{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T18:49:37Z","timestamp":1771267777675,"version":"3.50.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Elderly hospitalized patients with inflammatory bowel disease (IBD) flare and concurrent Clostridioides difficile infection (CDI) are considered at high risk of IBD-related complications. We aimed to evaluate the short-,intermediate-, and long-term post-discharge complications among these patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective multicenter cohort study assessing outcomes of elderly individuals (\u226560 years) hospitalized for an IBD flare who were tested for CDI (either positive or negative) and discharged. The primary outcome was the 3-month post-discharge IBD-related complication rates defined as steroid dependency, re-admissions (emergency department or hospitalization), IBD-related surgery, or mortality. We assessed post-discharge IBD-related complications within 6 month and mortality at 12 month among secondary outcomes. Risk factors for complication were assessed by multivariable logistic regression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In a cohort of 654 patients hospitalized for IBD {age 68.9 (interquartile range [IQR]): 63.9\u201375.2 years, 60.9% ulcerative colitis (UC)}, 23.4% were CDI-positive. Post-discharge complication rates at 3 and 6 months, and 12 months mortality, did not differ significantly between CDI-positive and CDI-negative patients (32% vs 33.1%, p\u2005=\u20050.8; 40.5% vs 42.5%, p\u2005=\u20050.66; and 4.6% vs 8%, p\u2005=\u20050.153, respectively). The Charlson comorbidity index was the only significant risk factor for complications within 3 months (aOR 1.1), whereas mesalamine (5-aminosalicylic acid [5-ASA]) use was protective (aOR 0.6). An UC diagnosis was the sole risk factor for complication at 6 months (aOR 1.5). Clostridioides difficile infection did not significantly impact outcomes or interact with IBD type.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In elderly IBD patients hospitalized for IBD flare and subsequently discharged, a concurrent CDI infection was not associated with post-discharge IBD-related complications or mortality up to 1 year.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjae161","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T11:31:07Z","timestamp":1729596667000},"source":"Crossref","is-referenced-by-count":1,"title":["Post-Discharge Outcomes of Elderly Patients Hospitalized for Inflammatory Bowel Disease Flare Complicated by <i>Clostridioides difficile<\/i> Infection"],"prefix":"10.1093","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2162-2840","authenticated-orcid":false,"given":"Idan","family":"Goren","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Rabin Medical Center, Affiliated with the Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv ,","place":["Israel"]},{"name":"Division of Gastroenterology , SUNY Upstate Medical University, Syracuse, NY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ortal","family":"Fallek Boldes","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine E, Rabin Medical Center, Affiliated with the Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1839-7344","authenticated-orcid":false,"given":"Tomer","family":"Boldes","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Meir Medical Center, Affiliated with the Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleg","family":"Knyazev","sequence":"additional","affiliation":[{"name":"Moscow Clinical Scientific Center named after A. S. Loginov , Moscow ,","place":["Russia"]},{"name":"National Medical Research Center of Coloproctology named after A. N. Ryzhykh , Moscow ,","place":["Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Kagramanova","sequence":"additional","affiliation":[{"name":"Moscow Clinical Scientific Center named after A. S. Loginov , Moscow ,","place":["Russia"]},{"name":"Research Institute of Health Organization and Medical Management , Moscow ,","place":["Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1039-6251","authenticated-orcid":false,"given":"Jimmy K","family":"Limdi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Northern Care Alliance Hospitals NHS Foundation Trust , Manchester ,","place":["UK"]},{"name":"Faculty of Biology, Medicine & Health, University of Manchester , Manchester ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleanor","family":"Liu","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Medicine & Health, University of Manchester , Manchester ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karishma","family":"Sethi-Arora","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Northern Care Alliance Hospitals NHS Foundation Trust , Manchester ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Holvoet","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, VITAZ , St Niklaas ,","place":["Belgium"]},{"name":"Department of Gastroenterology, University Hospital Ghent , Ghent ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Eder","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dietetics and Internal Medicine, Poznan University of Medical Sciences , Poznan ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0076-8549","authenticated-orcid":false,"given":"Cristina","family":"Bezzio","sequence":"additional","affiliation":[{"name":"IBD Center, IRCCS Humanitas Research Hospital , Rozzano, Milan ,","place":["Italy"]},{"name":"Department of Biomedical Sciences, Humanitas University , Pieve Emanuele, Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5677-2534","authenticated-orcid":false,"given":"Simone","family":"Saibeni","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, ASST Rhodense , Rho ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Vernero","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, ASST Rhodense , Rho ,","place":["Italy"]},{"name":"Department of Medical Sciences, University of Turin , Turin ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Alimenti","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, ASST Rhodense , Rho ,","place":["Italy"]},{"name":"Department of Medical Sciences, University of Pavia, Gastroenterology Unit , Pavia ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9275-4242","authenticated-orcid":false,"given":"Mar\u00eda","family":"Chaparro","sequence":"additional","affiliation":[{"name":"Departement of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (JjS-Princesa), Universidad Aut\u00f3noma de Madrid, and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2090-3445","authenticated-orcid":false,"given":"Javier P","family":"Gisbert","sequence":"additional","affiliation":[{"name":"Departement of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (JjS-Princesa), Universidad Aut\u00f3noma de Madrid, and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni","family":"Orfanoudaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital of Heraklion , Heraklion ,","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis E","family":"Koutroubakis","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital of Heraklion , Heraklion ,","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Pugliese","sequence":"additional","affiliation":[{"name":"CEMAD - IBD UNIT - Unit\u00e0 Operativa Complessa di Medicina Interna e Gastroenterologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario \"A. 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