{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:02:04Z","timestamp":1792443724191,"version":"4.5.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T00:00:00Z","timestamp":1730505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and aims<\/jats:title>\n                  <jats:p>Achieving deep remission, encompassing clinical, endoscopic, and biological remission, is the goal in managing Crohn\u2019s disease (CD). The role of histological remission (HR) remains unclear. This study aimed to examine the impact of histological inflammation on clinical relapse risk in CD and explore the relationship between histology, endoscopic scores, and biomarkers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients from the prospective STORI (Stable Remission on Combined Therapy with Immunosuppressors) cohort underwent ileocolonoscopy with Crohn\u2019s Disease Endoscopic Index of Severity calculation and 2 biopsies from the most inflamed or previously inflamed areas. Histological scores (Robarts, Geboes, modified Geboes, Nancy, and IBD-DCA) were determined by 2 independent pathologists in a central reading process. Histological remission was defined by specific score thresholds. Clinical relapse, defined by Crohn\u2019s Disease Activity Index (CDAI)\u2005&amp;gt;\u2005250 or a CDAI increase of 70 points over 2 weeks, was monitored for at least 1 year.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Out of 115 patients included in STORI, 160 biopsies (44 ileal and 116 colonic) from 76 patients were analyzed. Histological remission rates were 46% (Nancy), 55% (Robarts), 61% (Geboes), and 41% (IBD-DCA). During follow-up, 35 patients (46%) experienced a clinical relapse: 37% with HR and 56% without, based on the Nancy score. Among the mucosal healing subgroup (45 patients), 34% with HR, and 44% without relapsed (p\u2005=\u20050.18). Histological scores did not predict clinical relapse. Only fecal calprotectin was a significant predictor in multivariate analysis (p\u2005=\u20050.029).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Despite correlations with endoscopy and biomarkers, histological scores did not predict clinical relapse in CD patients in remission. Thus, these scores are not recommended for clinical practice to assess relapse risk in CD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjae167","type":"journal-article","created":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T11:30:37Z","timestamp":1730547037000},"source":"Crossref","is-referenced-by-count":5,"title":["Impact of Histological Remission for Predicting Clinical Relapse in Crohn\u2019s Disease: A Post Hoc Analysis of the Prospective STORI Cohort"],"prefix":"10.1093","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5490-4350","authenticated-orcid":false,"given":"Catherine","family":"Reenaers","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, CHU Li\u00e8ge-Sart Tilman , Li\u00e8ge ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Enea","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Saint-Antoine , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Nachury","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, CHU Lille , Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Laharie","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, CHU de Bordeaux, Centre Medico-chirurgical Magellan, H\u00f4pital Haut-L\u00e9v\u00eaque, Universit\u00e9 de Bordeaux, INSERM CIC 1401 , Bordeaux ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoram","family":"Bouhnik","sequence":"additional","affiliation":[{"name":"Institut des MICI , Neuilly-sur-Seine ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2337-2902","authenticated-orcid":false,"given":"Mathurin","family":"Fumery","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, CHU Amiens , Amiens ,\u00a0","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Gornet","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital Saint-Louis , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6676-1222","authenticated-orcid":false,"given":"Aur\u00e9lien","family":"Amiot","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kremelin-Bic\u00e8tre , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Altwegg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, CHU Montpellier , Montpellier ,\u00a0","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"de Vos","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, UZ Ghent , Ghent ,\u00a0","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Marteau","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Saint-Antoine , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Bourreille","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, CHU Nantes , Nantes ,\u00a0","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Nancey","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, H\u00f4pital Lyon-Sud, CHU Lyon , Pierre-B\u00e9nite ,","place":["France"]},{"name":"INSERM U1111, CIRI , Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Viennot","sequence":"additional","affiliation":[{"name":"Clinique de l\u2019Alma , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Louis","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, CHU Li\u00e8ge-Sart Tilman , Li\u00e8ge ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Svrcek","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Saint-Antoine , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,11,2]]},"reference":[{"key":"2025041609220274900_CIT0001","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1002\/ibd.21506","article-title":"Development of the Crohn\u2019s disease digestive damage score, the L\u00e9mann score","volume":"17","author":"Pariente","year":"2011","journal-title":"Inflamm Bowel Dis"},{"key":"2025041609220274900_CIT0002","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1136\/gutjnl-2015-310151","article-title":"Validation of the Inflammatory Bowel Disease Disability Index in a population-based cohort","volume":"66","author":"Gower-Rousseau","year":"2017","journal-title":"Gut"},{"key":"2025041609220274900_CIT0003","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1053\/j.gastro.2020.12.031","article-title":"International organization for the study of IBD","volume":"160","author":"Turner","year":"2021","journal-title":"Gastroenterology"},{"key":"2025041609220274900_CIT0004","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1097\/MIB.0000000000000155","article-title":"Assessment of histologic disease activity in Crohn\u2019s disease: a systematic review","volume":"20","author":"Mojtahed","year":"2014","journal-title":"Inflamm Bowel Dis"},{"key":"2025041609220274900_CIT0005","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.cgh.2019.05.002","article-title":"Activity associate with development of colorectal neoplasia","volume":"18","author":"Kirchgesner","year":"2020","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2025041609220274900_CIT0006","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1053\/j.gastro.2011.09.034","article-title":"Maintenance of remission among patients with Crohn\u2019s disease on antimetabolite therapy after infliximab therapy is stopped","volume":"142","author":"Louis","year":"2012","journal-title":"Gastroenterology"},{"key":"2025041609220274900_CIT0007","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/gutjnl-2015-310187","article-title":"Development and validation of the Nancy histological index for UC","volume":"66","author":"Marchal-Bressenot","year":"2017","journal-title":"Gut"},{"key":"2025041609220274900_CIT0008","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1136\/gut.47.3.404","article-title":"A reproducible grading scale for histological assessment of inflammation in ulcerative colitis","volume":"47","author":"Geboes","year":"2000","journal-title":"Gut"},{"key":"2025041609220274900_CIT0009","first-page":"305","article-title":"A simplified geboes score for ulcerative colitis","volume":"11","author":"Jauregui-Amezaga","year":"2017","journal-title":"J Crohns Colitis"},{"key":"2025041609220274900_CIT0010","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1136\/gutjnl-2015-310393","article-title":"Development and validation of a histological index for UC","volume":"66","author":"Mosli","year":"2017","journal-title":"Gut"},{"key":"2025041609220274900_CIT0011","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00428-020-02982-7","article-title":"Maximizing the diagnostic information from biopsies in chronic inflammatory bowel diseases: recommendations from the Erlangen International Consensus Conference on Inflammatory Bowel Diseases and presentation of the IBD-DCA score as a proposal for a new index for histologic activity assessment in ulcerative colitis and Crohn\u2019s disease","volume":"478","author":"Lang-Schwarz","year":"2021","journal-title":"Virchows Arch"},{"key":"2025041609220274900_CIT0012","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/apt.13475","article-title":"Systematic review with meta-analysis: mucosal healing is associated with improved long-term outcomes in Crohn\u2019s disease","volume":"43","author":"Shah","year":"2016","journal-title":"Aliment Pharmacol Ther"},{"key":"2025041609220274900_CIT0013","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/ajg.2015.233","article-title":"Selecting therapeutic targets in inflammatory bowel disease (STRIDE): determining therapeutic goals for treat-to-target","volume":"110","author":"Peyrin-Biroulet","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"2025041609220274900_CIT0014","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1053\/j.gastro.2016.12.004","article-title":"Inflammatory bowel disease 2017: innovations and changing paradigms","volume":"152","author":"Colombel","year":"2017","journal-title":"Gastroenterology"},{"key":"2025041609220274900_CIT0015","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/j.cgh.2017.02.016","article-title":"Histologic normalization occurs in ulcerative colitis and is associated with improved clinical outcomes","volume":"15","author":"Christensen","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2025041609220274900_CIT0016","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.cgh.2020.04.050","article-title":"Ileal