{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:44:18Z","timestamp":1793832258160,"version":"4.6.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The aim of this Delphi study was to reach consensus on a new clinical decision tool to help identify or exclude Crohn\u2019s disease (CD) in patients with perianal fistula(s) (PAF).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A panel of international experts in the field of proctology\/inflammatory bowel disease was invited to participate. In the first round (electronic survey), participants were asked to anonymously provide their opinion probing (1) the relevance and use of clinical characteristics suggestive of underlying CD, (2) the use of fecal calprotectin (FCP) for screening for CD, and (3) on the diagnostic work-up for CD in PAF patients with raised clinical suspicion. In the second\/third round (virtual consensus meetings), statements were paired\/revised and presented in final sets of statements. Consensus was predefined as \u226570% (dis)agreement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Final consensus was reached on 12 statements, including screening of all PAF patients (regardless of the complexity, biological behavior, and co-existent perianal symptoms) and referral of PAF patients for a colonoscopy in case of elevated FCP levels (\u2265150 mcg\/g) and\/or in case of one clinical major criterion (defined as: unintentional weight loss, unexplained diarrhea, PSC, UC, &amp;gt;1 internal fistula openings, fistula involving other organs (vagina\/bladder), recurrent fistulation (after initial healing), proctitis, and anal stenosis). Also, clinical (fistula-)characteristics that warrant raised suspicion for CD and an algorithm on the diagnostic work-\/follow-up of patients with raised suspicion were defined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>International consensus was reached on a new, clinical decision tool, including a practical and relevant algorithm for finding\/excluding CD in PAF patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjaf002","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T11:45:14Z","timestamp":1736250314000},"source":"Crossref","is-referenced-by-count":12,"title":["Diagnosing Crohn\u2019s disease in presumed cryptoglandular perianal fistulas: an expert Delphi consensus on early identification of patients at risk of Crohn\u2019s disease in perianal fistulas (PREFAB)"],"prefix":"10.1093","volume":"19","author":[{"given":"Liesbeth J","family":"Munster","sequence":"first","affiliation":[{"name":"Department of Surgery, Flevoziekenhuis , Almere ,","place":["The Netherlands"]},{"name":"Department of Surgery, Amsterdam UMC, location VUmc , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke N","family":"Hanna","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St. Mark\u2019s Hospital , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailsa L","family":"Hart","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St. Mark\u2019s Hospital , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2532-7267","authenticated-orcid":false,"given":"Phil J","family":"Tozer","sequence":"additional","affiliation":[{"name":"Department of Surgery, St. Mark\u2019s Hospital , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9425-8683","authenticated-orcid":false,"given":"Christianne J","family":"Buskens","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam UMC, location VUmc , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarmila D W","family":"van der Bilt","sequence":"additional","affiliation":[{"name":"Department of Surgery, Flevoziekenhuis , Almere ,","place":["The Netherlands"]},{"name":"Department of Surgery, Amsterdam UMC, location VUmc , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"TOpCLASS perianal Crohn\u2019s disease Consortium, the Dutch Initiative on Crohn and Colitis (ICC) and the Initiative on Crohn and Colitis - Surgery (ICC-S)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Dige","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology, Aarhus University Hospital ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilli","family":"Lundby","sequence":"additional","affiliation":[{"name":"Department of Surgery, Aarhus University Hospital ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christianne J","family":"Buskens","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam UMC, location VUmc, Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap","family":"Stoker","sequence":"additional","affiliation":[{"name":"Department of Radiology, Amsterdam UMC ,","place":["The Netherlands"]},{"name":"University of Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarmila D W","family":"van der Bilt","sequence":"additional","affiliation":[{"name":"Department of Surgery, Flevoziekenhuis , Almere ,","place":["The Netherlands"]},{"name":"Department of Surgery, Amsterdam UMC, location VUmc, Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dermot P B","family":"McGovern","sequence":"additional","affiliation":[{"name":"F. 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