{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:50:00Z","timestamp":1774687800318,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["CA214679"],"award-info":[{"award-number":["CA214679"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Patients with inflammatory bowel disease (IBD) face increased risk of colorectal cancer (CRC). While the natural history of conventional dysplastic precursor lesions has been well-studied, the neoplastic potential of recently described nonconventional (NC) IBD-associated colonic mucosal lesions is unclear. We aimed to assess the incidence of antecedent NC lesions in patients with IBD who developed CRC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A case-cohort study was performed to include patients with a diagnosis of IBD with or without CRC who underwent at least 2 surveillance endoscopic procedures at our institution between 1\/1\/2007 and 5\/31\/2023. NC lesions included serrated change and indefinite for dysplasia. Detection rates pre- and post-introduction of high-definition (HD) surveillance colonoscopy were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 87 patients with IBD and CRC and 200 patients with IBD without CRC were identified. Of the cases, a majority had ulcerative colitis (n\u2005=\u200552, 60%), most commonly with extensive involvement (n\u2005=\u200546, 89%). Conventional (hazard ratio [HR] 2.18, 95% confidence interval [CI] 1.34-3.52) and NC (HR 2.28, 95% CI 1.59-3.26) lesions were associated with increased risk of CRC. Conventional lesions in the post-HD era appeared to have a stronger association with CRC (HR 2.79, 95% CI 1.62-4.77) than NC lesions (HR 1.62, 95% CI 0.86-3.06).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both conventional and NC lesions seem to be associated with increased risk of CRC. Conventional lesions are more strongly associated with CRC than NC lesions in the post-HD era, but misclassifications in the pre-HD era may have resulted in a biased increased risk estimate for NC lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjaf022","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T23:18:45Z","timestamp":1738279125000},"source":"Crossref","is-referenced-by-count":0,"title":["Nonconventional dysplasia in patients with inflammatory bowel disease and colorectal adenocarcinoma: a case-cohort study"],"prefix":"10.1093","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2337-0480","authenticated-orcid":false,"given":"Siri A","family":"Urquhart","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology , Mayo Clinic, Rochester, MN ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namratha","family":"Pallipamu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology , Mayo Clinic, Rochester, MN ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hima Varsha","family":"Voruganti","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology , Mayo Clinic, Rochester, MN ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhavana","family":"Baraskar","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology , Mayo Clinic, Rochester, MN ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratyusha","family":"Muddaloor","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology , Mayo Clinic, Rochester, MN ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arshia K","family":"Sethi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology , Mayo Clinic, Rochester, MN ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renisha","family":"Redij","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology , Mayo Clinic, Rochester, MN ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keirthana","family":"Aedma","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology , Mayo Clinic, Rochester, MN ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keerthy","family":"Gopalakrishnan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology , Mayo Clinic, Rochester, MN ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivaram","family":"Poigai Arunachalam","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology , Mayo Clinic, Rochester, MN ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelli N","family":"Burger","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Division of\u00a0Clinical Trials and Biostatistics, Mayo Clinic , Rochester,\u00a0MN ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas W","family":"Mahoney","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Division of\u00a0Clinical Trials and Biostatistics, Mayo Clinic , Rochester,\u00a0MN ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blake A","family":"Kassmeyer","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Division of\u00a0Clinical Trials and Biostatistics, Mayo Clinic , Rochester,\u00a0MN ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan J","family":"Lennon","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Division of\u00a0Clinical Trials and Biostatistics, Mayo Clinic , Rochester,\u00a0MN ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John B","family":"Kisiel","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology , Mayo Clinic, Rochester, MN ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayantara","family":"Coelho-Prabhu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology , Mayo Clinic, Rochester, MN ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"key":"2026032803574097400_CIT0001","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.cgh.2016.10.039","article-title":"Incidence and prevalence of Crohn\u2019s disease and ulcerative colitis in Olmsted County, Minnesota from 1970 through 2010","volume":"15","author":"Shivashankar","year":"2017","journal-title":"Clin Gastroenterol Hepatol."