{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T14:47:29Z","timestamp":1774277249353,"version":"3.50.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"MAFF-commissioned","award":["JPJ009842"],"award-info":[{"award-number":["JPJ009842"]}]},{"name":"Grants-in-Aid for Scientific Research (KAKENHI)","award":["18K06224"],"award-info":[{"award-number":["18K06224"]}]},{"name":"Grants-in-Aid for Scientific Research (KAKENHI)","award":["20K08292"],"award-info":[{"award-number":["20K08292"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Ulcerative colitis (UC) is a chronic inflammatory disease of unknown cause, for which no curative treatments have been developed. Cytokines play an important role in the pathogenesis of UC, and therapies targeting specific cytokines have been successful in treating refractory UC. The purpose of this study was to measure mucosal cytokines in UC and identify those that contribute to nonrelapsing mucosal healing (MH) diagnosed by endoscopy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This prospective, observational study included 163 patients with UC. The mucosa was evaluated by the Mayo Endoscopic Subscore (MES) and linked color imaging (LCI) at the time of endoscopy, and cytokine mRNA expression in biopsy tissue taken from the same site was quantified by real-time PCR and compared with endoscopic findings. The relationship between cytokine mRNA expression and endoscopic findings was investigated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Cytokines such as IFN\u03b3, IL-1\u03b2, IL-8, IL-17A, and IL-23 were significantly elevated in proportion to endoscopic severity of MES and LCI classification. Interestingly, we found differences in the expression of cytokines (eg, IL-22 and IL-33) between MES and LCI classification according to disease severity. Additionally, pathway analysis based on RNA sequencing comparing LCI-A and LCI-B in patients diagnosed as MES 0 revealed that IL-5 and IL-6 are involved in the finer differences in endoscopic mucosal redness.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study is the first to report the correlation between mucosal cytokine expression and the pathogenesis of MH in UC and supports the contribution of specific cytokines as molecular markers of MH or in the pathogenesis of MH in UC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjae158","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T12:43:17Z","timestamp":1729082597000},"source":"Crossref","is-referenced-by-count":3,"title":["Mucosal Cytokine Expression Associated With Deep Endoscopic Mucosal Healing in Ulcerative Colitis"],"prefix":"10.1093","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5210-167X","authenticated-orcid":false,"given":"Kazuhiko","family":"Uchiyama","sequence":"first","affiliation":[{"name":"Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohisa","family":"Takagi","sequence":"additional","affiliation":[{"name":"Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, , Kyoto ,","place":["Japan"]},{"name":"Graduate School of Medical Science, Kyoto Prefectural University of Medicine Department for Medical Innovation and Translational Medical Science, , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsura","family":"Mizushima","sequence":"additional","affiliation":[{"name":"Kyoto Prefectural University of Medicine Department of Human Immunology and Nutrition Science, , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuko","family":"Hirai","sequence":"additional","affiliation":[{"name":"Kyoto Prefectural University of Medicine Department of Human Immunology and Nutrition Science, , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiki","family":"Murakami","sequence":"additional","affiliation":[{"name":"Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Asaeda","sequence":"additional","affiliation":[{"name":"Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Kajiwara-Kubota","sequence":"additional","affiliation":[{"name":"Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saori","family":"Kashiwagi","sequence":"additional","affiliation":[{"name":"Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Minagawa","sequence":"additional","affiliation":[{"name":"Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuma","family":"Hotta","sequence":"additional","affiliation":[{"name":"Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Inoue","sequence":"additional","affiliation":[{"name":"Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Katada","sequence":"additional","affiliation":[{"name":"Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Kamada","sequence":"additional","affiliation":[{"name":"Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Konishi","sequence":"additional","affiliation":[{"name":"Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuo","family":"Kishimoto","sequence":"additional","affiliation":[{"name":"Kyoto City Hospital Department of Surgical Pathology, , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5443-788X","authenticated-orcid":false,"given":"Yuji","family":"Naito","sequence":"additional","affiliation":[{"name":"Kyoto Prefectural University of Medicine Department of Human Immunology and Nutrition Science, , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshito","family":"Itoh","sequence":"additional","affiliation":[{"name":"Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,10,16]]},"reference":[{"key":"2025032700481218600_CIT0001","doi-asserted-by":"crossref","first-page":"103017","DOI":"10.1016\/j.autrev.2021.103017","article-title":"The