"key":"2025021912245141100_CIT0018","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/s41467-018-03751-6","article-title":"Massive mining of publicly available RNA-seq data from human and mouse","volume":"9","author":"Lachmann","year":"2018","journal-title":"Nat Commun"},{"key":"2025021912245141100_CIT0019","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.jhep.2022.05.011","article-title":"EASL Clinical Practice Guidelines on sclerosing cholangitis","volume":"77","author":"European Association for the Study of the Liver","year":"2022","journal-title":"J Hepatol"},{"key":"2025021912245141100_CIT0020","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jhep.2017.03.022","article-title":"EASL Clinical Practice Guidelines: the diagnosis and management of patients with primary biliary cholangitis","volume":"67","author":"European Association for the Study of the Liver\/","year":"2017","journal-title":"J Hepatol"},{"key":"2025021912245141100_CIT0021","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.jhep.2017.07.022","article-title":"Primary sclerosing cholangitis\u2014a comprehensive review","volume":"67","author":"Karlsen","year":"2017","journal-title":"J Hepatol"},{"key":"2025021912245141100_CIT0022","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.3748\/wjg.14.3781","article-title":"Autoantibodies in primary sclerosing cholangitis","volume":"14","author":"Hov","year":"2008","journal-title":"World J Gastroenterol"},{"key":"2025021912245141100_CIT0023","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/apt.16153","article-title":"Anti-glycoprotein 2 (anti-GP2) IgA and anti-neutrophil cytoplasmic antibodies to serine proteinase 3 (PR3-ANCA): antibodies to predict severe disease, poor survival and cholangiocarcinoma in primary sclerosing cholangitis","volume":"53","author":"Wunsch","year":"2021","journal-title":"Aliment Pharmacol Ther"},{"key":"2025021912245141100_CIT0024","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0016-5085(90)90839-S","article-title":"A shared and unique epitope(s) on human colon, skin, and biliary epithelium detected by a monoclonal antibody","volume":"98","author":"Das","year":"1990","journal-title":"Gastroenterology"},{"key":"2025021912245141100_CIT0025","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1136\/gut.51.1.120","article-title":"High frequency of autoantibodies in patients with primary sclerosing cholangitis that bind biliary epithelial cells and induce expression of CD44 and production of interleukin 6","volume":"51","author":"Xu","year":"2002","journal-title":"Gut"},{"key":"2025021912245141100_CIT0026","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1136\/gut.32.2.163","article-title":"Serum and tissue autoantibodies to colonic epithelium in ulcerative colitis","volume":"32","author":"Snook","year":"1991","journal-title":"Gut"},{"key":"2025021912245141100_CIT0027","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1002\/hep.1840200446","article-title":"An autoantigen in PSC? Whither or whether","volume":"20","author":"Van De Water","year":"1994","journal-title":"Hepatology"},{"key":"2025021912245141100_CIT0028","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1091\/mbc.e04-04-0353","article-title":"A critical role of tropomyosins in TGF-beta regulation of the actin cytoskeleton and cell motility in epithelial cells","volume":"15","author":"Bakin","year":"2004","journal-title":"Mol Biol Cell"},{"key":"2025021912245141100_CIT0029","doi-asserted-by":"crossref","first-page":"e0158047","DOI":"10.1371\/journal.pone.0158047","article-title":"Amplification of TGFbeta induced ITGB6 gene transcription may promote pulmonary fibrosis","volume":"11","author":"Tatler","year":"2016","journal-title":"PLoS One"},{"key":"2025021912245141100_CIT0030","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1053\/j.gastro.2007.01.039","article-title":"Biliary epithelial cell antibodies link adaptive and innate immune responses in primary sclerosing cholangitis","volume":"132","author":"Karrar","year":"2007","journal-title":"Gastroenterology"},{"key":"2025021912245141100_CIT0031","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/s41591-022-01680-y","article-title":"Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity","volume":"28","author":"Uzzan","year":"2022","journal-title":"Nat Med"},{"key":"2025021912245141100_CIT0032","doi-asserted-by":"crossref","first-page":"S","DOI":"10.1053\/j.gastro.2022.12.042","article-title":"Anti-integrin alphavbeta6 autoantibodies are a novel biomarker that antedate ulcerative