{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T11:25:36Z","timestamp":1793877936372,"version":"4.7.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16K09328"],"award-info":[{"award-number":["JP16K09328"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Kyowa Kirin Co., Ltd."},{"name":"Kyowa Hakko Bio Co., Ltd."},{"name":"Kirin Holdings Co., Ltd."},{"name":"Metagen Therapeutics Inc."},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21ae0121038"],"award-info":[{"award-number":["JP21ae0121038"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>Clinical applications of fecal microbiota transplantation (FMT) for treating ulcerative colitis (UC) have shown promising results. However, whether the beneficial effects of FMT are due to the transfer and colonization of donor-derived species in patients remains unclear. Here, we investigated the factors affecting the efficacy of the administration of triple antibiotics (A-FMT) and the criteria for appropriate donor and patient\u2013donor matching.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Ninety-seven patients with active UC who were enrolled between March 2014 and October 2019 underwent FMT. The clinical features were assessed based on a reduction in Lichtiger\u2019s clinical activity index 4 weeks after A-FMT, with long-term responders (LTR) defined as those with no increase or intensification within 12 months after A-FMT. Microbiome analysis was performed on 147 fecal samples (pre-A-FMT, post-A-FMT, and donor) from 49 patient\u2013donor combinations that were assigned using the one-patient-to-one-donor strategy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 97 patients, 61 achieved a clinical response, and of those, 35 were classified as having clinical remission. The efficacy of A-FMT was affected by UC severity and previous administration of steroids (P\u2005=\u2005.027), immunosuppressants (P\u2005=\u2005.049), and biologics (P\u2005=\u2005.029). Effective donors were rich in taxa such as Bacteroidota, which are lost in UC, and the abundances of \u201cpatient-origin\u201d and \u201cnew-amplicon sequence variant\u201d taxa were significantly lower in Responders compared to Nonresponders (Remission; P\u2005=\u2005.03, LTR; P\u2005=\u2005.05). \u201cDonor-derived\u201d amplicon sequence variant sequences, Oscillospiraceae UCG\u2212002 and Alistipes, were significantly enriched in Responders (P\u2005&amp;lt;\u2005.05). Our results showed that the taxonomic composition of patients and the similarity of Bacteroides and butyric-acid-producing bacteria in the patient\u2013donor microbiota significantly influenced A-FMT efficacy (P\u2005&amp;lt;\u2005.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study provides important insights for developing patient-tailored FMT-based therapies for UC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjaf054","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T11:12:10Z","timestamp":1743419530000},"source":"Crossref","is-referenced-by-count":7,"title":["Patient\u2013donor similarity and donor-derived species contribute to the outcome of fecal microbiota transplantation for ulcerative colitis"],"prefix":"10.1093","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1130-2210","authenticated-orcid":false,"given":"Dai","family":"Ishikawa","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Juntendo University School of Medicine , Tokyo,","place":["Japan"]},{"name":"Department of Regenerative Microbiology, Juntendo University Graduate School of Medicine , Tokyo,","place":["Japan"]},{"name":"Metagen Therapeutics, Inc. , Yamagata,","place":["Japan"]},{"name":"Juntendo University Graduate School of Medicine Innovative Microbiome Therapy Research Center , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Regenerative Microbiology, Juntendo University Graduate School of Medicine , Tokyo,","place":["Japan"]},{"name":"Metagen Therapeutics, Inc. , Yamagata,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Juntendo University School of Medicine , Tokyo,","place":["Japan"]},{"name":"Juntendo University Graduate School of Medicine Innovative Microbiome Therapy Research Center , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4255-3274","authenticated-orcid":false,"given":"Xiaochen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Juntendo University School of Medicine , Tokyo,","place":["Japan"]},{"name":"Department of Regenerative Microbiology, Juntendo University Graduate School of Medicine , Tokyo,","place":["Japan"]},{"name":"Juntendo University Graduate School of Medicine Innovative Microbiome Therapy Research Center , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6680-6046","authenticated-orcid":false,"given":"Takafumi","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Juntendo University School of Medicine , Tokyo,","place":["Japan"]},{"name":"Juntendo University Graduate School of Medicine Innovative Microbiome Therapy Research Center , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Odakura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Juntendo University School of Medicine , Tokyo,","place":["Japan"]},{"name":"Juntendo University Graduate School of Medicine Innovative Microbiome Therapy Research Center , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Koma","sequence":"additional","affiliation":[{"name":"Department of 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