influence of cytokines on the complex pathology of ulcerative colitis","volume":"21","author":"Nakase","year":"2022","journal-title":"Autoimmun Rev"},{"key":"2025032700481218600_CIT0002","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/ecco-jcc\/jjz154","article-title":"IL-13 mRNA tissue content identifies two subsets of adult ulcerative colitis patients with different clinical and mucosa-associated microbiota profiles","volume":"14","author":"Butera","year":"2020","journal-title":"J Crohns Colitis"},{"key":"2025032700481218600_CIT0003","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1093\/ibd\/izy395","article-title":"Mucosal profiles of immune molecules related to T helper and regulatory T cells predict future relapse in patients with quiescent ulcerative colitis","volume":"25","author":"Fukaura","year":"2019","journal-title":"Inflamm Bowel Dis"},{"key":"2025032700481218600_CIT0004","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nm.4307","article-title":"Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease","volume":"23","author":"West","year":"2017","journal-title":"Nat Med"},{"key":"2025032700481218600_CIT0005","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1136\/gutjnl-2018-316845","article-title":"TREM-1, the ideal predictive biomarker for endoscopic healing in anti-TNF-treated Crohn\u2019s disease patients","volume":"68","author":"Verstockt","year":"2019","journal-title":"Gut"},{"key":"2025032700481218600_CIT0006","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1007\/s00535-021-01819-7","article-title":"Mucosal IL23A expression predicts the response to ustekinumab in inflammatory bowel disease","volume":"56","author":"Nishioka","year":"2021","journal-title":"J Gastroenterol"},{"key":"2025032700481218600_CIT0007","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12876-021-01709-5","article-title":"Increased mucosal IL-12 expression is associated with relapse of ulcerative colitis","volume":"21","author":"Uchiyama","year":"2021","journal-title":"BMC Gastroenterol"},{"key":"2025032700481218600_CIT0008","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1111\/jgh.15813","article-title":"Mucosal interleukin-8 expression as a predictor of subsequent relapse in ulcerative colitis patients with Mayo Endoscopic Subscore 0","volume":"37","author":"Uchiyama","year":"2022","journal-title":"J Gastroenterol Hepatol"},{"key":"2025032700481218600_CIT0009","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1053\/j.gastro.2007.09.001","article-title":"Diagnostics of inflammatory bowel disease","volume":"133","author":"Nikolaus","year":"2007","journal-title":"Gastroenterology"},{"key":"2025032700481218600_CIT0010","first-page":"74","article-title":"[second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 3: special situations (Spanish version)]","volume":"80","author":"van Assche","year":"2015","journal-title":"Rev Gastroenterol Mex"},{"key":"2025032700481218600_CIT0011","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1053\/j.gastro.2020.12.031","article-title":"STRIDE-II: an update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) initiative of the International Organization for the Study of IBD (IOIBD): determining therapeutic goals for treat-to-target strategies in IBD","volume":"160","author":"Turner","year":"2021","journal-title":"Gastroenterology"},{"key":"2025032700481218600_CIT0012","doi-asserted-by":"crossref","first-page":"18367","DOI":"10.3748\/wjg.v20.i48.18367","article-title":"Prognosis of ulcerative colitis differs between patients with complete and partial mucosal healing, which can be predicted from the platelet count","volume":"20","author":"Nakarai","year":"2014","journal-title":"World J Gastroenterol"},{"key":"2025032700481218600_CIT0013","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/ecco-jcc\/jjv158","article-title":"Evaluation of the risk of relapse in ulcerative colitis according to the degree of mucosal healing (Mayo 0 vs 1): a longitudinal cohort study","volume":"10","author":"Barreiro-de Acosta","year":"2016","journal-title":"J Crohns Colitis"},{"key":"2025032700481218600_CIT0014","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1093\/ecco-jcc\/jjaa184","article-title":"Risk of relapse in patients with ulcerative colitis with persistent endoscopic healing: a durable treatment endpoint","volume":"15","author":"Jangi","year":"2021","journal-title":"J Crohns Colitis"},{"key":"2025032700481218600_CIT0015","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1136\/gutjnl-2019-320056","article-title":"Automatic, computer-aided determination of endoscopic and histological inflammation in patients with mild to moderate ulcerative colitis based on red density","volume":"69","author":"Bossuyt","year":"2020","journal-title":"Gut"},{"key":"2025032700481218600_CIT0016","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1007\/s00384-015-2332-5","article-title":"Quantification of autofluorescence imaging can accurately and objectively assess the severity of ulcerative colitis","volume":"30","author":"Moriichi","year":"2015","journal-title":"Int J Colorectal Dis"},{"key":"2025032700481218600_CIT0017","doi-asserted-by":"crossref","first-page":"869981","DOI":"10.3389\/fmed.2022.869981","article-title":"Predicting