{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:22:42Z","timestamp":1792693362472,"version":"4.5.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Data on upadacitinib therapy in children with ulcerative colitis (UC) or unclassified inflammatory bowel disease (IBD-U) are scarce. We aimed to evaluate the effectiveness and safety of upadacitinib as an induction therapy in pediatric UC or IBD-U.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this multicenter retrospective study, children treated with upadacitinib for induction of remission of active UC or IBD-U from 30 centers worldwide were enrolled. Demographic, clinical, and laboratory data, as well as adverse events (AEs), were recorded at Week 8 post-induction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred children were included (90 UC and 10 IBD-U, median age 15.6 [interquartile range 13.3\u201317.1] years). Ninety-eight were previously treated with biologic therapies, and 76 were treated with \u22652 biologics. At the end of the 8-week induction period, clinical response, clinical remission, and corticosteroid-free clinical remission (CFR) were observed in 84%, 62%, and 56% of the children, respectively. Normal C-reactive protein and fecal calprotectin (FC) &amp;lt;150 mcg\/g were achieved in 75% and 50%, respectively. Combined CFR and FC remission was observed in 18\/46 (39%) children with available data at 8 weeks. Adverse events were recorded in 37 children, including 1 serious AE of an appendiceal neuroendocrine tumor. The most frequent AEs were hyperlipidemia (n\u2005=\u200513), acne (n\u2005=\u200512), and infections (n\u2005=\u200510, 5 of whom with herpes viruses).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Upadacitinib is an effective induction therapy for refractory pediatric UC and IBD-U. Efficacy should be weighed against the potential risks of AEs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjae182","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T23:29:03Z","timestamp":1732663743000},"source":"Crossref","is-referenced-by-count":21,"title":["Upadacitinib for Induction of Remission in Pediatric Ulcerative Colitis: An International Multicenter Study"],"prefix":"10.1093","volume":"19","author":[{"given":"Anat","family":"Yerushalmy-Feler","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology Institute, \u201cDana-Dwek\u201d Children\u2019s Hospital, Tel Aviv Sourasky Medical Center , Tel Aviv ,","place":["Israel"]},{"name":"Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A","family":"Spencer","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Susan and Leonard Feinstein IBD Clinical Center, Icahn School of Medicine at Mount Sinai , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9023-4948","authenticated-orcid":false,"given":"Michael T","family":"Dolinger","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Susan and Leonard Feinstein IBD Clinical Center, Icahn School of Medicine at Mount Sinai , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3524-5150","authenticated-orcid":false,"given":"David L","family":"Suskind","sequence":"additional","affiliation":[{"name":"University of Washington Medical School , Seattle, WA ,","place":["USA"]},{"name":"Seattle Children\u2019s Hospital IBD Center , Seattle, WA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Mitrova","sequence":"additional","affiliation":[{"name":"Second Faculty of Medicine, Charles University and Motol University Hospital Department of Paediatrics, , Prague ,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ondrej","family":"Hradsky","sequence":"additional","affiliation":[{"name":"Second Faculty of Medicine, Charles University and Motol University Hospital Department of Paediatrics, , Prague ,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1ire A","family":"Conrad","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Children\u2019s Hospital of Philadelphia , Philadelphia, PA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0038-318X","authenticated-orcid":false,"given":"Judith R","family":"Kelsen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Children\u2019s Hospital of Philadelphia , Philadelphia, PA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6111-7355","authenticated-orcid":false,"given":"Holm H","family":"Uhlig","sequence":"additional","affiliation":[{"name":"Translational Gastroenterology Unit, University of Oxford , Oxford ,","place":["UK"]},{"name":"Biomedical Research Centre, University of Oxford , Oxford ,","place":["UK"]},{"name":"University of Oxford Department of Paediatrics, , Oxford ,","place":["UK"]},{"name":"Centre of Human Genetics, University of Oxford , Oxford 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