{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:42:31Z","timestamp":1783539751755,"version":"3.55.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":63,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italy\u2019s Ministry of Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and aims<\/jats:title>\n                  <jats:p>Inflammatory bowel disease (IBD) patients with Clostridioides difficile infection (CDI) are at increased risk of adverse outcomes. Data on fidaxomicin use in IBD remain scarce. We assessed the effectiveness and safety of fidaxomicin for CDI and its impact on IBD outcomes in a large international cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Adult patients with ulcerative colitis (UC) or Crohn\u2019s disease (CD) treated with fidaxomicin for documented CDI were retrospectively included. The primary outcome was CDI recurrence rate within 8 weeks (C. difficile toxin detection and CDI-targeted therapy). Secondary outcomes included sustained response (no CDI-targeted therapy within 12 weeks), IBD therapy escalation, colectomy rate, and all-cause mortality within 30, 90, and 180 days.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Ninety-six patients (57 UC and 39 CD) from 20 IBD centers were included. Most were on advanced IBD therapy. Half had a previous CDI episode, 15% a severe episode. CDI recurrence rate was 10% at week 8, and sustained response 82% at week 12. Compared with patients with previous CDI episode, patients at first episode tended to have a lower recurrence (4.3% vs 16%; P\u2005=\u2005.06) and higher sustained response (91% vs 75%; P\u2005=\u2005.04) rate. IBD therapy escalation was required in 48% with a numerically lower need for patients achieving vs not-achieving sustained response within 30 days (12% vs 20%; P\u2005=\u2005.42). Five UC patients underwent colectomy. One death unrelated to CDI or IBD occurred. One moderate and 5 mild adverse events were reported.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Fidaxomicin was effective and safe in IBD patients with CDI, with greater effectiveness in CDI-na\u00efve patients, potentially influencing short-term IBD outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjaf056","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T06:56:20Z","timestamp":1743404180000},"source":"Crossref","is-referenced-by-count":3,"title":["Fidaxomicin for <i>Clostridioides difficile<\/i> infection in patients with inflammatory bowel disease: a multicenter retrospective cohort study"],"prefix":"10.1093","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3482-0109","authenticated-orcid":false,"given":"Daniele","family":"Noviello","sequence":"first","affiliation":[{"name":"Department of Pathophysiology and Transplantation, University of Milan , Milano ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9275-4242","authenticated-orcid":false,"given":"Mar\u00eda","family":"Chaparro","sequence":"additional","affiliation":[{"name":"Gastrointestinal Unit of Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-Princesa), Universidad Aut\u00f3noma de Madrid (UAM), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3401-1421","authenticated-orcid":false,"given":"Chiara","family":"Vigan\u00f2","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milano-Bicocca , Monza, Italy"},{"name":"European Reference Network on Hepatological Diseases ERN RARE-LIVER, Fondazione IRCCS San Gerardo dei Tintori , Monza ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9338-4140","authenticated-orcid":false,"given":"Andreas","family":"Blesl","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz , 8036 Graz ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigida","family":"Barberio","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Surgery Oncology and Gastroenterology DiSCOG, University of Padova , Padova ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5483-5271","authenticated-orcid":false,"given":"Henit","family":"Yanai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Rabin Medical Center , Petah Tikva ,","place":["Israel"]},{"name":"Faculty of Medicine, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambrogio","family":"Orlando","sequence":"additional","affiliation":[{"name":"Inflammatory bowel disease Unit, \u201cVilla Sofia-Cervello\u201d Hospital , Palermo ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0469-4332","authenticated-orcid":false,"given":"Roc\u00edo","family":"Ferreiro-Iglesias","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela , A Coru\u00f1a ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0076-8549","authenticated-orcid":false,"given":"Cristina","family":"Bezzio","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University , Pieve Emanuele (MI ),","place":["Italy"]},{"name":"IBD Center, Department of Gastroenterology, IRCCS Humanitas Research Hospital , Rozzano (MI) ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7483-3310","authenticated-orcid":false,"given":"Alessandra","family":"Zilli","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology & Endoscopy, IRCCS San Raffaele Hospital , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4913-7599","authenticated-orcid":false,"given":"Tam\u00e1s","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Szeged , Szeged ,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Gheorghe","sequence":"additional","affiliation":[{"name":"Center of Gastroenterology and Hepatology, Fundeni Clinical Institute , 022328 Bucharest ,","place":["Romania"]},{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy , 050474 Bucharest ,","place":["Romania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Conforti","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2154-0490","authenticated-orcid":false,"given":"Tommaso","family":"Innocenti","sequence":"additional","affiliation":[{"name":"Gastroenterology Research Unit, Department of Experimental and Clinical Biochemical Sciences \u201cMario Serio,\u201d University of Florence , Florence ,","place":["Italy"]},{"name":"IBD Referral Center, Clinical Gastroenterology Unit, Careggi University Hospital , Florence ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5677-2534","authenticated-orcid":false,"given":"Simone","family":"Saibeni","sequence":"additional","affiliation":[{"name":"IBD Centre, Gastroenterology Unit, Rho Hospital, ASST Rhodense , 20017 Rho ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4027-7365","authenticated-orcid":false,"given":"Peter","family":"Bossuyt","sequence":"additional","affiliation":[{"name":"Imelda GI Clinical Research Center, Imelda General Hospital , Bonheiden ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3818-981X","authenticated-orcid":false,"given":"Raquel","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Unidade Local de Sa\u00fade do Algarve, Portim\u00e3o ,","place":["Portugal"]},{"name":"School of Medicine, Life and Health Sciences Research Institute (ICVS), University of Minho , Braga ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Carvalhas Gabrielli","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, ASST Fatebenefratelli-Sacco, 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Gemelli IRCCS , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Pirola","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milano-Bicocca , Monza, Italy"},{"name":"European Reference Network on Hepatological Diseases ERN RARE-LIVER, Fondazione IRCCS San Gerardo dei Tintori , Monza ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Calderone","sequence":"additional","affiliation":[{"name":"Inflammatory bowel disease Unit, \u201cVilla Sofia-Cervello\u201d Hospital , Palermo ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Kornowski Cohen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Rabin Medical Center , Petah Tikva ,","place":["Israel"]},{"name":"Faculty of Medicine, Tel Aviv 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Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1558-8604","authenticated-orcid":false,"given":"Maurizio","family":"Vecchi","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, University of Milan , Milano ,","place":["Italy"]},{"name":"Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8556-8433","authenticated-orcid":false,"given":"Raja","family":"Atreya","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, Universit\u00e4tsklinikum Erlangen and Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , Erlangen 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Gastroenterol Hepatol."},{"key":"2025092417012324400_CIT0027","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1093\/ibd\/izy291","article-title":"Colon surgery risk with corticosteroids versus immunomodulators or biologics in inflammatory bowel disease patients with Clostridium difficile infection","volume":"25","author":"Solanky","year":"2019","journal-title":"Inflamm Bowel Dis."},{"key":"2025092417012324400_CIT0028","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/ibd\/izy308","article-title":"Escalation of immunosuppressive therapy for inflammatory bowel disease is not associated with adverse outcomes after infection with Clostridium difficile","volume":"25","author":"Lukin","year":"2019","journal-title":"Inflamm Bowel Dis."},{"key":"2025092417012324400_CIT0029","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cgh.2009.05.031","article-title":"Combination immunomodulator and antibiotic treatment in patients with inflammatory bowel disease 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