histological healing and recurrence in ulcerative colitis by assessing mucosal vascular pattern under narrow-band imaging endoscopy","volume":"9","author":"He","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"2025032700481218600_CIT0018","doi-asserted-by":"crossref","first-page":"E76","DOI":"10.1055\/s-0042-119393","article-title":"Evaluation of the severity of ulcerative colitis using endoscopic dual red imaging targeting deep vessels","volume":"05","author":"Naganuma","year":"2017","journal-title":"Endosc Int Open"},{"key":"2025032700481218600_CIT0019","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1093\/ecco-jcc\/jjx026","article-title":"Assessment of endoscopic mucosal healing of ulcerative colitis using linked colour imaging, a novel endoscopic enhancement system","volume":"11","author":"Uchiyama","year":"2017","journal-title":"J Crohns Colitis"},{"key":"2025032700481218600_CIT0020","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1111\/jgh.15489","article-title":"The efficacy of linked color imaging for the endoscopic diagnosis of mucosal healing in quiescent ulcerative colitis","volume":"36","author":"Takagi","year":"2021","journal-title":"J Gastroenterol Hepatol"},{"key":"2025032700481218600_CIT0021","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJM198712243172603","article-title":"Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study","volume":"317","author":"Schroeder","year":"1987","journal-title":"N Engl J Med"},{"key":"2025032700481218600_CIT0022","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1136\/gut.47.3.404","article-title":"A reproducible grading scale for histological assessment of inflammation in ulcerative colitis","volume":"47","author":"Geboes","year":"2000","journal-title":"Gut"},{"key":"2025032700481218600_CIT0023","doi-asserted-by":"crossref","first-page":"G1163","DOI":"10.1152\/ajpgi.00292.2011","article-title":"Serpin B1 protects colonic epithelial cell via blockage of neutrophil elastase activity and its expression is enhanced in patients with ulcerative colitis","volume":"302","author":"Uchiyama","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2025032700481218600_CIT0024","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1053\/j.gastro.2005.06.071","article-title":"Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts","volume":"129","author":"Andoh","year":"2005","journal-title":"Gastroenterology"},{"key":"2025032700481218600_CIT0025","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.3748\/wjg.v19.i17.2638","article-title":"Expression of interleukin-22\/STAT3 signaling pathway in ulcerative colitis and related carcinogenesis","volume":"19","author":"Yu","year":"2013","journal-title":"World J Gastroenterol"},{"key":"2025032700481218600_CIT0026","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.3389\/fimmu.2020.02148","article-title":"A double edged sword role of interleukin-22 in wound healing and tissue regeneration","volume":"11","author":"Arshad","year":"2020","journal-title":"Front Immunol"},{"key":"2025032700481218600_CIT0027","first-page":"534","article-title":"Il-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis","volume":"118","author":"Sugimoto","year":"2008","journal-title":"J Clin Invest"},{"key":"2025032700481218600_CIT0028","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1146\/annurev-immunol-032414-112123","article-title":"Interleukin-22: immunobiology and pathology","volume":"33","author":"Dudakov","year":"2015","journal-title":"Annu Rev Immunol"},{"key":"2025032700481218600_CIT0029","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1002\/eji.202048573","article-title":"Musculin is highly enriched in Th17 and IL-22-producing ILC3s and restrains pro-inflammatory cytokines in murine colitis","volume":"51","author":"Yan","year":"2021","journal-title":"Eur J Immunol"},{"key":"2025032700481218600_CIT0030","doi-asserted-by":"crossref","first-page":"18581","DOI":"10.1073\/pnas.1003059107","article-title":"IL-33 is a crucial amplifier of innate rather than acquired immunity","volume":"107","author":"Oboki","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025032700481218600_CIT0031","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1136\/gutjnl-2011-301785","article-title":"Neutralisation of the interleukin-33\/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice","volume":"62","author":"Sedhom","year":"2013","journal-title":"Gut"},{"key":"2025032700481218600_CIT0032","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2183\/pjab.87.463","article-title":"Interleukin-5 and IL-5 receptor in health and diseases","volume":"87","author":"Takatsu","year":"2011","journal-title":"Proc Jpn Acad Ser B Phys Biol Sci"},{"key":"2025032700481218600_CIT0033","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nature13577","article-title":"The alarmin IL-33 promotes regulatory T-cell function in the intestine","volume":"513","author":"Schiering","year":"2014","journal-title":"Nature"},{"key":"2025032700481218600_CIT0034","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3389\/fimmu.2019.00459","article-title":"Combined IL-2 immunocomplex and anti-IL-5 mAb treatment expands Foxp3(+) Treg cells in the absence of eosinophilia and ameliorates experimental colitis","volume":"10","author":"Abo","year":"2019","journal-title":"Front