colitis","volume":"164","author":"Livanos","year":"2023","journal-title":"Gastroenterology"},{"key":"2025021912245141100_CIT0033","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1001\/jama.2013.6285","article-title":"Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children","volume":"309","author":"Ziegler","year":"2013","journal-title":"JAMA"},{"key":"2025021912245141100_CIT0034","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1056\/NEJMoa021933","article-title":"Development of autoantibodies before the clinical onset of systemic lupus erythematosus","volume":"349","author":"Arbuckle","year":"2003","journal-title":"N Engl J Med"},{"key":"2025021912245141100_CIT0035","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.dld.2023.06.024","article-title":"Diagnostic value of anti-integrin alphavbeta6 antibodies in ulcerative colitis","volume":"56","author":"Marafini","year":"2024","journal-title":"Dig Liver Dis"},{"key":"2025021912245141100_CIT0036","doi-asserted-by":"crossref","first-page":"725390","DOI":"10.3389\/fmed.2021.725390","article-title":"Molecular and cellular mediators of the gut-liver axis in the progression of liver diseases","volume":"8","author":"Bruneau","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"2025021912245141100_CIT0037","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1084\/jem.20040168","article-title":"Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB\/W mice","volume":"199","author":"Hoyer","year":"2004","journal-title":"J Exp Med"},{"key":"2025021912245141100_CIT0038","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1084\/jem.20161590","article-title":"Antibody-secreting plasma cells persist for decades in human intestine","volume":"214","author":"Landsverk","year":"2017","journal-title":"J Exp Med"},{"key":"2025021912245141100_CIT0039","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1002\/eji.1830241046","article-title":"Regulation of IgG antibody titers by the amount persisting of immune-complexed antigen","volume":"24","author":"Bachmann","year":"1994","journal-title":"Eur J Immunol"},{"key":"2025021912245141100_CIT0040","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1093\/intimm\/10.11.1703","article-title":"Survival of long-lived plasma cells is independent of antigen","volume":"10","author":"Manz","year":"1998","journal-title":"Int Immunol"},{"key":"2025021912245141100_CIT0041","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1136\/jcp.48.8.749","article-title":"Histological discrimination of idiopathic inflammatory bowel disease from other types of colitis","volume":"48","author":"Le Berre","year":"1995","journal-title":"J Clin Pathol"},{"key":"2025021912245141100_CIT0042","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.crohns.2013.06.001","article-title":"European consensus on the histopathology of inflammatory bowel disease","volume":"7","author":"Magro","year":"2013","journal-title":"J Crohns Colitis"},{"key":"2025021912245141100_CIT0043","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1002\/ibd.22864","article-title":"Pediatric ulcerative colitis associated with autoimmune diseases: a distinct form of inflammatory bowel disease","volume":"18","author":"Ordonez","year":"2012","journal-title":"Inflamm Bowel Dis"},{"key":"2025021912245141100_CIT0044","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1136\/gut.32.12.1514","article-title":"Histopathological evaluation of colonic mucosal biopsy specimens in chronic inflammatory bowel disease: diagnostic implications","volume":"32","author":"Seldenrijk","year":"1991","journal-title":"Gut"},{"key":"2025021912245141100_CIT0045","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/S0140-6736(02)11861-7","article-title":"Risk factors for recurrence of primary sclerosing cholangitis of liver allograft","volume":"360","author":"Vera","year":"2002","journal-title":"Lancet"},{"key":"2025021912245141100_CIT0046","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.3748\/wjg.v24.i28.3171","article-title":"Role of colectomy in preventing recurrent primary sclerosing cholangitis in liver transplant recipients","volume":"24","author":"Buchholz","year":"2018","journal-title":"World J Gastroenterol"},{"key":"2025021912245141100_CIT0047","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/00365521.2017.1421705","article-title":"Risk factors and prognosis for recurrent primary sclerosing cholangitis after liver transplantation: a Nordic Multicentre Study","volume":"53","author":"Lindstrom","year":"2018","journal-title":"Scand J