},{"key":"2026032803574097400_CIT0002","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1053\/j.gastro.2021.10.035","article-title":"Colorectal cancer in inflammatory bowel disease: mechanisms and management","volume":"162","author":"Shah","year":"2022","journal-title":"Gastroenterology."},{"key":"2026032803574097400_CIT0003","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.cgh.2014.07.018","article-title":"Colonoscopy is associated with a reduced risk for colon cancer and mortality in patients with inflammatory bowel diseases","volume":"13","author":"Ananthakrishnan","year":"2015","journal-title":"Clin Gastroenterol Hepatol."},{"key":"2026032803574097400_CIT0004","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.humpath.2023.05.008","article-title":"Colorectal dysplasia in chronic inflammatory bowel disease: a contemporary consensus classification and interobserver study","volume":"138","author":"Harpaz","year":"2023","journal-title":"Hum Pathol."},{"key":"2026032803574097400_CIT0005","doi-asserted-by":"publisher","first-page":"83","DOI":"10.4132\/jptm.2021.02.17","article-title":"Non-conventional dysplastic subtypes in inflammatory bowel disease: a review of their diagnostic characteristics and potential clinical implications","volume":"55","author":"Choi","year":"2021","journal-title":"J Pathol Transl Med."},{"key":"2026032803574097400_CIT0006","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1097\/PAP.0000000000000316","article-title":"The significance of flat\/invisible dysplasia and nonconventional dysplastic subtypes in inflammatory bowel disease: a review of their morphologic, clinicopathologic, and molecular characteristics","volume":"29","author":"Choi","year":"2022","journal-title":"Adv Anat Pathol."},{"key":"2026032803574097400_CIT0007","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.path.2023.05.006","article-title":"Characteristics, reporting, and potential clinical significance of nonconventional dysplasia in inflammatory bowel disease","volume":"16","author":"Choi","year":"2023","journal-title":"Surg Pathol Clin"},{"key":"2026032803574097400_CIT0008","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1097\/MIB.0000000000000795","article-title":"DNA methylation and mutation of small colonic neoplasms in ulcerative colitis and Crohn\u2019s colitis: implications for surveillance","volume":"22","author":"Johnson","year":"2016","journal-title":"Inflamm Bowel Dis."},{"key":"2026032803574097400_CIT0009","doi-asserted-by":"publisher","first-page":"178","DOI":"10.4251\/wjgo.v7.i10.178","article-title":"Fecal DNA testing for colorectal cancer screening: molecular targets and perspectives","volume":"7","author":"Dhaliwal","year":"2015","journal-title":"World J Gastrointest Oncol"},{"key":"2026032803574097400_CIT0010","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1007\/s00428-020-02998-z","article-title":"Interobserver agreement and the impact of mentorship on the diagnosis of inflammatory bowel disease-associated dysplasia among subspecialist gastrointestinal pathologists","volume":"478","author":"Alpert","year":"2021","journal-title":"Virchows Arch."},{"key":"2026032803574097400_CIT0011","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s10151-020-02349-9","article-title":"IG-IBD pathology group. diagnostic interobserver variability in Crohn\u2019s disease- and ulcerative colitis-associated dysplasia: a multicenter digital survey from the IG-IBD Pathologists Group","volume":"25","author":"Leoncini","year":"2021","journal-title":"Tech Coloproctol."},{"key":"2026032803574097400_CIT0012","doi-asserted-by":"publisher","first-page":"8715263","DOI":"10.1155\/2018\/8715263","article-title":"Interobserver agreement in the diagnosis of inflammatory bowel disease-associated neoplasia in China in comparison to subspecialized American gastrointestinal pathologists","volume":"2018","author":"Wu","year":"2018","journal-title":"Gastroenterol Res Pract"},{"key":"2026032803574097400_CIT0013","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1053\/j.gastro.2021.05.063","article-title":"AGA clinical practice update on endoscopic surveillance and management of colorectal dysplasia in inflammatory bowel diseases: expert review","volume":"161","author":"Murthy","year":"2021","journal-title":"Gastroenterology."},{"key":"2026032803574097400_CIT0014","doi-asserted-by":"publisher","first-page":"100419","DOI":"10.1016\/j.modpat.2023.100419","article-title":"Poor diagnostic reproducibility in the identification of nonconventional dysplasia in colitis impacts the application of histologic stratification tools","volume":"37","author":"Nasreddin","year":"2023","journal-title":"Mod Pathol."},{"key":"2026032803574097400_CIT0015","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1038\/s41379-019-0419-1","article-title":"Nonconventional dysplasia in patients with inflammatory bowel disease and colorectal carcinoma: a multicenter clinicopathologic study","volume":"33","author":"Choi","year":"2020","journal-title":"Mod Pathol."},{"key":"2026032803574097400_CIT0016","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1093\/ecco-jcc\/jjab120","article-title":"Hypermucinous, Goblet cell-deficient and crypt cell dysplasias in inflammatory bowel disease are often associated with flat\/invisible endoscopic appearance and advanced neoplasia on follow-up","volume":"16","author":"Choi","year":"2022","journal-title":"J Crohns Colitis."