Immunol"},{"key":"2025032700481218600_CIT0035","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nature08636","article-title":"Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells","volume":"463","author":"Moro","year":"2010","journal-title":"Nature"},{"key":"2025032700481218600_CIT0036","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1111\/apt.16147","article-title":"Histologic remission does not offer additional benefit for ulcerative colitis patients in endoscopic remission","volume":"52","author":"Narula","year":"2020","journal-title":"Aliment Pharmacol Ther"},{"key":"2025032700481218600_CIT0037","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.bcp.2015.06.009","article-title":"Biological effects of interleukin-6: clinical applications in autoimmune diseases and cancers","volume":"97","author":"Ho","year":"2015","journal-title":"Biochem Pharmacol"},{"key":"2025032700481218600_CIT0038","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1136\/jclinpath-2014-202493","article-title":"Gene of the month: interleukin 6 (IL-6)","volume":"67","author":"Ataie-Kachoie","year":"2014","journal-title":"J Clin Pathol"},{"key":"2025032700481218600_CIT0039","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1042\/bj2650621","article-title":"Interleukin-6 and the acute phase response","volume":"265","author":"Heinrich","year":"1990","journal-title":"Biochem J"},{"key":"2025032700481218600_CIT0040","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/ni.3153","article-title":"IL-6 as a keystone cytokine in health and disease","volume":"16","author":"Hunter","year":"2015","journal-title":"Nat Immunol"},{"key":"2025032700481218600_CIT0041","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/0016-5085(92)90098-J","article-title":"Evidence for continuous stimulation of interleukin-6 production in Crohn\u2019s disease","volume":"102","author":"Gross","year":"1992","journal-title":"Gastroenterology"},{"key":"2025032700481218600_CIT0042","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/0016-5085(93)90336-B","article-title":"Relationship of functional and antigenic interleukin 6 to disease activity in inflammatory bowel disease","volume":"104","author":"Hyams","year":"1993","journal-title":"Gastroenterology"},{"key":"2025032700481218600_CIT0043","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/75068","article-title":"Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo","volume":"6","author":"Atreya","year":"2000","journal-title":"Nat Med"},{"key":"2025032700481218600_CIT0044","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1172\/JCI21404","article-title":"IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6","volume":"116","author":"Yen","year":"2006","journal-title":"J Clin Invest"},{"key":"2025032700481218600_CIT0045","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.4049\/jimmunol.164.9.4878","article-title":"IL-6 is required for the development of Th1 cell-mediated murine colitis","volume":"164","author":"Yamamoto","year":"2000","journal-title":"J Immunol"},{"key":"2025032700481218600_CIT0046","doi-asserted-by":"crossref","first-page":"E212","DOI":"10.1055\/s-0034-1390707","article-title":"Effect of novel bright image enhanced endoscopy using blue laser imaging (BLI)","volume":"2","author":"Kaneko","year":"2014","journal-title":"Endosc Int Open"},{"key":"2025032700481218600_CIT0047","doi-asserted-by":"crossref","first-page":"44687","DOI":"10.1038\/srep44687","article-title":"HSP70-1 is required for interleukin-5-induced angiogenic responses through eNOS pathway","volume":"7","author":"Park","year":"2017","journal-title":"Sci Rep"},{"key":"2025032700481218600_CIT0048","first-page":"369","article-title":"Neutrophil membrane-camouflaged nanoparticles alleviate inflammation and promote angiogenesis in ischemic myocardial injury","volume":"23","author":"Han","year":"2023","journal-title":"Bioact Mater"},{"key":"2025032700481218600_CIT0049","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1038\/s41416-018-0078-x","article-title":"Differential expression of IL-6\/IL-6R and MAO-A regulates invasion\/angiogenesis in breast cancer","volume":"118","author":"Bharti","year":"2018","journal-title":"Br J Cancer"},{"key":"2025032700481218600_CIT0050","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s10456-019-09688-8","article-title":"Cancer-associated fibroblast-derived WNT2 increases tumor angiogenesis in colon cancer","volume":"23","author":"Unterleuthner","year":"2020","journal-title":"Angiogenesis"}],"container-title":["Journal of Crohn's and Colitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/advance-article-pdf\/doi\/10.1093\/ecco-jcc\/jjae158\/60651402\/jjae158.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/19\/3\/jjae158\/60651402\/jjae158.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/19\/3\/jjae158\/60651402\/jjae158.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T22:55:29Z","timestamp":1743288929000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article\/doi\/10.1093\/ecco-jcc\/jjae158\/7823644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,16]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3,5]]}},"URL":"https:\/\/doi.org\/10.1093\/ecco-jcc\/jjae158","relation":{},"ISSN":["1873-9946","1876-4479"],"issn-type":[{"value":"1873-9946","type":"print"},{"value":"1876-4479","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,3]]},"published":{"date-parts":[[2024,10,16]]},"article-number":"jjae158"}}