Gastroenterol"},{"key":"2025021912245141100_CIT0048","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1093\/ibd\/izz325","article-title":"Activity of inflammatory bowel disease after liver transplantation for primary sclerosing cholangitis predicts poorer clinical outcomes","volume":"26","author":"Peverelle","year":"2020","journal-title":"Inflamm Bowel Dis"},{"key":"2025021912245141100_CIT0049","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0092-8674(00)80545-0","article-title":"The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis","volume":"96","author":"Munger","year":"1999","journal-title":"Cell"},{"key":"2025021912245141100_CIT0050","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1002\/hep.21849","article-title":"Role of alphavbeta6 integrin in acute biliary fibrosis","volume":"46","author":"Wang","year":"2007","journal-title":"Hepatology"},{"key":"2025021912245141100_CIT0051","doi-asserted-by":"crossref","first-page":"e132305","DOI":"10.1172\/JCI132305","article-title":"Bile acid-activated macrophages promote biliary epithelial cell proliferation through integrin alphavbeta6 upregulation following liver injury","volume":"131","author":"Guillot","year":"2021","journal-title":"J Clin Invest"},{"key":"2025021912245141100_CIT0052","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3390\/genes14020517","article-title":"An introduction and overview of RON Receptor Tyrosine Kinase Signaling","volume":"14","author":"Hunt","year":"2023","journal-title":"Genes (Basel)"},{"key":"2025021912245141100_CIT0053","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1158\/0008-5472.CAN-03-2106","article-title":"A novel protein tyrosine kinase NOK that shares homology with platelet-derived growth factor\/fibroblast growth factor receptors induces tumorigenesis and metastasis in nude mice","volume":"64","author":"Liu","year":"2004","journal-title":"Cancer Res"},{"key":"2025021912245141100_CIT0054","doi-asserted-by":"crossref","first-page":"e153519","DOI":"10.1172\/JCI153519","article-title":"The epithelial-specific ER stress sensor ERN2\/IRE1beta enables host-microbiota crosstalk to affect colon goblet cell development","volume":"132","author":"Grey","year":"2022","journal-title":"J Clin Invest"},{"key":"2025021912245141100_CIT0055","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/hep.28274","article-title":"Integrin alphavbeta6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis","volume":"63","author":"Peng","year":"2016","journal-title":"Hepatology"},{"key":"2025021912245141100_CIT0056","article-title":"P.i.i.J","author":"Trauner","year":"2024","journal-title":"J Hepatol"},{"key":"2025021912245141100_CIT0057","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1164\/rccm.202403-0636OC","article-title":"Bexotegrast in patients with idiopathic pulmonary fibrosis: the INTEGRIS-IPF study","volume":"210","author":"Lancaster","year":"2024","journal-title":"Am J Respir Crit Care Med"},{"key":"2025021912245141100_CIT0058","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1164\/rccm.202205-0868LE","article-title":"Randomized phase IIa clinical study of an Anti-alpha(v)beta(6) monoclonal antibody in idiopathic pulmonary fibrosis","volume":"206","author":"Raghu","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"key":"2025021912245141100_CIT0059","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1053\/j.gastro.2008.04.009","article-title":"Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression","volume":"135","author":"Patsenker","year":"2008","journal-title":"Gastroenterology"},{"key":"2025021912245141100_CIT0060","author":"En"}],"container-title":["Journal of Crohn's and Colitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/advance-article-pdf\/doi\/10.1093\/ecco-jcc\/jjae131\/59228878\/jjae131.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/19\/2\/jjae131\/59228878\/jjae131.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/19\/2\/jjae131\/59228878\/jjae131.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T07:25:25Z","timestamp":1739949925000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article\/doi\/10.1093\/ecco-jcc\/jjae131\/7745654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,30]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2,4]]}},"URL":"https:\/\/doi.org\/10.1093\/ecco-jcc\/jjae131","relation":{},"ISSN":["1873-9946","1876-4479"],"issn-type":[{"value":"1873-9946","type":"print"},{"value":"1876-4479","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,2]]},"published":{"date-parts":[[2024,8,30]]},"article-number":"jjae131"}}