or colonic histologic activity is not associated with clinical relapse in patients with Crohn\u2019s disease in endoscopic remission","volume":"19","author":"Hu","year":"2021","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2025041609220274900_CIT0017","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1002\/ibd.21925","article-title":"Majority of patients with inflammatory bowel disease in clinical remission have mucosal inflammation","volume":"18","author":"Baars","year":"2012","journal-title":"Inflamm Bowel Dis"},{"key":"2025041609220274900_CIT0018","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1016\/j.cgh.2020.09.046","article-title":"Treat to Target: the role of histologic healing in inflammatory bowel diseases: a systematic review and meta-analysis","volume":"19","author":"Gupta","year":"2021","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2025041609220274900_CIT0019","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/MCG.0000000000000507","article-title":"Clinical implications of histologic abnormalities in ileocolonic biopsies of patients with Crohn\u2019s disease in remission","volume":"51","author":"Brennan","year":"2017","journal-title":"J Clin Gastroenterol"},{"key":"2025041609220274900_CIT0020","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/apt.16232","article-title":"Transmural healing and MRI healing are associated with lower risk of bowel damage progression than endoscopic mucosal healing in Crohn\u2019s disease","volume":"53","author":"Lafeuille","year":"2021","journal-title":"Aliment Pharmacol Ther"},{"key":"2025041609220274900_CIT0021","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1136\/gutjnl-2023-329964","article-title":"Different levels of healing in inflammatory bowel diseases: mucosal, histological, transmural, barrier and complete healing","volume":"72","author":"Neurath","year":"2023","journal-title":"Gut"},{"key":"2025041609220274900_CIT0022","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1093\/ecco-jcc\/jjaa110","article-title":"LECCO position paper: harmonization of the approach to ulcerative colitis histopathology","volume":"14","author":"Magro","year":"2020","journal-title":"J Crohns Colitis"},{"key":"2025041609220274900_CIT0023","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.crohns.2014.08.011","article-title":"Systematic review: histological remission in inflammatory bowel disease. Is \u2018complete\u2019 remission the new treatment paradigm? An IOIBD initiative","volume":"8","author":"Bryant","year":"2014","journal-title":"J Crohns Colitis"},{"key":"2025041609220274900_CIT0024","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1093\/ecco-jcc\/jjaa010","article-title":"Comparison of the Nancy Index with continuous Geboes Score: histological remission and response in ulcerative colitis","volume":"14","author":"Magro","year":"2020","journal-title":"J Crohns Colitis"},{"key":"2025041609220274900_CIT0025","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1136\/gutjnl-2014-307477","article-title":"Comparing histological activity indexes in UC","volume":"64","author":"Bressenot","year":"2015","journal-title":"Gut"},{"key":"2025041609220274900_CIT0026","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1097\/MIB.0b013e318280e75f","article-title":"Correlation between the endoscopic and histologic score in assessing the activity of ulcerative colitis","volume":"19","author":"Lemmens","year":"2013","journal-title":"Inflamm Bowel Dis"},{"key":"2025041609220274900_CIT0027","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3390\/diagnostics13122112","article-title":"Inflammatory bowel diseases: does one histological score fit all","volume":"13","author":"Villanacci","year":"2023","journal-title":"Diagnostics"},{"key":"2025041609220274900_CIT0028","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1111\/j.1365-2036.2008.03835.x","article-title":"Correlation of faecal calprotectin and lactoferrin with an endoscopic score for Crohn\u2019s disease and histological findings","volume":"28","author":"Sipponen","year":"2008","journal-title":"Aliment Pharmacol Ther"}],"container-title":["Journal of Crohn's and Colitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/advance-article-pdf\/doi\/10.1093\/ecco-jcc\/jjae167\/61182664\/jjae167.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/19\/4\/jjae167\/61182664\/jjae167.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/19\/4\/jjae167\/61182664\/jjae167.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T13:22:25Z","timestamp":1744809745000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article\/doi\/10.1093\/ecco-jcc\/jjae167\/7866754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,2]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4,4]]}},"URL":"https:\/\/doi.org\/10.1093\/ecco-jcc\/jjae167","relation":{},"ISSN":["1873-9946","1876-4479"],"issn-type":[{"value":"1873-9946","type":"print"},{"value":"1876-4479","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,4]]},"published":{"date-parts":[[2024,11,2]]},"article-number":"jjae167"}}