},{"key":"2026032803574097400_CIT0017","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1111\/his.14298","article-title":"Non-conventional dysplasia in inflammatory bowel disease is more frequently associated with advanced neoplasia and aneuploidy than conventional dysplasia","volume":"78","author":"Lee","year":"2021","journal-title":"Histopathology."},{"key":"2026032803574097400_CIT0018","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1016\/s0895-4356(99)00102-x","article-title":"Analysis of case-cohort designs","volume":"52","author":"Barlow","year":"1999","journal-title":"J Clin Epidemiol."},{"key":"2026032803574097400_CIT0019","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1093\/ecco-jcc\/jjac090","article-title":"Increased risk of non-conventional and invisible dysplasias in patients with primary sclerosing cholangitis and inflammatory bowel disease","volume":"16","author":"Zhang","year":"2022","journal-title":"J Crohns Colitis."},{"key":"2026032803574097400_CIT0020","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/s0016-5107(04)01710-9","article-title":"Most dysplasia in ulcerative colitis is visible at colonoscopy","volume":"60","author":"Rutter","year":"2004","journal-title":"Gastrointest Endosc."},{"key":"2026032803574097400_CIT0021","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.gie.2006.09.025","article-title":"Are dysplasia and colorectal cancer endoscopically visible in patients with ulcerative colitis","volume":"65","author":"Rubin","year":"2007","journal-title":"Gastrointest Endosc."},{"key":"2026032803574097400_CIT0022","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1016\/j.gie.2017.09.030","article-title":"Endoscopy in inflammatory bowel disease: advances in dysplasia detection and management","volume":"86","author":"Kaltenbach","year":"2017","journal-title":"Gastrointest Endosc."},{"key":"2026032803574097400_CIT0023","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1080\/00365520701866150","article-title":"Is dysplasia visible during surveillance colonoscopy in patients with ulcerative colitis","volume":"43","author":"Blonski","year":"2008","journal-title":"Scand J Gastroenterol."},{"key":"2026032803574097400_CIT0024","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1053\/j.gastro.2016.08.002","article-title":"Comparison of targeted vs random biopsies for surveillance of ulcerative colitis-associated colorectal cancer","volume":"151","author":"Watanabe","year":"2016","journal-title":"Gastroenterology."},{"key":"2026032803574097400_CIT0025","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.gie.2014.12.009","article-title":"SCENIC international consensus statement on surveillance and management of dysplasia in inflammatory bowel disease","volume":"81","author":"Laine","year":"2015","journal-title":"Gastrointest Endosc."},{"key":"2026032803574097400_CIT0026","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.gie.2021.07.024","article-title":"Beyond the SCENIC route: updates in chromoendoscopy and dysplasia screening in patients with inflammatory bowel disease","volume":"95","author":"Rabinowitz","year":"2022","journal-title":"Gastrointest Endosc."},{"key":"2026032803574097400_CIT0027","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/j.crohns.2013.02.009","article-title":"Random biopsies during surveillance colonoscopy increase dysplasia detection in patients with primary sclerosing cholangitis and ulcerative colitis","volume":"7","author":"Navaneethan","year":"2013","journal-title":"J Crohns Colitis."},{"key":"2026032803574097400_CIT0028","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/j.cgh.2018.01.023","article-title":"High risk of advanced colorectal neoplasia in patients with primary sclerosing cholangitis associated with inflammatory bowel disease","volume":"16","author":"Shah","year":"2018","journal-title":"Clin Gastroenterol Hepatol."},{"key":"2026032803574097400_CIT0029","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1093\/ibd\/izaa205","article-title":"Yield of random biopsies during colonoscopies in inflammatory bowel disease patients undergoing dysplasia surveillance","volume":"27","author":"Hu","year":"2021","journal-title":"Inflamm Bowel Dis."},{"key":"2026032803574097400_CIT0030","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1093\/ibd\/izaa146","article-title":"A 1-year cross-sectional inflammatory bowel disease surveillance colonoscopy cohort comparing high-definition white light endoscopy and chromoendoscopy","volume":"27","author":"Coelho-Prabhu","year":"2021","journal-title":"Inflamm Bowel Dis."}],"container-title":["Journal of Crohn's and Colitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/advance-article-pdf\/doi\/10.1093\/ecco-jcc\/jjaf022\/61745789\/jjaf022.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/19\/2\/jjaf022\/61745789\/jjaf022.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/19\/2\/jjaf022\/61745789\/jjaf022.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:57:47Z","timestamp":1774684667000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article\/doi\/10.1093\/ecco-jcc\/jjaf022\/7997891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2,4]]}},"URL":"https:\/\/doi.org\/10.1093\/ecco-jcc\/jjaf022","relation":{},"ISSN":["1873-9946","1876-4479"],"issn-type":[{"value":"1873-9946","type":"print"},{"value":"1876-4479","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,2]]},"published":{"date-parts":[[2025,2]]},"article-number":"jjaf022"}}